Results 51 to 60 of about 107,265 (203)
FFNT25 ameliorates unilateral ureteral obstruction-induced renal fibrosis
Renal Failure, 2019 Renal fibrosis is a common pathological feature of chronic kidney disease (CKD) patients who progress to end-stage renal disease (ESRD). With the increasing incidence of CKD, it is of importance to develop effective therapies that blunt development of ...
Wen Li +8 more
doaj +1 more source
Effect of Pioglitazone on the Fructose-Induced Abdominal Adipose Tissue Dysfunction [PDF]
, 2012 Aim. To test the potential role of PPARγ in the endocrine abdominal tissue dysfunction induced by feeding normal rats with a fructose rich diet (FRD) during three weeks. Methodology. Adult normal male rats received a standard commercial diet (CD) or FRD,
Alzamendi, Ana +5 more
core +4 more sources
Cells, 2023 Aortic stenosis (AS) is associated with hypofibrinolysis, but its mechanism is poorly understood. We investigated whether LDL cholesterol affects plasminogen activator inhibitor 1 (PAI-1) expression, which may contribute to hypofibrinolysis in AS ...
Magdalena Kopytek +4 more
doaj +1 more source
PAI-1 and Cellular Migration [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2002 “Do not dabble in paradox, it puts you in danger of fortuitous wit.”— T. Stoppard, Arcadia, 1995 The migration of vascular smooth muscle cells (SMCs) plays an important role in the response to vascular injury and in atherosclerosis. In fact, the focal accumulation of smooth muscle in the arterial intima is thought to make a critical contribution to ...
openaire +1 more source
Polymorphisms of plasminogen activator inhibitor-1, angiotensin converting enzyme and coagulation factor XIII genes in patients with recurrent spontaneous abortion [PDF]
, 2011 We investigated polymorphisms of plasminogen activator inhibitor-1 (PAI-1), angiotensin converting enzyme (ACE ) and coagulation factor XIII (FXIII) genes and their association with recurrent spontaneous abortion (RSA) in Iranian patients and normal ...
Aarabi, M. +6 more
core
Hypertension in Pregnancy, 2019 Objective: Investigating D-Dimer/D-Di and plasminogen activator inhibitor type-1/PAI-1 levels throughout gestation in women with preeclampsia/PE risk factors. Methods: D-Di and PAI-1 plasma levels were determined in 28 women at 12–19, 20–29, 30–34 and 35–
Flávia Campos Lucena +9 more
doaj +1 more source
PLoS ONE, 2013 IntroductionPlasminogen activator inhibitor 1 (PAI-1) is a key factor in trauma- and sepsis-induced coagulopathy. We examined how trauma-hemorrhage (TH) modulates PAI-1 responses in subsequent cecal ligation and puncture (CLP)-induced sepsis, and the ...
Pierre Raeven +7 more
doaj +1 more source
PLoS ONE, 2022 BackgroundThe main inhibitor of the fibrinolytic system, Plasminogen Activator Inhibitor -1 (PAI-1), irreversibly binds tissue-type Plasminogen Activator (t-PA) and thereby inhibits the protective action of tPA against thrombus formation. Elevated levels
Karin Mossberg +5 more
doaj +1 more source
The relationship between obesity and plasminogen activator inhibitor 1 type plasma levels in patients with severe traumatic brain injury [PDF]
, 2016 Plasminogen activator inhibitor 1 type (PAI-1) is the principal inhibitor of fibrinolysis. The production of PAI-1 by adipose tissue could be an important contributor to the elevated PAI-1 plasma levels.
Towenna, C.A.
core
Unique secretory dynamics of tissue plasminogen activator and its modulation by plasminogen activator inhibitor-1 in vascular endothelial cells [PDF]
, 2009 We analyzed the secretory dynamics of tissue plasminogen activator (tPA) in EA.hy926 cells, an established vascular endothelial cell (VEC) line producing GFP-tagged tPA, using total internal reflection fluorescence (TIR-F) microscopy.
2722 +7 more
core +2 more sources