Results 71 to 80 of about 39,498 (303)

Rescue of aberrant huntingtin palmitoylation ameliorates mutant huntingtin-induced toxicity

Neurobiology of Disease, 2021
Huntington disease (HD) is a neurodegenerative disorder caused by a CAG expansion in the HTT gene that codes for an elongated polyglutamine tract in the huntingtin (HTT) protein.
Fanny L. Lemarié, Nicholas S. Caron, Shaun S. Sanders, Mandi E. Schmidt, Yen T.N. Nguyen, Seunghyun Ko, Xiaohong Xu, Mahmoud A. Pouladi, Dale D.O. Martin, Michael R. Hayden   +9 more
doaj   +1 more source

CD36 facilitates fatty acid uptake by dynamic palmitoylation-regulated endocytosis

Nature Communications, 2020
Fatty acids (FAs) are essential nutrients, but how they are transported into cells remains unclear. Here, we show that FAs trigger caveolae-dependent CD36 internalization, which in turn delivers FAs into adipocytes.
Jian-Wei Hao, Juan Wang, Huiling Guo, Yin-Yue Zhao, Hui-Hui Sun, Yi-fan Li, Xiao-Ying Lai, Ning Zhao, Xu Wang, Changchuan Xie, Lixin Hong, Xi Huang, Hong-Rui Wang, Chengbin Li, Bin Liang, Shuai Chen, Tong-Jin Zhao   +16 more
semanticscholar   +1 more source

Palmitoylation‐Mediated Ubiquitination of SRPK1 Regulates Ferroptosis in High‐Fat‐Induced Erectile Dysfunction

Advanced Science, EarlyView.
Elevated exogenous palmitic acid promotes the S‐palmitoylation of SRPK1 in endothelial cells, a dynamic process governed by ZDHHC24 and APT1. This post‐translational modification strengthens the interaction between SRPK1 and the E3 ubiquitin ligase MIB1, thereby facilitating the proteasomal degradation of SRPK1.
Xiao‐Hui Tan, Ke‐Fan Li, Yi‐Ming Yuan, Man‐Cheng Xia, Fang‐Zhou Zhao, Hong‐Gang Ying, Zhuo Zhou, Peng‐Chao Gao, Guo‐Qing Xie, Xue‐Song Li, Hui Jiang, Rui‐Li Guan   +11 more
wiley   +1 more source

Single-molecule localization microscopy reveals STING clustering at the trans-Golgi network through palmitoylation-dependent accumulation of cholesterol

Nature Communications
Stimulator of interferon genes (STING) is critical for the type I interferon response to pathogen- or self-derived DNA in the cytosol. STING may function as a scaffold to activate TANK-binding kinase 1 (TBK1), but direct cellular evidence remains lacking.
Haruka Kemmoku, Kanoko Takahashi, Kojiro Mukai, Toshiki Mori, Koichiro M. Hirosawa, Fumika Kiku, Yasunori Uchida, Yoshihiko Kuchitsu, Yu Nishioka, Masaaki Sawa, Takuma Kishimoto, Kazuma Tanaka, Yasunari Yokota, Hiroyuki Arai, Kenichi G. N. Suzuki, T. Taguchi   +15 more
semanticscholar   +1 more source

Lost in traffic: consequences of altered palmitoylation in neurodegeneration

Frontiers in Physiology, 2023
One of the first molecular events in neurodegenerative diseases, regardless of etiology, is protein mislocalization. Protein mislocalization in neurons is often linked to proteostasis deficiencies leading to the build-up of misfolded proteins and/or ...
Firyal Ramzan, F. Abrar, Gyanam Mishra, L. M. Q. Liao, D. D. Martin   +4 more
semanticscholar   +1 more source

Palmitoylation of Hedgehog Proteins [PDF]

, 2012
Hedgehog (Hh) proteins are secreted signaling proteins that contain amide-linked palmitate at the N-terminus and cholesterol at the C-terminus. Palmitoylation of Hh proteins is critical for effective long- and short-range signaling. The palmitoylation reaction occurs during transit of Hh through the secretory pathway, most likely in the lumen of the ER.
John A, Buglino, Marilyn D, Resh
openaire   +2 more sources

Fas palmitoylation by the palmitoyl acyltransferase DHHC7 regulates Fas stability [PDF]

Cell Death & Differentiation, 2014
The death receptor Fas undergoes a variety of post-translational modifications including S-palmitoylation. This protein acylation has been reported essential for an optimal cell death signaling by allowing both a proper Fas localization in cholesterol and sphingolipid-enriched membrane nanodomains, as well as Fas high-molecular weight complexes.
Rossin, A, Durivault, J, Chakhtoura-Feghali, T, Lounnas, N, Gagnoux-Palacios, L, Hueber, A-O   +5 more
openaire   +3 more sources

Advanced Human Immune Cell‐Organoid Co‐Cultures for Functional Testing of Cancer Nanovaccines

Advanced Science, EarlyView.
Pancreatic ductal adenocarcinoma remains difficult to treat. We establish an organoid–immune co‐culture using patient‐derived organoids and matched T‐cells to assess cancer vaccines. A mesothelin‐targeted nanovaccine activates antigen‐specific T‐cells, increases IFN‐γ, and targets MSLN+ organoids.
Nathalia Ferreira, David Agorku, Andre Rosa, Julia Roosz, Lena Christ, Nicole Anderle, Ajinkya Kulkarni, Abir Hussein, Sana S. Sayedipour, Omar F. Luna, Tobias Legler, Philipp Ströbel, Fernando Albericio, Luis Cruz, Phillipp Beckhove, Peter Loskill, Frauke Alves, M. Andrea Markus, Fernanda Ramos‐Gomes   +18 more
wiley   +1 more source

Recent advances in S-palmitoylation and its emerging roles in human diseases

Journal of Hematology & Oncology
S-palmitoylation, one reversible post-translational modification (PTM) involving the binding of palmitate to proteins, influences protein stability, localization and interactions.
Juanjuan Shang, Mei Ding, Xiangxiang Zhou   +2 more
doaj   +1 more source

Palmitoylation of ACE2 at Cys141, Cys344, and Cys498 facilitates its extracellular vesicles localization [PDF]

Jichu yixue yu linchuang
Objective To identify S-palmitoylation sites on angiotensin-converting enzyme 2(ACE2), the cellular receptor for severe acute respiratory syndrome corona virus(SARS-CoV) and SARS-CoV-2, and to investigate the functional relevance of these modifications ...
YANG Jingjing, MA Yan, WANG Yue, SUN Yang, LI Pan, GUO Feng
doaj   +1 more source