Results 191 to 200 of about 7,965 (226)

Mechanism of PAMAM Dendrimers Internalization in Hippocampal Neurons

Molecular Pharmaceutics, 2016
Polyamidoamine (PAMAM) dendrimers are hyperbranched macromolecules which have been described as one of the most promising drug nanocarrier systems. A key process to understand is their cellular internalization mechanism because of its direct influence on their intracellular distribution, association with organelles, entry kinetics, and cargo release ...
Felipe, Vidal, Pilar, Vásquez, Carola, Díaz, Daniela, Nova, Joel, Alderete, Leonardo, Guzmán   +5 more
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DNA Assisted Self-Assembly of PAMAM Dendrimers

The Journal of Physical Chemistry B, 2014
We report DNA assisted self-assembly of polyamidoamine (PAMAM) dendrimers using all atom Molecular Dynamics (MD) simulations and present a molecular level picture of a DNA-linked PAMAM dendrimer nanocluster, which was first experimentally reported by Choi et al. (Nano Lett., 2004, 4, 391-397). We have used single stranded DNA (ssDNA) to direct the self-
Mandal, Taraknath, Kumar, Mattaparthi Venkata Satish, Maiti, Prabal K   +2 more
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PAMAM Dendrimers as Delivery Agents for Antisense Oligonucleotides

Pharmaceutical Research, 1999
To investigate the potential use of PAMAM dendrimers for the delivery of antisense oligonucleotides into cells under conditions that mimic the in vivo environment.We used HeLa cells stably transfected with plasmid pLuc/705 which has a luciferase gene interrupted by a human beta-globin intron mutated at nucleotide 705, thus causing incorrect splicing ...
H, Yoo, P, Sazani, R L, Juliano
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PAMAM Dendrimers for siRNA Delivery: Computational and Experimental Insights

Chemistry – A European Journal, 2010
AbstractShort double‐stranded RNAs, which are known as short interfering RNA (siRNA), can be used to specifically down‐regulate the expression of the targeted gene in a process known as RNA interference (RNAi). However, the success of gene silencing applications based on the use of synthetic siRNA critically depends on efficient intracellular delivery.
Pavan GM, POSOCCO, PAOLA, Tagliabue A., Maly M., Malek A., Danani A., Ragg E., Catapano C. V., PRICL, SABRINA   +8 more
openaire   +5 more sources

Supramolecular mimetic peroxidase based on hemin and PAMAM dendrimers

Chem. Commun., 2008
An acid-base interaction between hemin and PAMAM dendrimers affords supramolecular non-covalent peroxidase systems whose catalytic activity is enhanced after spontaneous electrostatic self-assembling onto a solid surface.
CASTRICIANO MA, ROMEO, Andrea, BARATTO MC, POGNI R, MONSU' SCOLARO, Luigi   +4 more
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Self‐assembled PAMAM dendrimer films

Advanced Materials, 1997
Self‐assembly of starburst dendrimers into closely packed cells (see the optical micrograph in the Figure) is reported for generation 9.5 polyamidoamine (PAMAM) dendrimers solvent‐cast onto hydrophilic silicon substrates. It is shown that on the microscopic scale the cells are made up of a complex network of intertwined dendritic microfibrils ...
Simon A. Evenson, Jas Pal S. Badyal
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Influence of PAMAM dendrimers on the human insulin

AIP Conference Proceedings, 2015
Dendrimers are specific class of polymeric macromolecules with wide spectrum of properties. One of the promising activities of dendrimers involves inhibition of protein fibril formation. Aggregation and fibrillation of insulin occurs in insulin-dependent diabetic patients after repeated administration, due to these processes being very easily triggered
Olga Nowacka, Katarzyna Miłowska, Maksim Ionov, Maria Bryszewska   +3 more
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DNA-Templated Covalent Coupling of G4 PAMAM Dendrimers

Journal of the American Chemical Society, 2010
Generation-4 polyamidoamine (PAMAM) dendrimers were surface-functionalized with azides or alkynes and conjugated to one DNA strand. DNA-controlled self-assembly of alternating azide and alkyne dendrimers on a DNA template enabled the coupling of the dendrimers by the azide-alkyne "click" reaction to form covalently coupled dimers, trimers, and ...
Liu, Huajie, Tørring, Thomas; id_orcid 0000-0001-5257-2121, Dong, Mingdong; id_orcid 0000-0002-2025-2171, Rosen, Christian B, Besenbacher, Flemming, Gothelf, Kurt V   +5 more
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On the Ability of PAMAM Dendrimers and Dendrimer/DNA Aggregates To Penetrate POPC Model Biomembranes

The Journal of Physical Chemistry B, 2010
Poly(amido amine) (PAMAM) dendrimers have previously been shown, as cationic condensing agents of DNA, to have high potential for nonviral gene delivery. This study addresses two key issues for gene delivery: the interaction of the biomembrane with (i) the condensing agent (the cationic PAMAM dendrimer) and (ii) the corresponding dendrimer/DNA ...
Ainalem, Marie Louise, Campbell, Richard A., Khalid, Syma, Gillams, Richard J., Rennie, Adrian R., Nylander, Tommy   +5 more
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Thermodynamic Analysis of PAMAM Dendrimer Synthesis

2023
The objective of this research was to determine kinetic and thermodynamic data about the reaction between ethylene diamine and methyl acrylate which is used in the production of PAMAM dendrimers. Establishing a rate law and finding values such as rate constant, activation energy, and Arrhenius coefficient will help in determining the best possible ...
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