Results 1 to 10 of about 24,664,088 (323)

Targeting PAI-1 in Cardiovascular Disease: Structural Insights Into PAI-1 Functionality and Inhibition [PDF]

Frontiers in Cardiovascular Medicine, 2020
Plasminogen activator inhibitor-1 (PAI-1), a member of the serine protease inhibitor (serpin) superfamily with antiprotease activity, is the main physiological inhibitor of tissue-type (tPA) and urokinase-type (uPA) plasminogen activators (PAs).
Machteld Sillen, Paul J. Declerck
doaj   +4 more sources

PAI‐1 in tissue fibrosis [PDF]

Journal of Cellular Physiology, 2012
AbstractFibrosis is defined as a fibroproliferative or abnormal fibroblast activation‐related disease. Deregulation of wound healing leads to hyperactivation of fibroblasts and excessive accumulation of extracellular matrix (ECM) proteins in the wound area, the pathological manifestation of fibrosis.
A. Ghosh, D. Vaughan
semanticscholar   +3 more sources

PAI-1 augments mucosal damage in colitis [PDF]

Science Translational Medicine, 2019
SERPINE1/PAI-1 is elevated in the colon tissue of the most difficult-to-treat patients with IBD and leads to worsening of experimental colitis. A punch to the gut by PAI-1 Only a fraction of patients with inflammatory bowel disease (IBD) respond to ...
G. Kaiko, Feidi Chen, Chin-Wen Lai, I-Ling Chiang, J. Perrigoue, A. Stojmirović, Katherine Li, B. Muegge, U. Jain, K. VanDussen, Bridie J. Goggins, S. Keely, J. Weaver, P. Foster, D. Lawrence, Ta-Chiang Liu, T. Stappenbeck   +16 more
semanticscholar   +3 more sources

Reversing PAI-1 deficiency in blood using mRNA lipid nanoparticles [PDF]

Molecular Therapy: Methods & Clinical Development
Plasminogen activator inhibitor-1 (PAI-1) deficiency is a rare disorder that causes moderate to severe bleeding and cardiac fibrosis, caused by mutation in the SERPINE-1 gene and no detectable circulating PAI-1 protein.
Francesca Ferraresso, Chad W. Skaer, Katherine Badior, Serena M. Pulente, Manoj Paul, Laura Ketelboeter, Taylor H.S. Chen, Pieter R. Cullis, Sweta Gupta, Amy Shapiro, Erin E. Mulvihill, Christian J. Kastrup   +11 more
doaj   +2 more sources

PAI-1 Exacerbates White Adipose Tissue Dysfunction and Metabolic Dysregulation in High Fat Diet-Induced Obesity

Frontiers in Pharmacology, 2018
Background: Plasminogen activator inhibitor (PAI)-1 levels and activity are known to increase during metabolic syndrome and obesity. In addition, previous studies have implicated PAI-1 in adipose tissue (AT) expansion while also contributing to insulin ...
Lin Wang, Lin Wang, Liyuan Chen, Liyuan Chen, Zheran Liu, Yaofang Liu, Mao Luo, Mao Luo, Ni Chen, Ni Chen, Xin Deng, Xin Deng, Yulin Luo, Yulin Luo, Jing He, Jing He, Liping Zhang, Liping Zhang, Michael A. Hill, Michael A. Hill, Michael A. Hill, Michael A. Hill, Rong Li, Rong Li, Jianbo Wu, Jianbo Wu, Jianbo Wu   +26 more
doaj   +2 more sources

PAI-1-dependent endothelial cell death determines severity of radiation-induced intestinal injury. [PDF]

PLoS ONE, 2012
Normal tissue toxicity still remains a dose-limiting factor in clinical radiation therapy. Recently, plasminogen activator inhibitor type 1 (SERPINE1/PAI-1) was reported as an essential mediator of late radiation-induced intestinal injury. However, it is
Rym Abderrahmani, Agnes François, Valerie Buard, Georges Tarlet, Karl Blirando, Mohammad Hneino, Aurelie Vaurijoux, Marc Benderitter, Jean-Christophe Sabourin, Fabien Milliat   +9 more
doaj   +2 more sources

Overview: PAI-1 inhibitors and clinical applications. [PDF]

Biomed J
Plasminogen activator inhibitor-1 (PAI-1) is a protein involved in the fibrinolytic system and has been reported to be involved in various pathologies such as fibrosis and inflammation. We have developed small molecule inhibitors of human PAI-1 for clinical applications.
Miyata T.
europepmc   +3 more sources

PAI-1 [PDF]

Springer Reference Medizin, 2019

semanticscholar   +2 more sources

Unconventional localization of PAI-1 in PML bodies: A possible link with cellular growth of endothelial cells [PDF]

Biochemistry and Biophysics Reports
Plasminogen activator inhibitor-1 (PAI-1/Serpin E1) is classically known for its antifibrinolytic activity via inhibiting uPA and tPA of the fibrinolytic pathway.
Pragya Gehlot, Daniela Brünnert, Vibha Kaushik, Arpana Yadav, Saloni Bage, Kritika Gaur, Mahesh Saini, Jens Ehrhardt, Gowrang Kasaba Manjunath, Abhishek Kumar, Neena Kasliwal, Ajay Kumar Sharma, Marek Zygmunt, Pankaj Goyal   +13 more
doaj   +2 more sources

Influence of high intensity interval training on adipose tissue PAI-2 and MMP-2 mRNAs expression in rat with high-fat diet-induced metabolic syndrome [PDF]

Journal of Exercise & Organ Cross Talk, 2022
The aim of this study was to investigate the influence of high intensity interval training on adipose tissue PAI-2 and MMP-2 mRNAs expression in rat with high-fat diet-induced metabolic syndrome.
Mojgan Banihashemi, Ensiyeh Yazdkhasti, Maryam Mahmoudi Haghshenas, Fatemeh Rostamkhani   +3 more
doaj   +1 more source