Results 31 to 40 of about 39,498 (303)

Posttranslational modifications of GLUT4 affect its subcellular localization and translocation [PDF]

, 2013
The facilitative glucose transporter type 4 (GLUT4) is expressed in adipose and muscle and plays a vital role in whole body glucose homeostasis. In the absence of insulin, only ~1% of cellular GLUT4 is present at the plasma membrane, with the vast ...
Bayer, Begum, Birnbaum, Bogan, Bogan, Bogan, Bryant, Cassie Welburn, Chang, Fujita, Garvey, Gill, Giorgino, Govers, Grasbon-Frodl, Gwyn Gould, Haga, Hardy, Herrmann, Hicke, Huang, Ing, James, James, Jessica Sadler, Jeyaraj, Karylowski, Kupriyanova, Lamb, Lau, Lawrence, Lawrence, Leto, Li, Liu, Livingstone, Mahajan, Marsh, Marshall, Marshall, Martin, Matunis, McCormick, Muller, Nia Bryant, Perera, Pessin, Pilch, Piper, Ren, Reusch, Saltiel, Semiz, Shi, Shi, Stöckli, Toh, Urbe, Vannucci, Varki, Watson, Williams, Yang, Yu, Zaarour   +64 more
core   +3 more sources

NLRP3 Cys126 palmitoylation by ZDHHC7 promotes inflammasome activation

bioRxiv, 2023
NACHT-, leucine-rich-repeat- (LRR), and pyrin domain-containing protein 3 (NLRP3) mediates inflammasome activation in response to multiple pathogen and damage-associated molecular patterns in macrophages. Hyperactivation of NLRP3 inflammasome contributes
Tao Yu, Dan Hou, Jiaqi Zhao, Xuan Lu, W. Greentree, Qian Zhao, Min Yang, Don-Gerard Conde, M. Linder, Hening Lin   +9 more
semanticscholar   +1 more source

Palmitoylation-driven PHF2 ubiquitination remodels lipid metabolism through the SREBP1c axis in hepatocellular carcinoma

Nature Communications, 2023
Palmitic acid (PA) is the most common fatty acid in humans and mediates palmitoylation through its conversion into palmitoyl coenzyme A. Although palmitoylation affects many proteins, its pathophysiological functions are only partially understood.
D. Jeong, Jong-Wan Park, K. Kim, Jiyoung Kim, June Huh, Jieun Seo, Ye Lee Kim, J. Cho, Kwang-Woong Lee, Junji Fukuda, Yang-Sook Chun   +10 more
semanticscholar   +1 more source

Membrane-associated proteins in giardia lamblia [PDF]

, 2018
The manner in which membrane-associated proteins interact with the membrane defines their subcellular fate and function. This interaction relies on the characteristics of the proteins, their journey after synthesis, and their interaction with other ...
Feliziani, Constanza, Ropolo, Andrea Silvana, Touz, Maria Carolina   +2 more
core   +1 more source

Quantifying protein densities on cell membranes using super-resolution optical fluctuation imaging [PDF]

, 2017
Surface molecules, distributed in diverse patterns and clusters on cell membranes, influence vital functions of living cells. It is therefore important to understand their molecular surface organisation under different physiological and pathological ...
Benda, Aleš, Brdička, Tomáš, Cebecauer, Marek, Glatzová, Daniela, Kvíčalová, Zuzana, Lasser, Theo, Letschert, Sebastian, Levet, Florian, Lukeš, Tomáš, Sauer, Markus   +9 more
core   +11 more sources

Novel components of the Toxoplasma inner membrane complex revealed by BioID. [PDF]

, 2015
UNLABELLED:The inner membrane complex (IMC) of Toxoplasma gondii is a peripheral membrane system that is composed of flattened alveolar sacs that underlie the plasma membrane, coupled to a supporting cytoskeletal network. The IMC plays important roles in
Bell, Hannah N, Bentolila, Laurent A, Bradley, Peter J, Chen, Allan L, Huang, Amy S, Kim, Elliot W, Moon, Andy S, Rashoff, Andrew Q, Toh, Justin Y, Van, Christina, Vashisht, Ajay A, Wohlschlegel, James A   +11 more
core   +3 more sources

ER-Mitochondria contact sites : a new regulator of cellular calcium flux comes into play [PDF]

, 2016
Endoplasmic reticulum (ER)-mitochondria membrane contacts are hotspots for calcium signaling. In this issue, Raturi et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201512077) show that the thioredoxin TMX1 inhibits the calcium pump SERCA2b at ...
Anelli, Appenzeller-Herzog, Bittremieux, Booth, Csordás, Cárdenas, Cárdenas, Doghman-Bouguerra, Geert Bultynck, Hayashi, Higo, Krols, Li, Lynes, Lynes, Marchi, Marino, Michiel Krols, Raturi, Rizzuto, Roderick, Sophie Janssens, Szabadkai   +22 more
core   +2 more sources

ZDHHC2-Mediated AGK Palmitoylation Activates AKT–mTOR Signaling to Reduce Sunitinib Sensitivity in Renal Cell Carcinoma

Cancer Research, 2023
ZDHHC2 confers sunitinib resistance to clear cell renal cell carcinoma by catalyzing AGK palmitoylation to activate the AKT–mTOR pathway.
Yan Sun, Liang Zhu, Pian Liu, Huan Zhang, Feng Guo, Xin Jin   +5 more
semanticscholar   +1 more source

Determinants of the voltage dependence of G protein modulation within calcium channel β subunits [PDF]

, 2008
CaVβ subunits of voltage-gated calcium channels contain two conserved domains, a src-homology-3 (SH3) domain and a guanylate kinase-like (GK) domain with an intervening HOOK domain. We have shown in a previous study that, although Gβγ-mediated inhibitory
A Hummer, A Meir, A Neely, AC Dolphin, AC Meir A Dolphin, AJ Butcher, Andriy V. Dresviannikov, Annette C. Dolphin, B Li, C Altier, C Canti, C Canti, D Bichet, D Walker, DC Bell, EA Ertel, F Bertaso, F Petegem Van, G Sandoz, GJ Stephens, GJ Stephens, J Barclay, J Leroy, Jerôme Leroy, JM Maltez, Karen M. Page, KM Page, L Berrou, L Birnbaumer, LP Jones, M Pragnell, M Waard De, MR Hanlon, MW Richards, MW Richards, N Qin, N Weiss, NL Brice, RM Cohen, SC Stotz, SX Takahashi, SX Takahashi, WA Catterall, Wendy S. Pratt, Y Opatowsky, YH Chen   +45 more
core   +2 more sources

DHHC9-mediated GLUT1 S-palmitoylation promotes glioblastoma glycolysis and tumorigenesis

Nature Communications, 2021
Glucose transporter GLUT1 is a transmembrane protein responsible for the uptake of glucose into the cells of many tissues through facilitative diffusion. Plasma membrane (PM) localization is essential for glucose uptake by GLUT1.
Zhenxing Zhang, Xin Li, Fan Yang, Chao Chen, Ping-sheng Liu, Yi Ren, Pengkai Sun, Zixiong Wang, Y. You, Y. Zeng, Xinjian Li   +10 more
semanticscholar   +1 more source