Results 81 to 90 of about 34,702 (278)

Gi- and Gs-coupled GPCRs show different modes of G-protein binding. [PDF]

, 2018
More than two decades ago, the activation mechanism for the membrane-bound photoreceptor and prototypical G protein-coupled receptor (GPCR) rhodopsin was uncovered.
Altenbach, Christian, Caro, Lydia N, Dror, Ron O, Ernst, Oliver P, Hollingsworth, Scott A, Hubbell, Wayne L, Latorraca, Naomi R, Van Eps, Ned   +7 more
core   +1 more source

Semaglutide normalizes increased cardiomyocyte calcium transients in a rat model of high fat diet‐induced obesity

ESC Heart Failure, Volume 12, Issue 2, Page 1386-1397, April 2025.
Sequeira et al. reveal how the glucagon‐like peptide‐1 receptor agonist (GLP‐1‐RA) semaglutide restores cardiomyocyte function in rats subjected to a high‐fat/high‐fructose diet (HFD). Employing fluorescence‐ and patch‐clamp technology in isolated cardiac myocytes, they demonstrate that semaglutide reverses HFD‐induced activation of L‐type calcium ...
Vasco Sequeira, Julia Theisen, Katharina J. Ermer, Marie Oertel, Anton Xu, David Weissman, Katharina Ecker, Jan Dudek, Martin Fassnacht, Alexander Nickel, Michael Kohlhaas, Christoph Maack, Ulrich Dischinger   +12 more
wiley   +1 more source

Chemoproteomics reveals Toll-like receptor fatty acylation [PDF]

, 2014
Partial funding for Open Access provided by The Ohio State University Open Access Fund.Background: Palmitoylation is a 16-carbon lipid post-translational modification that increases protein hydrophobicity.
A Bafica, AF Roth, AI Su, AI Su, BA Merrick, Balyn W Zaro, BH Zheng, BR Martin, BR Martin, C Aicart-Ramos, C Ivaldi, C Salaun, C Wu, CB Lopez, CB Lopez, CT Tom, D Davda, D Rotin, E Latz, E Lorenz, F Sandor, G Charron, G Charron, GJ Freeman, H Kato, HC Hang, Howard C Hang, J Charollais, J Greaves, J Greaves, J Ren, Jacob S Yount, James L Chen, JC Hach, JL Hernandez, Joanne Turner, Jocelyn C Hach, JP Wilson, JS Yount, JS Yount, JS Yount, JS Yount, JS Yount, JS Yount, JS Yount, JS Yount, KJ Brandt, L Dowal, Larry S Schlesinger, M Fukata, M Muzio, M Scheffner, M Triantafilou, M Yamamoto, MA Imro, Matthew R Pratt, ME Linder, Murugesan VS Rajaram, Nicholas M Chesarino, NT Thuong, O Takeuchi, P Hollsberg, P Mill, R Barbalat, R Kang, R Tsutsumi, RM Steinman, RN Hannoush, S Blaskovic, S Borrello, S Kupzig, SC Henry, T Kawai, T Kawai, TR Hawn, Y Bulut, Y Fukata, Y Li, Y Webb, YY Yang, Z Jiang   +80 more
core   +2 more sources

Exploring the role of palmitoylation in sepsis: mechanistic insights and future perspectives

Molecular Medicine
Background The palmitoylation system is intricate, multidimensional, and plays a crucial role in various inflammatory and immune-related disorders.
Susu Cao, Wenyan Xiao, Sinong Pan, Tianfeng Hua, Min Yang   +4 more
doaj   +1 more source

Palmitoylation in cardiometabolic diseases: From molecular mechanisms to clinical implications

Pharmacological Research
Cardiometabolic diseases (CMDs), encompassing both cardiovascular diseases and metabolic syndromes, are among the leading causes of global morbidity and mortality.
Shenghui Feng, Yue Zhou, Linjuan Guo, Yan Liang, Wengen Zhu   +4 more
doaj   +1 more source

Role of Palmitoylation of Postsynaptic Proteins in Promoting Synaptic Plasticity

Frontiers in Molecular Neuroscience, 2019
Many postsynaptic proteins undergo palmitoylation, the reversible attachment of the fatty acid palmitate to cysteine residues, which influences trafficking, localization, and protein interaction dynamics.
Lucas Matt, Karam Kim, Dhrubajyoti Chowdhury, Johannes W. Hell   +3 more
doaj   +1 more source

Proteome‐Wide Analysis of Palmitoylated Proteins in Macrophages Reveals Novel Insights Into Early Immune Signaling

PROTEOMICS, EarlyView.
ABSTRACT Protein S‐palmitoylation, a reversible lipid modification, plays critical roles in regulating protein function and localization. However, its comprehensive role in the rapid reprogramming of macrophages during early immune responses remains incompletely understood.
Hyojung Kim, Jiraphorn Issara‐Amphorn, Sung Hwan Yoon, Anirban Banerjee, Aleksandra Nita‐Lazar   +4 more
wiley   +1 more source

Cellular interactions in the tumor microenvironment: the role of secretome [PDF]

, 2019
Over the past years, it has become evident that cancer initiation and progression depends on several components of the tumor microenvironment, including inflammatory and immune cells, fibroblasts, endothelial cells, adipocytes, and extracellular matrix ...
Castelo-Branco, Pedro, da Cunha, Bianca Rodrigues, Domingos, Célia, Henrique, Tiago, Polachini, Giovana Mussi, Stefanini, Ana Carolina Buzzo, Tajara, Eloiza Helena   +6 more
core   +1 more source

Pharmacological Inhibition of APT2 by Solasonine Promotes Ferroptosis Through Palmitoylation Modulation in Gallbladder Cancer

Phytotherapy Research, EarlyView.
Schematic illustration of SS‐induced ferroptosis through targeting APT2‐mediated STAT3 palmitoylation in GBC cells. ABSTRACT Gallbladder cancer (GBC), the most prevalent and lethal biliary tract malignancy, lacks effective therapeutic strategies. Solasonine (SS), a bioactive steroidal alkaloid derived from Solanum nigrum L, exhibits antitumor activity ...
Liu‐qing Shi, Jing‐wei Zhao, Jia‐yun Zhu, Cheng Zhao, Zi‐yi Yang, Li‐jia Pan, Ben Ma, Zheng‐yu Chen, Zi‐ying Wang, Chun‐jie Li, Shi‐lei Liu, Jia‐wei Mei, Ping Dong   +12 more
wiley   +1 more source

Evidence for the involvement of lipid rafts localized at the ER-mitochondria associated membranes in autophagosome formation [PDF]

, 2016
Mitochondria-associated membranes (MAMs) are subdomains of the endoplasmic reticulum (ER) that interact with mitochondria. This membrane scrambling between ER and mitochondria appears to play a critical role in the earliest steps of autophagy.
Faggioni, Alberto, Gambardella, Lucrezia, Garofalo, Tina, Malorni, Walter, Manganelli, Valeria, Marconi, Matteo, Matarrese, Paola, Misasi, Roberta, Sorice, Maurizio, Tinari, Antonella   +9 more
core   +2 more sources