Results 51 to 60 of about 24,664,088 (323)

Differential Regulation of PAI-1 in Hantavirus Cardiopulmonary Syndrome and Hemorrhagic Fever With Renal Syndrome [PDF]

, 2018
We analyzed the levels of circulating tissue plasminogen activator (tPA) and plasminogen activator inhibitor (PAI)-1 in acute hantavirus cardiopulmonary syndrome (HCPS) and hemorrhagic fever with renal syndrome (HFRS).
Avsic-Zupanc, Tatjana, Bellomo, Carla, Korva, Misa, Martinez, Valeria P., Mustonen, Jukka, Mäkelä, Satu, Papa, Anna, Strandin, Tomas, Vaheri, Antti   +8 more
core   +2 more sources

Inhibition of Plasminogen Activator Inhibitor 1 Attenuates Hepatic Steatosis but Does Not Prevent Progressive Nonalcoholic Steatohepatitis in Mice

Hepatology Communications, 2018
Plasminogen activator inhibitor 1 (PAI‐1), an essential regulator of fibrinolysis, is increasingly implicated in the pathogenesis of metabolic disorders, such as obesity and nonalcoholic fatty liver disease (NAFLD).
Anne S. Henkel, Sadiya S. Khan, Shantel Olivares, Toshio Miyata, Douglas E. Vaughan   +4 more
doaj   +1 more source

The role of the platelet pool of Plasminogen Activator Inhibitor-1 in well-controlled type 2 diabetes patients.

PLoS ONE, 2022
BackgroundThe main inhibitor of the fibrinolytic system, Plasminogen Activator Inhibitor -1 (PAI-1), irreversibly binds tissue-type Plasminogen Activator (t-PA) and thereby inhibits the protective action of tPA against thrombus formation. Elevated levels
Karin Mossberg, Josefin Olausson, Emanuel Fryk, Sverker Jern, Per-Anders Jansson, Helén Brogren   +5 more
doaj   +1 more source

Plasminogen activator inhibitor-1 (PAI-1) 4G/5G polymorphism and endometriosis. Influence of PAI-1 polymorphism on PAI-1 antigen and mRNA expression

Thrombosis Research, 2008
Endometriosis is a benign gynecologic disease with a high prevalence. It is a multifactorial and polygenic entity in which the fibrinolytic system may be implicated. The objective of this study was to evaluate the plasminogen activator inhibitor-1 (PAI-1) 4G/5G polymorphism in a group of women with and without endometriosis and to analyze the influence
Ramírez P, Gilabert-Estelles, Juan, Cosin, Raul, Gilabert, Juan, Espana, Francisco, Castello, Remedios, Chirivella, Melitina, Romeu, Alberto, Estelles, Amparo   +8 more
openaire   +4 more sources

Stress granules counteract senescence by sequestration of PAI‐1

EMBO Reports, 2018
Cellular senescence is a physiological response by which an organism halts the proliferation of potentially harmful and damaged cells. However, the accumulation of senescent cells over time can become deleterious leading to diseases and physiological ...
A. Omer, Devang Patel, X. J. Lian, Jason Sadek, S. Di Marco, A. Pause, M. Gorospe, I. Gallouzi   +7 more
semanticscholar   +1 more source

Aspects of Plasminiogen Activator Inhibitor 1 in Metabolic Syndrome [PDF]

, 2016
Plasminogen activator inhibitor 1 (PAI-1) is the main inhibitor of the fibrinolytic system and binds irreversibly to tissue-type plasminogen activator (t-PA), and thereby inhibits the protective action of t-PA against thrombus formation. Elevated levels
Mossberg, Karin
core   +1 more source

Thrombin Provokes Degranulation of Platelet &agr;-Granules Leading to the Release of Active Plasminogen Activator Inhibitor-1 (PAI-1)

Shock, 2017
Background: The balance of fibrinolytic mediators is crucial to the survival of the critically ill patient, with tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) playing significant roles.
Benjamin R. Huebner, E. Moore, H. Moore, Gregory R Stettler, Geoffrey R. Nunns, P. Lawson, A. Sauaia, M. Kelher, A. Banerjee, C. Silliman   +9 more
semanticscholar   +1 more source

Effects of adenotonsillectomy on plasma inflammatory biomarkers in obese children with obstructive sleep apnea: A community-based study. [PDF]

, 2015
BackgroundObesity and obstructive sleep apnea syndrome (OSA) are highly prevalent and frequently overlapping conditions in children that lead to systemic inflammation, the latter being implicated in the various end-organ morbidities associated with these
Alonso-Álvarez, ML, Bhattacharjee, R, Duran-Cantolla, J, Gileles-Hillel, A, Gozal, D, Kheirandish-Gozal, L, Peris, E, Terán-Santos, J   +7 more
core   +1 more source

Plasminogen Activator Inhibitor-1 Regulates LPS Induced Inflammation in Rat Macrophages through Autophagy Activation

The Scientific World Journal, 2014
Background. The mechanisms by which plasminogen activator inhibitor-1 (PAI-1) regulates inflammation, especially in acute respiratory distress syndrome (ARDS), are largely unknown. Objective.
Zhong-Hui Wang, Wei-Ying Ren, Lei Zhu, Li-Juan Hu   +3 more
doaj   +1 more source

Possible effect of genetic background in thrombophilia genes on clinical severity of patients with coronavirus disease-2019: A prospective cohort study

Baghdad Journal of Biochemistry and Applied Biological Sciences, 2022
Background and objective: Thrombotic and microangiopathic effects have been reported in Coronavirus Disease-2019 (COVID-19) patients. In the present study, we aimed to examine the relationship between hereditary thrombophilia factors and the clinical ...
Ozlem Sezer, Ozgur Gunal, Recai Aci, Adem Keskin   +3 more
doaj   +1 more source