Results 21 to 30 of about 24,664,088 (323)

Plasminogen activator inhibitor-1 is involved in impaired bone repair associated with diabetes in female mice. [PDF]

PLoS ONE, 2014
Previous studies suggest that fracture healing is impaired in diabetes; however, the underlying mechanism remains unclear. Here, we investigated the roles of plasminogen activator inhibitor-1 (PAI-1) in the impaired bone repair process by using ...
Li Mao, Naoyuki Kawao, Yukinori Tamura, Katsumi Okumoto, Kiyotaka Okada, Masato Yano, Osamu Matsuo, Hiroshi Kaji   +7 more
doaj   +1 more source

Plasminogen Activating Inhibitor-1 Might Predict the Efficacy of Anti-PD1 Antibody in Advanced Melanoma Patients

Frontiers in Oncology, 2021
Plasminogen activating inhibitor-1 (PAI-1) plays crucial roles in the development of various cancers, including melanomas. Indeed, various pro-tumorigenic functions of PAI-1 in cancer progression and metastasis have been widely reported.
Kentaro Ohuchi, Yumi Kambayashi, Takanori Hidaka, Taku Fujimura   +3 more
doaj   +1 more source

PAI-1 inhibits neutrophil efferocytosis [PDF]

Proceedings of the National Academy of Sciences, 2008
Phagocytosis of apoptotic cells, also called efferocytosis, is an essential feature of immune responses and critical for the resolution of inflammation. Plasma and tissue levels of plasminogen activator inhibitor-1 (PAI-1), an inhibitor of fibrinolysis, are elevated in inflammatory conditions, including sepsis and acute lung injury,
Young-Jun, Park, Gang, Liu, Emmanuel F, Lorne, Xia, Zhao, Jing, Wang, Yuko, Tsuruta, Jaroslaw, Zmijewski, Edward, Abraham   +7 more
openaire   +2 more sources

Abrogation of plasminogen activator inhibitor-1-vitronectin interaction ameliorates acute kidney injury in murine endotoxemia. [PDF]

PLoS ONE, 2015
Sepsis-induced acute kidney injury (AKI) contributes to the high mortality and morbidity in patients. Although the pathogenesis of AKI during sepsis is poorly understood, it is well accepted that plasminogen activator inhibitor-1 (PAI-1) and vitronectin (
Kamlesh K Gupta, Deborah L Donahue, Mayra J Sandoval-Cooper, Francis J Castellino, Victoria A Ploplis   +4 more
doaj   +1 more source

Plasminogen activator inhibitor-1 (PAI-1) 4G/5G promoter polymorphisms and risk of venous thromboembolism - a meta-analysis and systematic review.

VASA. Zeitschrift fur Gefasskrankheiten, 2020
Background: A 4G/5G polymorphism in the promoter region of the plasminogen activator inhibitor type 1 (PAI-1) gene has been reported to enhance the plasma levels of PAI-1, which plays an important role in fibrinolysis disorders and venous thromboembolism,
Qiang Zhang, Yunrui Jin, Xia Li, Xingqiao Peng, Na Peng, Jifang Song, Mingfang Xu   +6 more
semanticscholar   +1 more source

Plasminogen activator inhibitor-2 (PAI-2) overexpression supports bladder cancer development in PAI-1 knockout mice in N-butyl-N- (4-hydroxybutyl)-nitrosamine- induced bladder cancer mouse model

Journal of Translational Medicine, 2020
Background Accumulating evidence suggests that plasminogen activator inhibitor-1 (PAI-1) plays an important role in bladder tumorigenesis by regulating cell cycle.
Hideki Furuya, Kazukuni Hayashi, Yoshiko Shimizu, Nari Kim, Yutaro Tsukikawa, Runpu Chen, Yijun Sun, Owen T. M. Chan, Ian Pagano, Rafael Peres, Kanani Hokutan, Fumie Igari, Keith S. Chan, Charles J. Rosser   +13 more
doaj   +1 more source

Features of plasminogen activator inhibitor-1 synthesis by local fat depots of different localization in cardiovascular diseases

Российский кардиологический журнал, 2022
Aim. To determine the features of expression and secretion of plasminogen activator inhibitor-1 (PAI-1) by subcutaneous, epicardial and perivascular adipocytes depending on the complexity of coronary artery disease (CAD).Material and methods.
E. V. Belik, O. V. Gruzdeva, Yu. A. Dyleva, E. E. Bychkova, A. A. Kuzmina, S. V. Ivanov, O. L. Barbarash   +6 more
doaj   +1 more source

PAI-1, the Plasminogen System, and Skeletal Muscle

International Journal of Molecular Sciences, 2020
The plasminogen system is a critical proteolytic system responsible for the remodeling of the extracellular matrix (ECM). The master regulator of the plasminogen system, plasminogen activator inhibitor-1 (PAI-1), has been implicated for its role in ...
F. Rahman, M. Krause
semanticscholar   +1 more source

PAI-1 derived from cancer-associated fibroblasts in esophageal squamous cell carcinoma promotes the invasion of cancer cells and the migration of macrophages

Laboratory Investigation, 2020
Cancer-associated fibroblasts (CAFs) contribute to the progression of various cancers. Previously, we reported the significance of CAFs in esophageal squamous cell carcinoma (ESCC); however, the functions of CAFs in the ESCC microenvironment remain ...
H. Sakamoto, Y. Koma, Nobuhide Higashino, T. Kodama, Kohei Tanigawa, Masaki Shimizu, M. Fujikawa, Mari Nishio, Manabu Shigeoka, Y. Kakeji, H. Yokozaki   +10 more
semanticscholar   +1 more source

Inhibition of PAI-1 Activity by Toddalolactone as a Mechanism for Promoting Blood Circulation and Removing Stasis by Chinese Herb Zanthoxylum nitidum var. tomentosum

Frontiers in Pharmacology, 2017
Traditional Chinese medicine has been used to treat a variety of human diseases for many centuries. Zanthoxylum nitidum var. tomentosum is used as an adjuvant to promote blood circulation and remove stasis.
Bo Yu, Guangping Zhang, Lingling Jin, Bo Zhang, Dong Yan, Hong Yang, Zuguang Ye, Tonghui Ma   +7 more
doaj   +1 more source