Results 1 to 10 of about 67,837 (164)

Targeting PAI-1 in Cardiovascular Disease: Structural Insights Into PAI-1 Functionality and Inhibition [PDF]

Frontiers in Cardiovascular Medicine, 2020
Plasminogen activator inhibitor-1 (PAI-1), a member of the serine protease inhibitor (serpin) superfamily with antiprotease activity, is the main physiological inhibitor of tissue-type (tPA) and urokinase-type (uPA) plasminogen activators (PAs).
Machteld Sillen, Paul J Declerck
exaly   +5 more sources

Reversing PAI-1 deficiency in blood using mRNA lipid nanoparticles [PDF]

Molecular Therapy: Methods & Clinical Development
Plasminogen activator inhibitor-1 (PAI-1) deficiency is a rare disorder that causes moderate to severe bleeding and cardiac fibrosis, caused by mutation in the SERPINE-1 gene and no detectable circulating PAI-1 protein.
Francesca Ferraresso, Chad W. Skaer, Katherine Badior, Serena M. Pulente, Manoj Paul, Laura Ketelboeter, Taylor H.S. Chen, Pieter R. Cullis, Sweta Gupta, Amy Shapiro, Erin E. Mulvihill, Christian J. Kastrup   +11 more
doaj   +2 more sources

Overview: PAI-1 inhibitors and clinical applications. [PDF]

Biomed J
Plasminogen activator inhibitor-1 (PAI-1) is a protein involved in the fibrinolytic system and has been reported to be involved in various pathologies such as fibrosis and inflammation. We have developed small molecule inhibitors of human PAI-1 for clinical applications.
Miyata T.
europepmc   +3 more sources

Influence of high intensity interval training on adipose tissue PAI-2 and MMP-2 mRNAs expression in rat with high-fat diet-induced metabolic syndrome [PDF]

Journal of Exercise & Organ Cross Talk, 2022
The aim of this study was to investigate the influence of high intensity interval training on adipose tissue PAI-2 and MMP-2 mRNAs expression in rat with high-fat diet-induced metabolic syndrome.
Mojgan Banihashemi, Ensiyeh Yazdkhasti, Maryam Mahmoudi Haghshenas, Fatemeh Rostamkhani   +3 more
doaj   +1 more source

Unconventional localization of PAI-1 in PML bodies: A possible link with cellular growth of endothelial cells [PDF]

Biochemistry and Biophysics Reports
Plasminogen activator inhibitor-1 (PAI-1/Serpin E1) is classically known for its antifibrinolytic activity via inhibiting uPA and tPA of the fibrinolytic pathway.
Pragya Gehlot, Daniela Brünnert, Vibha Kaushik, Arpana Yadav, Saloni Bage, Kritika Gaur, Mahesh Saini, Jens Ehrhardt, Gowrang Kasaba Manjunath, Abhishek Kumar, Neena Kasliwal, Ajay Kumar Sharma, Marek Zygmunt, Pankaj Goyal   +13 more
doaj   +2 more sources

Upaya Meningkatkan Hasil Belajar Siswa Kelas VIII A SMP Negeri 1 Buntulia Pada Mata Pelajaran Pendidikan Agama Islam Melalui Penerapan Model Pembelajaran Kooperatif tipe Think Talk Write

Aksara, 2021
Penelitian ini merupakan Penelitian Tindakan Kelas (PTK) dengan mencoba menerapan salah satu model pembelajaran untuk mengaktifkansiswa dan mengefektifkan proses pembelajaran yaitu pembelajaran kooperatif tipe Think Talk Write.
Warni Diange
doaj   +1 more source

PAI-1 and kidney fibrosis [PDF]

Frontiers in Bioscience, 2009
Substantial evidence demonstrates a link of increased plasminogen activator inhibitor-1 (PAI-1) and glomerulosclerosis and kidney fibrosis, providing a novel therapeutic option for prevention and treatment of chronic kidney diseases. Several mechanisms contributing to increased PAI-1 will be addressed, including classic key profibrotic factors such as ...
Li-Jun, Ma, Agnes B, Fogo
openaire   +2 more sources

PAI‐1 in tissue fibrosis [PDF]

Journal of Cellular Physiology, 2011
AbstractFibrosis is defined as a fibroproliferative or abnormal fibroblast activation‐related disease. Deregulation of wound healing leads to hyperactivation of fibroblasts and excessive accumulation of extracellular matrix (ECM) proteins in the wound area, the pathological manifestation of fibrosis.
Asish K, Ghosh, Douglas E, Vaughan
openaire   +2 more sources

Plasminogen activator inhibitor-1 is involved in impaired bone repair associated with diabetes in female mice. [PDF]

PLoS ONE, 2014
Previous studies suggest that fracture healing is impaired in diabetes; however, the underlying mechanism remains unclear. Here, we investigated the roles of plasminogen activator inhibitor-1 (PAI-1) in the impaired bone repair process by using ...
Li Mao, Naoyuki Kawao, Yukinori Tamura, Katsumi Okumoto, Kiyotaka Okada, Masato Yano, Osamu Matsuo, Hiroshi Kaji   +7 more
doaj   +1 more source

PAI-1 inhibits neutrophil efferocytosis [PDF]

Proceedings of the National Academy of Sciences, 2008
Phagocytosis of apoptotic cells, also called efferocytosis, is an essential feature of immune responses and critical for the resolution of inflammation. Plasma and tissue levels of plasminogen activator inhibitor-1 (PAI-1), an inhibitor of fibrinolysis, are elevated in inflammatory conditions, including sepsis and acute lung injury,
Young-Jun, Park, Gang, Liu, Emmanuel F, Lorne, Xia, Zhao, Jing, Wang, Yuko, Tsuruta, Jaroslaw, Zmijewski, Edward, Abraham   +7 more
openaire   +2 more sources