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Self-assembling of DNA and PAMAM dendrimer
2005 IEEE Engineering in Medicine and Biology 27th Annual Conference, 2005The self-assembling of DNA and cationic polymers are of interest for their biological applications. In this paper, the interaction of DNA with PAMAM was studied by agarose gel electrophoresis, size and zeta-potential measurements and circular dichroism (CD) spectroscopy. DNA was shown to form stable complexes with PAMAM by gel electrophoresis. The mean
L Z, Zhou, X L, Yang, L, Gan, H B, Xu
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Incorporation of fluorescent probes into PAMAM dendrimers
Bioelectrochemistry, 2004Interactions of two fluorescent probes 1-(trimethylammoniumphenyl)-6-phenyl-1,3,5 hexatriene p-toluenesulfonate (TMA-DPH) and 12-(9-anthroyloxy) stearic acid (12-AS) with polyamidoamine (PAMAM) dendrimers were studied. Changes in fluorescence intensity and steady-state fluorescence anisotropy of TMA-DPH and 12-AS were monitored. It was found that 12-AS
D M, Domański +2 more
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Design considerations for PAMAM dendrimer therapeutics
Bioorganic & Medicinal Chemistry Letters, 2013We have previously shown that methotrexate (MTX) conjugated to a cancer-specific poly amido amine (PAMAM) dendrimer has a higher therapeutic index than MTX alone. Unfortunately, these therapeutics have been difficult to advance because of the complicated syntheses and an incomplete understanding of the dendrimer properties.
Sascha N, Goonewardena +7 more
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Application of PAMAM dendrimers in optical sensing
The Analyst, 2015In this review, recent advances have been reported in those PAMAM dendrimer-based optical sensors that are used for the detection of pH, cations, and other analyte.
E, Soršak +3 more
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Toxicity of PAMAM dendrimers to Chlamydomonas reinhardtii
Aquatic Toxicology, 2010In recent decades, a new class of polymeric materials, PAMAM dendrimers, has attracted marked interest owing to their unique nanoscopic architecture and their hopeful perspectives in nanomedicine and therapeutics. However, the potential release of dendrimers into the aquatic environment raises the issue about their toxicity on aquatic organisms.
Anne-Noëlle, Petit +3 more
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Journal of Biomaterials Science, Polymer Edition, 2015
Achieving biomimetic mineralization of collagen fibrils by mimicking the role of non-collagenous proteins (NCPs) with biomimetic analogs is of great interest in the fields of material science and stomatology. Amine-terminated PAMAM dendrimer (PAMAM-NH2), which possesses a highly ordered architecture and many calcium coordination sites, may be a ...
Kunneng, Liang +6 more
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Achieving biomimetic mineralization of collagen fibrils by mimicking the role of non-collagenous proteins (NCPs) with biomimetic analogs is of great interest in the fields of material science and stomatology. Amine-terminated PAMAM dendrimer (PAMAM-NH2), which possesses a highly ordered architecture and many calcium coordination sites, may be a ...
Kunneng, Liang +6 more
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2005
(MW ) (high loading beads;1 single bead analysis;2, 3 water compatible, synthesis of peptides;1-3 dendrimer-chlorambucil conjugate;3 aryl ethers;4 amidines-based GP IIb-IIa antagonists;5 benzodiazepinone derivatives;6 diketopiperazine;7 secondary amide;6 biaryl;6 tetrazole;6 site-site interactions.7) Alternate Name: DendroGel.4
Siew-Eng How, Mark Bradley
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(MW ) (high loading beads;1 single bead analysis;2, 3 water compatible, synthesis of peptides;1-3 dendrimer-chlorambucil conjugate;3 aryl ethers;4 amidines-based GP IIb-IIa antagonists;5 benzodiazepinone derivatives;6 diketopiperazine;7 secondary amide;6 biaryl;6 tetrazole;6 site-site interactions.7) Alternate Name: DendroGel.4
Siew-Eng How, Mark Bradley
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CuO nanoparticles with PAMAM dendrimers
Journal of Coordination Chemistry, 2016AbstractAn easy pathway to synthesize a variety of cupric oxide (CuO) nanoshapes by a one-step wet chemical method is reported. CuO nanoparticles and nanorods were obtained from CuCl2 in a mixture of water and DMSO in the absence of a base at room temperature.
A. R. Vázquez-Olmos +4 more
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Journal of Pharmaceutical Sciences, 2015
PAMAM (polyamidoamine) dendrimers are commonly considered promising polymers that can be successfully used in various biomedical applications. Nevertheless, direct clinical adaptations of plain unmodified PAMAM dendrimers may be limited at present, mainly because of their toxicity, unpredictable behavior in living organisms, unknown bioavailability ...
Magdalena, Labieniec-Watala +1 more
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PAMAM (polyamidoamine) dendrimers are commonly considered promising polymers that can be successfully used in various biomedical applications. Nevertheless, direct clinical adaptations of plain unmodified PAMAM dendrimers may be limited at present, mainly because of their toxicity, unpredictable behavior in living organisms, unknown bioavailability ...
Magdalena, Labieniec-Watala +1 more
openaire +2 more sources