Results 51 to 60 of about 10,177 (244)

Valproic acid upregulates the expression of the p75NTR/sortilin receptor complex to induce neuronal apoptosis

Apoptosis, 2020
The antiepileptic and mood stabilizer agent valproic acid (VPA) has been shown to exert anti-tumour effects and to cause neuronal damage in the developing brain through mechanisms not completely understood.
S. Dedoni, L. Marras, M. Olianas, A. Ingianni, P. Onali   +4 more
semanticscholar   +1 more source

NGF Modulates trkANGFR/p75NTR in αSMA-Expressing Conjunctival Fibroblasts from Human Ocular Cicatricial Pemphigoid (OCP). [PDF]

PLoS ONE, 2015
In a previous study, we reported the upregulation of Nerve Growth Factor (NGF) and trkANGFR expression in Ocular Cicatricial Pemphigoid (OCP), an inflammatory and remodeling eye disease.
Alessandra Micera, Barbara Stampachiacchiere, Antonio Di Zazzo, Roberto Sgrulletta, Magdalena Cortes, Eduardo Maria Normando, Alessandro Lambiase, Stefano Bonini   +7 more
doaj   +1 more source

Detection of p75NTR Trimers: Implications for Receptor Stoichiometry and Activation [PDF]

Journal of Neuroscience, 2015
The p75 neurotrophin receptor (p75(NTR)) is a multifunctional receptor that participates in many critical processes in the nervous system, ranging from apoptosis to synaptic plasticity and morphological events. It is a member of the tumor necrosis factor receptor (TNFR) superfamily, whose members undergo trimeric oligomerization. Interestingly, p75(NTR)
Anastasia Gonzalez, Agustin, Barker, Phillip A., Chao, Moses V., Hempstead, Barbara L.   +3 more
openaire   +3 more sources

Analysis of p75NTR in medulloblastoma

, 2010
61.
Küchler, J, Hartmann, W, Tronnier, V, Pietsch, T   +3 more
openaire   +2 more sources

Revising the mechanism of p75NTR activation: intrinsically monomeric state of death domains invokes the "helper" hypothesis

Scientific Reports, 2020
The neurotrophin receptor p75NTR plays crucial roles in neuron development and regulates important neuronal processes like degeneration, apoptosis and cell survival. At the same time the detailed mechanism of signal transduction is unclear.
S. Goncharuk, L. E. Artemieva, K. Nadezhdin, A. Arseniev, K. Mineev   +4 more
semanticscholar   +1 more source

Suppression of p75 neurotrophin receptor surface expression with intrabodies influences Bcl-xL mRNA expression and neurite outgrowth in PC12 cells.

PLoS ONE, 2012
BackgroundAlthough p75 neurotrophin receptor (p75NTR) is the first neurotrophin receptor isolated, its diverse physiological functions and signaling have remained elusive for many years. Loss-of-function phenotypic analyses for p75NTR were mainly focused
Congcong Zhang, Saskia Helmsing, Marta Zagrebelsky, Thomas Schirrmann, Andrea L J Marschall, Manuela Schüngel, Martin Korte, Michael Hust, Stefan Dübel   +8 more
doaj   +1 more source

The p75 neurotrophin receptor localization in blood-CSF barrier: expression in choroid plexus epithelium

BMC Neuroscience, 2011
Background The presence of neurotrophins and their receptors Trk family has been reported in the choroid plexus. High levels of Nerve Growth Factor (NGF), Neurotrophin-4 (NT-4) and TrkB receptor were detected, while nothing was know about p75 ...
Spuch Carlos, Carro Eva
doaj   +1 more source

Proneurotrophins Induce Apoptotic Neuronal Death After Controlled Cortical Impact Injury in Adult Mice

ASN Neuro, 2020
The p75 neurotrophin receptor (p75NTR) can regulate multiple cellular functions including proliferation, survival, and apoptotic cell death. The p75NTR is widely expressed in the developing brain and is downregulated as the nervous system matures, with ...
Laura E. Montroull, Deborah E. Rothbard, Hur D. Kanal, Veera D’Mello, Vincent Dodson, Carol M. Troy, Juan P. Zanin, Steven W. Levison, Wilma J. Friedman   +8 more
doaj   +1 more source

Differences in the surface binding and endocytosis of neurotrophins by p75NTR

Molecular and Cellular Neuroscience, 2004
Neurotrophins transmit signals retrogradely from synapses to cell bodies by two different types of surface receptors, p75NTR and Trks. Compared to TrkA, the function of p75NTR in nerve growth factor (NGF) endocytosis is less clear, and it is unknown whether p75NTR by itself may internalize other neurotrophins besides NGF.
Minjie Hu, Jose Miguel Cosgaya, Alex Krüttgen, Alex Krüttgen, Smita Saxena, Charles L. Howe, Joachim Weis, Joachim Weis   +7 more
openaire   +4 more sources

Inactive variants of death receptor p75NTR reduce Alzheimer’s neuropathology by interfering with APP internalization

bioRxiv, 2020
A prevalent model of Alzheimer’s disease (AD) pathogenesis postulates the generation of neurotoxic fragments derived from the amyloid precursor protein (APP) after its internalization to endocytic compartments.
Chenju Yi, Ket Yin Goh, Lik-Wei Wong, Ajeena Ramanujan, Kazuhiro Tanaka, Sreedharan Sajikumar, C. Ibáñez   +6 more
semanticscholar   +1 more source