Results 181 to 190 of about 19,976 (221)

PAMAM dendrimers: A multifunctional nanomaterial for ECL biosensors

Talanta, 2017
Polyamido amine (PAMAM) dendrimers have been shown to function as electrochemiluminescence (ECL) co-reactant and have the inherent capability of improving immobilization of molecules on surfaces due to their dendritic structure. Here, we investigated the combination of both of these properties as the basis for biosensor development.
Sudeshna, Chandra, Michael, Mayer, Antje J, Baeumner   +2 more
openaire   +2 more sources

PAMAM Dendrimers as Delivery Agents for Antisense Oligonucleotides

Pharmaceutical Research, 1999
To investigate the potential use of PAMAM dendrimers for the delivery of antisense oligonucleotides into cells under conditions that mimic the in vivo environment.We used HeLa cells stably transfected with plasmid pLuc/705 which has a luciferase gene interrupted by a human beta-globin intron mutated at nucleotide 705, thus causing incorrect splicing ...
H, Yoo, P, Sazani, R L, Juliano
openaire   +2 more sources

The influence of surface modification on the cytotoxicity of PAMAM dendrimers

International Journal of Pharmaceutics, 2003
The influence of surface modification on the cytotoxicity of PAMAM dendrimers was examined using Caco-2 cells. Dendrimers were modified by conjugating either lauroyl chains or polyethylene glycol (PEG) 2000 onto the surface of cationic PAMAM dendrimers (G2, G3, G4).
Jevprasesphant, R., Penny, J., Jalal, R., Attwood, D., McKeown, N. B., D'Emanuele, A.   +5 more
openaire   +2 more sources

Mechanism of PAMAM Dendrimers Internalization in Hippocampal Neurons

Molecular Pharmaceutics, 2016
Polyamidoamine (PAMAM) dendrimers are hyperbranched macromolecules which have been described as one of the most promising drug nanocarrier systems. A key process to understand is their cellular internalization mechanism because of its direct influence on their intracellular distribution, association with organelles, entry kinetics, and cargo release ...
Felipe, Vidal, Pilar, Vásquez, Carola, Díaz, Daniela, Nova, Joel, Alderete, Leonardo, Guzmán   +5 more
openaire   +2 more sources

Fluorescence emission from PAMAM and PPI dendrimers

Journal of Colloid and Interface Science, 2007
A strong fluorescence emission from poly(amido amine) (PAMAM) dendrimers with different terminal groups or a poly(propylene imine) (PPI) dendrimer was studied under different conditions by varying experimental parameters such as pH value, aging time, temperature, and concentration.
Dongjun, Wang, Toyoko, Imae, Masao, Miki
openaire   +2 more sources

DNA Assisted Self-Assembly of PAMAM Dendrimers

The Journal of Physical Chemistry B, 2014
We report DNA assisted self-assembly of polyamidoamine (PAMAM) dendrimers using all atom Molecular Dynamics (MD) simulations and present a molecular level picture of a DNA-linked PAMAM dendrimer nanocluster, which was first experimentally reported by Choi et al. (Nano Lett., 2004, 4, 391-397). We have used single stranded DNA (ssDNA) to direct the self-
Mandal, Taraknath, Kumar, Mattaparthi Venkata Satish, Maiti, Prabal K   +2 more
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PAMAM Dendrimers for siRNA Delivery: Computational and Experimental Insights

Chemistry – A European Journal, 2010
AbstractShort double‐stranded RNAs, which are known as short interfering RNA (siRNA), can be used to specifically down‐regulate the expression of the targeted gene in a process known as RNA interference (RNAi). However, the success of gene silencing applications based on the use of synthetic siRNA critically depends on efficient intracellular delivery.
Pavan GM, POSOCCO, PAOLA, Tagliabue A., Maly M., Malek A., Danani A., Ragg E., Catapano C. V., PRICL, SABRINA   +8 more
openaire   +5 more sources

Supramolecular mimetic peroxidase based on hemin and PAMAM dendrimers

Chem. Commun., 2008
An acid-base interaction between hemin and PAMAM dendrimers affords supramolecular non-covalent peroxidase systems whose catalytic activity is enhanced after spontaneous electrostatic self-assembling onto a solid surface.
CASTRICIANO MA, ROMEO, Andrea, BARATTO MC, POGNI R, MONSU' SCOLARO, Luigi   +4 more
openaire   +7 more sources

Self‐assembled PAMAM dendrimer films

Advanced Materials, 1997
Self‐assembly of starburst dendrimers into closely packed cells (see the optical micrograph in the Figure) is reported for generation 9.5 polyamidoamine (PAMAM) dendrimers solvent‐cast onto hydrophilic silicon substrates. It is shown that on the microscopic scale the cells are made up of a complex network of intertwined dendritic microfibrils ...
Simon A. Evenson, Jas Pal S. Badyal
openaire   +1 more source

Influence of PAMAM dendrimers on the human insulin

AIP Conference Proceedings, 2015
Dendrimers are specific class of polymeric macromolecules with wide spectrum of properties. One of the promising activities of dendrimers involves inhibition of protein fibril formation. Aggregation and fibrillation of insulin occurs in insulin-dependent diabetic patients after repeated administration, due to these processes being very easily triggered
Olga Nowacka, Katarzyna Miłowska, Maksim Ionov, Maria Bryszewska   +3 more
openaire   +1 more source