Results 191 to 200 of about 13,061 (210)

DNA-Templated Covalent Coupling of G4 PAMAM Dendrimers

Journal of the American Chemical Society, 2010
Generation-4 polyamidoamine (PAMAM) dendrimers were surface-functionalized with azides or alkynes and conjugated to one DNA strand. DNA-controlled self-assembly of alternating azide and alkyne dendrimers on a DNA template enabled the coupling of the dendrimers by the azide-alkyne "click" reaction to form covalently coupled dimers, trimers, and ...
Liu, Huajie, Tørring, Thomas, Dong, Mingdong, Rosen, Christian B, Besenbacher, Flemming, Gothelf, Kurt V   +5 more
openaire   +2 more sources

HPLC analysis of PAMAM dendrimer based multifunctional devices

Journal of Chromatography B, 2005
Comprehensive high-performance liquid chromatography (HPLC) analyses were performed on poly(amidoamine) (PAMAM) dendrimer based multifunctional devices. The nanometer-size devices were synthesized by conjugating partially acetylated (Ac) poly(amidoamine) dendrimers of generation 5 (G5) with fluorescein isothiocyanate (FITC), folic acid (FA) and ...
Mohammad T, Islam, Istvan J, Majoros, James R, Baker   +2 more
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Stable hemiaminals attached to PAMAM dendrimers

Tetrahedron Letters, 2009
Abstract Stable hemiaminals (carbinolamines) are formed during the reaction between aromatic aldehydes and amine groups on the surface of polyamidoamino dendrimers in methanol under mild conditions, as monitored by 1 H NMR spectroscopy.
Paweł Subik, Barbara Welc, Beata Wisz, Stanisław Wołowiec   +3 more
openaire   +1 more source

Mechanism of PAMAM Dendrimers Internalization in Hippocampal Neurons

Molecular Pharmaceutics, 2016
Polyamidoamine (PAMAM) dendrimers are hyperbranched macromolecules which have been described as one of the most promising drug nanocarrier systems. A key process to understand is their cellular internalization mechanism because of its direct influence on their intracellular distribution, association with organelles, entry kinetics, and cargo release ...
Felipe, Vidal, Pilar, Vásquez, Carola, Díaz, Daniela, Nova, Joel, Alderete, Leonardo, Guzmán   +5 more
openaire   +2 more sources

PAMAM dendrimers: A multifunctional nanomaterial for ECL biosensors

Talanta, 2017
Polyamido amine (PAMAM) dendrimers have been shown to function as electrochemiluminescence (ECL) co-reactant and have the inherent capability of improving immobilization of molecules on surfaces due to their dendritic structure. Here, we investigated the combination of both of these properties as the basis for biosensor development.
Sudeshna, Chandra, Michael, Mayer, Antje J, Baeumner   +2 more
openaire   +2 more sources

Performance evaluation of PAMAM dendrimer based simvastatin formulations

International Journal of Pharmaceutics, 2011
The purpose of this investigation was to evaluate the performance of poly (amidoamine) (PAMAM) dendrimers, with three different surface groups, to be used as drug carriers. Drug-dendrimers complexes were investigated for solubility studies, dissolution studies, in vitro drug release studies, and for stability studies.
Hitesh, Kulhari, Deep, Pooja, S K, Prajapati, Abhay Singh, Chauhan   +3 more
openaire   +2 more sources

Thermodynamic Analysis of PAMAM Dendrimer Synthesis

2023
The objective of this research was to determine kinetic and thermodynamic data about the reaction between ethylene diamine and methyl acrylate which is used in the production of PAMAM dendrimers. Establishing a rate law and finding values such as rate constant, activation energy, and Arrhenius coefficient will help in determining the best possible ...
openaire   +1 more source

Interactions between PAMAM dendrimers and bovine serum albumin

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2003
Dendrimers are a new class of polymeric materials. They are globular, highly branched, monodisperse macromolecules. Due to their structure, dendrimers promise to be new, effective biomedical materials as oligonucleotide transfection agents and drug carriers. More information about biological properties of dendrimers is crucial for further investigation
Barbara, Klajnert, Lidia, Stanisławska, Maria, Bryszewska, Bartłomiej, Pałecz   +3 more
openaire   +2 more sources

Molecular simulation study of PAMAM dendrimer composite membranes

Journal of Molecular Modeling, 2014
Pure polysulfone (PSF) and its composites with chitosan (CST), hyaluronic acid (HA), conventional poly(amidoamine), and hydroxyl poly(amidoamine) dendrimers as the membranes for separation of the gases, methane, carbon dioxide, hydrogen sulfide, nitrogen, and oxygen have been studied by molecular dynamics (MD) and grand canonical Monte Carlo (GCMC ...
Sepideh, Amjad-Iranagh, Karim, Golzar, Hamid, Modarress   +2 more
openaire   +2 more sources

Surface modification of PAMAM dendrimer improves its biocompatibility

Nanomedicine: Nanotechnology, Biology and Medicine, 2012
Modification of dendrimer surface groups is one of the methods available to obtain compounds characterized by reduced toxicity. This article reports results of preliminary biocompatibility studies of a modified polyamidoamine dendrimer of the fourth generation.
Ciolkowski, Michal, Petersen, Johannes F., Ficker, Mario, Janaszewska, Anna, Christensen, Jørn Bolstad, Klajnert, Barbara, Bryszewska, Maria   +6 more
openaire   +3 more sources