Results 81 to 90 of about 39,498 (303)

The role of palmitoylation in signalling, cellular trafficking and plasma membrane localization of protease-activated receptor-2. [PDF]

PLoS ONE, 2011
Protease-activated receptor-2 (PAR2) is a G protein coupled receptor (GPCR) activated by proteolytic cleavage of its amino terminal domain by trypsin-like serine proteases. This irreversible activation mechanism leads to rapid receptor desensitization by
Mark N Adams, Melinda E Christensen, Yaowu He, Nigel J Waterhouse, John D Hooper   +4 more
doaj   +1 more source

Repositioning Lomitapide to block ZDHHC5-dependant palmitoylation on SSTR5 leads to anti-proliferation effect in preclinical pancreatic cancer models

Cell Death Discovery, 2023
Palmitoylation of proteins plays important roles in various physiological processes, such as cell proliferation, inflammation, cell differentiation etc. However, inhibition of protein palmitoylation has led to few new drugs to date.
Yumeng Wang, Shujie Zhang, Huiqin He, Hongyi Luo, Yannan Xia, Yuanyuan Jiang, Jingwei Jiang, Li Sun   +7 more
semanticscholar   +1 more source

Posttranslational Protein Palmitoylation [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2007
Posttranslational modification of proteins is the foundation of intracellular signaling. Without the ability to reversibly modify proteins and lipids, cells would be unable to react to signals received from their environment. Posttranslational modification of proteins usually, but not always, occurs after a protein has arrived at the appropriate ...
Adam D. Munday, José A. López
openaire   +1 more source

Integrin β3 Orchestrates Hepatic Steatosis via a Novel CD36‐Dependent Lipid Uptake Complex

Advanced Science, EarlyView.
In MASH, ITGB3 recruits LYN and drives its ubiquitin‐proteasomal degradation via phosphorylation. This relieves DHHC5 inhibition, enabling ITGB3/DHHC5/CD36 complex assembly to enhance CD36 palmitoylation and fatty acid uptake, thereby exacerbating disease. Targeting ITGB3 blocks this pathogenic axis and ameliorates MASH.
Ying Zhang, Lei Dai, Zhongquan Cui, Ye Zhou, Wenyuan Dong, Hongcheng Jiang, Mengwen Wang, Xiaodan Zhong, Wei Dong, Zhang Yue, Thati Madhusudhan, Hongjie Wang, Xiong Zhong Ruan, Hesong Zeng   +13 more
wiley   +1 more source

Coordinated interplay between palmitoylation, phosphorylation and SUMOylation regulates kainate receptor surface expression [PDF]

, 2023
Busra P. Yucel, Enaam Al Momany, Ashley J. Evans, Richard Seager, Kevin A. Wilkinson, Jeremy M. Henley   +5 more
openalex   +3 more sources

Characterisation and expression of β1-, β2- and β3-adrenergic receptors in the fathead minnow (Pimephales promelas) [PDF]

, 2011
This is the author’s version of a work that was accepted for publication in General and Comparative Endocrinology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control ...
Eccles, PD, Giltrow, E, Hutchinson, TH, Rand-Weaver, M, Sumpter, JP   +4 more
core   +1 more source

Small Molecule Inhibitors of TEAD Auto-palmitoylation Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma

Molecular Cancer Therapeutics, 2021
Mutations in the neurofibromatosis type 2 (NF2) gene that limit or abrogate expression of functional Merlin are common in malignant mesothelioma. Merlin activates the Hippo pathway to suppress nuclear translocation of YAP and TAZ, the major effectors of ...
T. Tang, A. Konradi, Ying Feng, Xiao P. Peng, Mingyue Ma, Jian Li, Fa-Xing Yu, K. Guan, L. Post   +8 more
semanticscholar   +1 more source

The Drosophila protein palmitoylome: Characterizing palmitoyl-thioesterases and DHHC palmitoyl-transferases [PDF]

Fly, 2008
Palmitoylation is the post-translational addition of a palmitate moiety to a cysteine residue through a covalent thioester bond. The addition and removal of this modification is controlled by both palmitoyl acyl-transferases and thioesterases. Using bioinformatic analysis, we identified 22 DHHC family palmitoyl acyl-transferase homologs in the ...
Barbra A, Bannan, Jamie, Van Etten, John A, Kohler, Yui, Tsoi, Nicole M, Hansen, Stacey, Sigmon, Elizabeth, Fowler, Haley, Buff, Tiffany S, Williams, Jeffrey G, Ault, Robert L, Glaser, Christopher A, Korey   +11 more
openaire   +2 more sources

Chaperone‐Mediated Autophagic Degradation of USP9X in Macrophages Exacerbates Postmyocardial Infarction Inflammation and Cardiac Dysfunction

Advanced Science, EarlyView.
This study demonstrates that inflammatory stimuli induce the acetylation‐triggered, chaperone‐mediated autophagic degradation of ubiquitin‐specific peptidase 9 X‐linked (USP9X) in macrophages. USP9X acts as a macrophage “inflammation switch” after myocardial infarction (MI). USP9X loss destabilizes tumor necrosis factor receptor‐associated factor (TRAF)
Biqing Wang, Xiangheng Cai, Mengqi Li, Xue Liu, Junhui Xue, Ye Liu, Ding Ai, Xinyang Hu   +7 more
wiley   +1 more source

Inhibiting S-palmitoylation arrests metastasis by relocating Rap2b from plasma membrane in colorectal cancer

Cell Death and Disease
Rap2b, a proto-oncogene upregulated in colorectal cancer (CRC), undergoes protein S-palmitoylation at specific C-terminus sites (C176/C177). These palmitoylation sites are crucial for Rap2b localization on the plasma membrane (PM), as mutation of C176 or
Jiangli Zhu, Xize Cao, Zhenshuai Chen, Birou Lai, Lingling Xi, Jinghang Zhang, Shaohui Zhu, Shiqian Qi, Yinming Liang, Fei Cao, Binhui Zhou, Yu Song, Sheng Jiang, Tianyu Wang, Xiaohong Kang, Eryan Kong   +15 more
doaj   +1 more source