Results 181 to 190 of about 7,965 (226)

The influence of surface modification on the cytotoxicity of PAMAM dendrimers

International Journal of Pharmaceutics, 2003
The influence of surface modification on the cytotoxicity of PAMAM dendrimers was examined using Caco-2 cells. Dendrimers were modified by conjugating either lauroyl chains or polyethylene glycol (PEG) 2000 onto the surface of cationic PAMAM dendrimers (G2, G3, G4).
Jevprasesphant, R., Penny, J., Jalal, R., Attwood, D., McKeown, N. B., D'Emanuele, A.   +5 more
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The role of autophagy in the neurotoxicity of cationic PAMAM dendrimers

Biomaterials, 2014
Poly(amidoamine) (PAMAM) dendrimers, are among the most common classes of dendrimers that are intended for a wide range of biomedical applications and extensively investigated for brain-specific drug delivery, imaging and diagnosis. Unfortunately, neurotoxicity of PAMAM dendrimers, the underlying mechanism of which is poorly-elucidated, poses a far ...
Shaofei, Wang, Yubin, Li, Jiajun, Fan, Ziyu, Wang, Xian, Zeng, Yun, Sun, Ping, Song, Dianwen, Ju   +7 more
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Fluorescence Analysis Of PAMAM Dendrimers

2023
Despite their lack of conjugation, polyamidoamine (PAMAM) dendrimers are intrinsically fluorescent, and this fluorescent is somewhat manipulable through altering the dendrimer's solvent. This level of fluorescence is dependent on a number of the dendrimer's qualities: the pH of the solvent, the mass percent concentration of the dendrimer in solvent ...
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Association of small aromatic molecules with PAMAM dendrimers

Physical Chemistry Chemical Physics, 2015
Dendrimer pockets enable association by reducing naphthalene hydration even near the dendrimer periphery.
Ryan S, DeFever, Sapna, Sarupria
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PAMAM dendrimers: A multifunctional nanomaterial for ECL biosensors

Talanta, 2017
Polyamido amine (PAMAM) dendrimers have been shown to function as electrochemiluminescence (ECL) co-reactant and have the inherent capability of improving immobilization of molecules on surfaces due to their dendritic structure. Here, we investigated the combination of both of these properties as the basis for biosensor development.
Sudeshna, Chandra, Michael, Mayer, Antje J, Baeumner   +2 more
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PAMAM dendrimers and prospects of their application in medicine

Medicine of Extreme Situations, 2022
Development of drug delivery systems based on branched biocompatible polymers is one of the most promising areas of modern nanopharmaceutics. Researchers have been exploring this area several decades now, and the results of their efforts quickly find their way into production.
EV Popova, DV Krivorotov, RV Gamazkov, AS Radilov   +3 more
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Nanoscale Protein Pores Modified with PAMAM Dendrimers

Journal of the American Chemical Society, 2007
We describe nanoscale protein pores modified with a single hyperbranched dendrimer molecule inside the channel lumen. Sulfhydryl-reactive polyamido amine (PAMAM) dendrimers of generations 2, 3 and 5 were synthesized, chemically characterized, and reacted with engineered cysteine residues in the transmembrane pore alpha-hemolysin.
Hugh, Martin, Helen, Kinns, Nick, Mitchell, Yann, Astier, Rethi, Madathil, Stefan, Howorka   +5 more
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Antioxidant Action by Gold−PAMAM Dendrimer Nanocomposites

Langmuir, 2004
Gold-dendrimer nanocomposites were prepared in the presence of poly(amidoamine) (PAMAM) dendrimer (generation 3, 3.5, 5, and 5.5) via reduction of HAuCl4 with sodium borohydride. The average particle size of the gold nanoparticles was independent of the dendrimer concentration, ranging between 3.0 and 4.3 nm in diameter. The catalytic activities of the
Kunio, Esumi, Hiroko, Houdatsu, Tomokazu, Yoshimura   +2 more
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Convergent Synthesis of Internally Branched PAMAM Dendrimers

Organic Letters, 2005
[reaction: see text] A series of aliphatic internally branched poly(amido amine) dendrons and dendrimers has been synthesized. The internal branching unit was 1,2-propanediamine and a series of PAMAM-type dendrons of the types AB2, AB4, and AB8 were built.
Pittelkow, Michael, Christensen, Jørn Bolstad   +1 more
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Fluorescence emission from PAMAM and PPI dendrimers

Journal of Colloid and Interface Science, 2007
A strong fluorescence emission from poly(amido amine) (PAMAM) dendrimers with different terminal groups or a poly(propylene imine) (PPI) dendrimer was studied under different conditions by varying experimental parameters such as pH value, aging time, temperature, and concentration.
Dongjun, Wang, Toyoko, Imae, Masao, Miki
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