Results 81 to 90 of about 10,177 (244)

Role of Serum Brain‐Derived Neurotrophic Factor as a Biomarker of Chronic Pain in Older Adults

European Journal of Pain, Volume 29, Issue 5, May 2025.
ABSTRACT Background Serum brain‐derived neurotrophic factor (BDNF) has emerged as a promising biomarker for chronic pain (CP) research and treatment. Yet, most human studies have been limited by small sample sizes, inadequate control of confounders and a lack of focus on sex and mental health differences.
R. Ortolá, M. Sotos‐Prieto, A. Carballo, S. Cabello‐Plan, Aida Koni, V. Mustieles, L. M. García‐Segura, A. R. Artalejo, F. Rodríguez‐Artalejo, E. García‐Esquinas   +9 more
wiley   +1 more source

Contribution of Schwann Cells to Remyelination in a Naturally Occurring Canine Model of CNS Neuroinflammation. [PDF]

PLoS ONE, 2015
Gliogenesis under pathophysiological conditions is of particular clinical relevance since it may provide evidence for regeneration promoting cells recruitable for therapeutic purposes.
Kristel Kegler, Ingo Spitzbarth, Ilka Imbschweiler, Konstantin Wewetzer, Wolfgang Baumgärtner, Frauke Seehusen   +5 more
doaj   +1 more source

A p75NTR Pivoting Paradigm Propels Perspicacity [PDF]

Neuron, 2009
The p75 neurotrophin receptor (p75(NTR)) is involved in numerous neuronal signaling paths but its fundamental signaling mechanisms are unknown. In this issue of Neuron, Vilar et al. show that p75NTR functions as a covalently crosslinked dimer to transduce NGF-induced signaling events.
openaire   +3 more sources

Mimicking the Dystrophic Cardiac Extracellular Environment through DystroGel

Advanced Healthcare Materials, Volume 14, Issue 9, April 4, 2025.
This research introduces DystroGel, a cutting‐edge biocompatible pathological hydrogel derived from decellularized dystrophic porcine heart tissue, suitable for tissue modeling applications. Rheological and proteomic analyses reveal structural and protein composition modifications, underscoring its unique properties.
Maila Chirivì, Fabio Maiullari, Marika Milan, Maria Grazia Ceraolo, Nicole Fratini, Alessandra Fasciani, Salma Bousselmi, Michael Stirm, Francesca Scalera, Francesca Gervaso, Michela Villa, Raffaello Viganò, Francesca Brambilla, Pierluigi Mauri, Elena De Falco, Dario Di Silvestre, Marco Costantini, Eckhard Wolf, Claudia Bearzi, Roberto Rizzi   +19 more
wiley   +1 more source

Umbilical artery tissue contains p75 neurotrophin receptor-positive pericyte-like cells that possess neurosphere formation capacity and neurogenic differentiation potential

Regenerative Therapy, 2021
Introduction: The p75 neurotrophin receptor (p75NTR) is known as an efficient marker for the prospective isolation of mesenchymal stem cells (MSCs) and neural crest-derived stem cells (NCSCs). To date, there is quite limited information concerning p75NTR-
Rina Fujii-Tezuka, Mika Ishige-Wada, Narihito Nagoshi, Hideyuki Okano, Hideo Mugishima, Shori Takahashi, Ichiro Morioka, Taro Matsumoto   +7 more
doaj  

Sexual Dimorphism in Balance and Coordination in p75NTRexonIII Knock-Out Mice

Frontiers in Behavioral Neuroscience, 2022
The p75 neurotrophin receptor (p75NTR) is implicated in various biological functions during development and adulthood. Several animal models have been developed to identify the roles of p75NTR in vivo and in vitro. P75NTRExonIII knock-out mice are widely
Mahdi Abbasian, Annick Langlois, Julien Gibon   +2 more
doaj   +1 more source

Nogo receptor antagonizes p75NTR-dependent motor neuron death [PDF]

Proceedings of the National Academy of Sciences, 2008
The Nogo-66 receptor (NgR) plays a critical role in restricting axon regeneration in the central nervous system. This inhibitory action is in part mediated by a neuronal receptor complex containing p75NTR, a multifunctional receptor also well known to trigger cell death upon binding to neurotrophins such as NGF.
Dupuis, L, Pehar, M, Cassina, P, Rene, F, Castellanos, R, Rouaux, C, Gandelman, M, Dimou, L, Schwab, M E, Loeffler, J P, Barbeito, L, Gonzalez de Aguilar, J L   +11 more
openaire   +4 more sources

Escherichia coli in the production of biopharmaceuticals

Biotechnology and Applied Biochemistry, Volume 72, Issue 2, Page 528-541, April 2025.
Abstract Escherichia coli has shouldered a massive workload with the discovery of recombinant DNA technology. A new era began in the biopharmaceutical industry with the production of insulin, the first recombinant protein, in E. coli and its use in treating diabetes. After insulin, many biopharmaceuticals produced from E. coli have been approved by the
İbrahim İncir, Özlem Kaplan
wiley   +1 more source

Biochanin A Reduces Drug-Induced p75NTR Expression and Enhances Cell Survival: A NewIn VitroAssay for Screening Inhibitors of p75NTR Expression [PDF]

Rejuvenation Research, 2010
Following spinal cord injury (SCI) or peripheral neuropathy, increased levels of the p75(NTR) death receptor initiate the signal transduction cascade leading to cell death. Investigations of compounds that may ameliorate neuronal cell death have largely used rodent models, which are time consuming, expensive, and cumbersome to perform. Previous studies
Fraser Henderson, Daniel Djakiew, Lara H. El Touny   +2 more
openaire   +3 more sources

Ligand Fingerprinting in the Membrane Dynamics of Single TrkA and P75NTR Neurotrophin Receptors [PDF]

Biophysical Journal, 2015
We have sought to investigate the responses of Nerve Growth Factor (NGF) receptors TrkA and P75NTR at the plasma membrane of living neuronal cells by single-molecule imaging and tracking. To this purpose we exploit the acyl carrier peptide and some of its shortened versions (A1 and S6 tags, labeled selectively by two different PPTases) to tag human ...
LUIN, Stefano, MARCHETTI, LAURA, BONSIGNORE, FULVIO, BELTRAM, Fabio, CATTANEO, ANTONINO   +4 more
openaire   +5 more sources