Results 101 to 110 of about 81,947 (284)

HIV-1 structural proteins serve as PAMPs for TLR2 heterodimers significantly increasing infection and innate immune activation

Frontiers in Immunology, 2015
Immune activation is critical to HIV infection and pathogenesis; however, our understanding of HIV innate immune activation remains incomplete. Recently we demonstrated that soluble TLR2 (sTLR2) physically inhibited HIV-induced, NFκB activation and ...
Kenneth Lee Rosenthal, Bethany M Henrick, Xiao-Dan eYao   +2 more
doaj   +1 more source

Synthetic Cathepsin B Sensitive Adjuvant‐Peptide Conjugates to Target Intracellular Toll‐Like Receptors 7 and 8

ChemistryEurope, EarlyView.
Cathepsin B‐sensitive peptide–adjuvant conjugates are designed, synthesized, and evaluated to deliver an antigenic peptid and an adjuvant targeting Toll‐like receptors 7 and 8 (TLR7/8) to antigen presenting cells. The adjuvant is released by cathepsin B resulting in antigen presentation and TLR mediated T cell activation.
Marjolein M. E. Isendoorn, Giulia Castello, Nico J. Meeuwenoord, Martijn Verdoes, Jeroen D. C. Codée, Ferry Ossendorp, Dmitri V. Filippov   +6 more
wiley   +1 more source

RORγt‐APCs: The New Masters of Oral Tolerance

Barrier Immunity, EarlyView.
ABSTRACT Oral tolerance is defined by the hypo‐responsiveness of our body to fed antigens, and its failure can lead to immune‐mediated diseases, such as allergy, chronic inflammation and autoimmune diseases. Decades of research have demonstrated that antigen‐presenting cells (APCs) promote oral tolerance by inducing regulatory T cells (Tregs) and/or ...
Thierry Gauthier, WanJun Chen
wiley   +1 more source

Development of Highly pH-Sensitive Hybrid Membranes by Simultaneous Electrospinning of Amphiphilic Nanofibers Reinforced with Graphene Oxide

Journal of Functional Biomaterials, 2019
: Nanofibrous-based pH sensors have shown promise in a wide range of industrial and medical applications due to their fast response time and good mechanical properties.
Mohsen Gorji, Ali Sadeghianmaryan, Hossein Rajabinejad, Saman Nasherolahkam, Xiongbiao Chen   +4 more
doaj   +1 more source

Cardiac remodelling in the era of the recommended four pillars heart failure medical therapy

ESC Heart Failure, Volume 12, Issue 2, Page 1029-1044, April 2025.
Abstract Cardiac remodelling is a key determinant of worse cardiovascular outcome in patients with heart failure (HF) and reduced ejection fraction (HFrEF). It affects both the left ventricle (LV) structure and function as well as the left atrium (LA) and the right ventricle (RV).
Giada Colombo, Tor Biering‐Sorensen, Joao P. Ferreira, Carlo Mario Lombardi, Andrea Bonelli, Andrea Garascia, Marco Metra, Riccardo M. Inciardi   +7 more
wiley   +1 more source

Hepatocyte Toll‐like receptors contribute to the hepcidin inflammatory response to pathogens and pathogen‐derived ligands

HemaSphere
Iron restriction is a critical pathomechanism underlying the Anemia of Inflammation and an innate immune response limiting the replication of extracellular pathogens.
Katharina Bonitz, Silvia Colucci, Ruiyue Qiu, Sandro Altamura, Richard Sparla, Katja Mudder, Stefan Zimmermann, Matthias W. Hentze, Martina U. Muckenthaler, Oriana Marques   +9 more
doaj   +1 more source

Macroautophagy during innate immune activation

Frontiers in Cellular and Infection Microbiology, 2011
Innate immune activation is initiated by recognition of pathogen associated molecular patterns (PAMPs). Delivery of PAMPs to their respective receptors, regulation of receptor activity and effector functions downstream from these receptors, which ...
Christian eMunz
doaj   +1 more source

Gut‐microbiota‐brain Axis and post‐traumatic epilepsy

Epilepsia Open, EarlyView.
Abstract There has been growing evidence that perturbations in gut‐microbiota‐brain axis (GMBA) are involved in mechanisms of chronic sequelae of traumatic brain injury (TBI). This review discusses the connection between GMBA and post‐traumatic epilepsy (PTE), the latter being a common outcome of TBI.
Andrey Mazarati
wiley   +1 more source

Alarmins, inflammasomes and immunity

Biomedical Journal, 2012
The elaboration of an effective immune response against pathogenic microbes such as viruses, intracellular bacteria or protozoan parasites relies on the recognition of microbial products called pathogen-associated molecular patterns (PAMPs) by pattern ...
Najwane Saïd-Sadier, David M Ojcius
doaj   +1 more source

Recent Advances in Conjugated Microporous Polymers for Photocatalysis: Mechanism, Synthesis and Applications

Exploration, EarlyView.
Conjugated microporous polymers (CMPs) have attracted more and more attention as new photocatalysts due to their unique advantages such as high performance, long stability and strong light absorption. This review summarizes the application of CMPs as a photocatalyst in recent years and introduces the catalytic mechanism.
Dun Zhou, Kongqing Zhang, Xiaobai Li, Yongpeng Liu, Liang Yao, Hongwei Ma   +5 more
wiley   +1 more source