Recovery of hippocampal functions and modulation of muscarinic response by electroacupuncture in young diabetic rats [PDF]
, 2017 The muscarinic receptor response to acetylcholine regulates the hippocampal-related learning, memory, neural plasticity and the production and processing of the pro-nerve growth factor (proNGF) by hippocampal cells.
Berretta, Erica +9 more
core +2 more sources
Functional interaction between p75NTR and TrkA: the endocytic trafficking of p75NTR is driven by TrkA and regulates TrkA-mediated signalling [PDF]
Biochemical Journal, 2004 The topology and trafficking of receptors play a key role in their signalling capability. Indeed, receptor function is related to the microenvironment inside the cell, where specific signalling molecules are compartmentalized. The response to NGF (nerve growth factor) is strongly dependent on the trafficking of its receptor, TrkA.
Perrone L. +5 more
openaire +4 more sources
PLoS ONE, 2012 BackgroundAlthough p75 neurotrophin receptor (p75NTR) is the first neurotrophin receptor isolated, its diverse physiological functions and signaling have remained elusive for many years. Loss-of-function phenotypic analyses for p75NTR were mainly focused
Congcong Zhang +8 more
doaj +1 more source
Frontiers in Immunology, 2022 We have recently provided new evidence for a role of p75NTR receptor and its preferential ligand proNGF in amplifying inflammatory responses in synovial mononuclear cells of chronic arthritis patients.
Luciapia Farina +18 more
doaj +1 more source
Neurotrophin receptor p75NTR mediates Huntington's disease-associated synaptic and memory dysfunction [PDF]
, 2017 Learning and memory deficits are early clinical manifestations of Huntington's disease (HD). These cognitive impairments have been mainly associated with frontostriatal HD pathology; however, compelling evidence provided by several HD murine models ...
Alberch i Vié, Jordi +11 more
core +1 more source
p75 Neurotrophin Receptor Regulates Energy Balance in Obesity
Cell Reports, 2016 Obesity and metabolic syndrome reflect the dysregulation of molecular pathways that control energy homeostasis. Here, we show that the p75 neurotrophin receptor (p75NTR) controls energy expenditure in obese mice on a high-fat diet (HFD).
Bernat Baeza-Raja +16 more
doaj +1 more source
NGF and P75NTR gene expression is associated with the hepatic fibrosis stage due to viral and non-viral causes. [PDF]
PLoS ONE, 2015 This study evaluated the relative mRNA expression levels of nerve growth factor (NGF) and the p75 neurothrophin receptor (p75NTR) in different histological stages of human liver disease.
Ednelza da Silva Graça Amoras +10 more
doaj +1 more source
Neurotrophins Role in Depression Neurobiology: A Review of Basic and Clinical Evidence [PDF]
, 2011 Depression is a neuropsychiatric disorder affecting a huge percentage of the active population especially in developed countries. Research has devoted much of its attention to this problematic and many drugs have been developed and are currently ...
Berrocoso Domínguez, Esther María +4 more
core +4 more sources
NGF Modulates trkANGFR/p75NTR in αSMA-Expressing Conjunctival Fibroblasts from Human Ocular Cicatricial Pemphigoid (OCP). [PDF]
PLoS ONE, 2015 In a previous study, we reported the upregulation of Nerve Growth Factor (NGF) and trkANGFR expression in Ocular Cicatricial Pemphigoid (OCP), an inflammatory and remodeling eye disease.
Alessandra Micera +7 more
doaj +1 more source
Differentiation of Human Embryonic Stem Cells into Cells with Corneal Keratocyte Phenotype [PDF]
, 2013 Corneal transparency depends on a unique extracellular matrix secreted by stromal keratocytes, mesenchymal cells of neural crest lineage. Derivation of keratocytes from human embryonic stem (hES) cells could elucidate the keratocyte developmental pathway
Chan, AA +8 more
core +2 more sources