Results 31 to 40 of about 34,702 (278)

Protein Palmitoylation Modification During Viral Infection and Detection Methods of Palmitoylated Proteins

Frontiers in Cellular and Infection Microbiology, 2022
Protein palmitoylation—a lipid modification in which one or more cysteine thiols on a substrate protein are modified to form a thioester with a palmitoyl group—is a significant post-translational biological process. This process regulates the trafficking,
Xiaoling Li, Lingyi Shen, Zhao Xu, Wei Liu, Aihua Li, Jun Xu   +5 more
doaj   +1 more source

Posttranslational modifications of GLUT4 affect its subcellular localization and translocation [PDF]

, 2013
The facilitative glucose transporter type 4 (GLUT4) is expressed in adipose and muscle and plays a vital role in whole body glucose homeostasis. In the absence of insulin, only ~1% of cellular GLUT4 is present at the plasma membrane, with the vast ...
Bayer, Begum, Birnbaum, Bogan, Bogan, Bogan, Bryant, Cassie Welburn, Chang, Fujita, Garvey, Gill, Giorgino, Govers, Grasbon-Frodl, Gwyn Gould, Haga, Hardy, Herrmann, Hicke, Huang, Ing, James, James, Jessica Sadler, Jeyaraj, Karylowski, Kupriyanova, Lamb, Lau, Lawrence, Lawrence, Leto, Li, Liu, Livingstone, Mahajan, Marsh, Marshall, Marshall, Martin, Matunis, McCormick, Muller, Nia Bryant, Perera, Pessin, Pilch, Piper, Ren, Reusch, Saltiel, Semiz, Shi, Shi, Stöckli, Toh, Urbe, Vannucci, Varki, Watson, Williams, Yang, Yu, Zaarour   +64 more
core   +3 more sources

Membrane-associated proteins in giardia lamblia [PDF]

, 2018
The manner in which membrane-associated proteins interact with the membrane defines their subcellular fate and function. This interaction relies on the characteristics of the proteins, their journey after synthesis, and their interaction with other ...
Feliziani, Constanza, Ropolo, Andrea Silvana, Touz, Maria Carolina   +2 more
core   +1 more source

Novel components of the Toxoplasma inner membrane complex revealed by BioID. [PDF]

, 2015
UNLABELLED:The inner membrane complex (IMC) of Toxoplasma gondii is a peripheral membrane system that is composed of flattened alveolar sacs that underlie the plasma membrane, coupled to a supporting cytoskeletal network. The IMC plays important roles in
Bell, Hannah N, Bentolila, Laurent A, Bradley, Peter J, Chen, Allan L, Huang, Amy S, Kim, Elliot W, Moon, Andy S, Rashoff, Andrew Q, Toh, Justin Y, Van, Christina, Vashisht, Ajay A, Wohlschlegel, James A   +11 more
core   +3 more sources

ER-Mitochondria contact sites : a new regulator of cellular calcium flux comes into play [PDF]

, 2016
Endoplasmic reticulum (ER)-mitochondria membrane contacts are hotspots for calcium signaling. In this issue, Raturi et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201512077) show that the thioredoxin TMX1 inhibits the calcium pump SERCA2b at ...
Anelli, Appenzeller-Herzog, Bittremieux, Booth, Csordás, Cárdenas, Cárdenas, Doghman-Bouguerra, Geert Bultynck, Hayashi, Higo, Krols, Li, Lynes, Lynes, Marchi, Marino, Michiel Krols, Raturi, Rizzuto, Roderick, Sophie Janssens, Szabadkai   +22 more
core   +2 more sources

Mechanisms and functional implications of ZDHHC5 in cellular physiology and disease

Journal of Lipid Research
Post-translational lipid modification by palmitoylation is a reversible process crucial for maintaining cellular functionality. The palmitoyl acyltransferase zinc finger Asp-His-His-Cys motif-containing 5 (ZDHHC5) has garnered significant attention due ...
Huicong Liu, Shuo Wen, Chang Xu, Xiaohong Kang, Eryan Kong   +4 more
doaj   +1 more source

Multiple palmitoyl acyltransferases modify DAT palmitoylation (803.5)

The FASEB Journal, 2014
The dopamine transporter (DAT) mediates the reuptake of synaptic dopamine, thus regulating dopaminergic neurotransmission. DAT undergoes palmitoylation in which a saturated 16‐carbon palmitate group is linked to cysteine via a thioester bond. Palmitoylation regulates diverse aspects of neuronal protein trafficking and function, but its role in DAT ...
Danielle Rastedt, James Foster, Roxanne Vaughan   +2 more
openaire   +1 more source

Palmitoylation of solute carriers

Biochemical Pharmacology, 2023
Post-translational modifications are an important mechanism in the regulation of protein expression, function, and degradation. Well-known post-translational modifications are phosphorylation, glycosylation, and ubiquitination. However, lipid modifications, including myristoylation, prenylation, and palmitoylation, are poorly studied.
Cecilia E. Villanueva, Bruno Hagenbuch
openaire   +2 more sources

Protein palmitoylation plays an important role in Trichomonas vaginalis adherence [PDF]

, 2018
The flagellated protozoan parasite Trichomonas vaginalis is the etiologic agent of trichomoniasis, the most common non-viral sexually transmitted infection worldwide.
Corvi, Maria Martha, de Miguel, Natalia, Johnson, Patricia J, Metz, Sebastián Darío, Nievas, Yésica Romina, Vashisht, Ajay A., Wohlschlegel, James A.   +6 more
core   +2 more sources

Differential palmitoylation of the endosomal SNAREs syntaxin 7 and syntaxin 8*[S]

Journal of Lipid Research, 2009
Palmitoylation is a posttranslational modification that regulates protein trafficking and stability. In this study we investigated whether the endosomal soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNARE) proteins syntaxin 7 ...
Yuhong He, Maurine E. Linder
doaj   +1 more source