Results 61 to 70 of about 39,007 (262)

Neuro-fuzzy control for artificial pancreas: in silico development and validation

Revista Iberoamericana de Automática e Informática Industrial RIAI, 2020
Type 1 Diabetes Mellitus (DMT1) is currently one of the most harmful diseases that aect people of any age, including children from birth. Exogenous insulin injections remain the most common treatment for these patients, however, it is not the optimal one.
Y. Rios, J. García-Rodríguez, E. Sánchez, A. Alanis, E. Ruiz-Velázquez, A. Pardo   +5 more
doaj   +1 more source

Organ‐Specific and Conserved Regulatory Logic Orchestrates Gene Expression in the Embryonic Mesothelium

Advanced Science, EarlyView.
Integrated multi‐omic profiling maps the gene‐regulatory landscape of the coelomic mesothelium across heart, lung, and pancreas. A cardiac‐restricted regulatory program is uncovered in which TBX20 activates heart mesothelial (epicardial) cis‐regulatory elements, while MAF emerges as a conserved regulator of mesothelial identity.
Quang Minh Dang, Nicola Smart, Andia Nicole Redpath, Joaquim Miguel Vieira   +3 more
wiley   +1 more source

The artificial pancreas: From logic to life [PDF]

, 2017
In this thesis we investigated the efficacy of real-life use of an artificial pancreas starting with use of these systems in a hotel setting and finally 24/7 long-term use at home.
Kropff, Jort, Kropff, J.
core  

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Safety of artificial pancreas in hepato-biliary-pancreatic surgery: A prospective study

Asian Journal of Surgery, 2020
Background: An artificial pancreas (AP) is useful for intensive insulin treatment (IIT). In this study, the safety and efficacy of an AP in the perioperative period of highly invasive hepato-biliary and pancreatic surgery (HBPS) was validated.
Hironori Hayashi, Hidehiro Tajima, Kazuhiro Hanazaki, Hiroyuki Takamura, Ryosuke Gabata, Mitsuyoshi Okazaki, Yoshinao Ohbatake, Shinichi Nakanuma, Isamu Makino, Tomoharu Miyashita, Itasu Ninomiya, Sachio Fushida, Kenichi Yoshimura, Tetsuo Ohta   +13 more
doaj   +1 more source

In silico validation of a customizable fully-autonomous artificial pancreas with coordinated insulin, glucagon and rescue carbohydrates [PDF]

[EN] Artificial pancreas systems should be designed considering different patient profiles, which is challenging from a control theory perspective. In this paper, a flexible-hybrid dual-hormone control algorithm for an artificial pancreas is proposed ...
García Gil, Pedro José, Diez, José-Luís, Sanz Diaz, Ricardo, Furió-Novejarque, Clara, Bondía Company, Jorge, Sala-Mira, Iván   +5 more
core   +1 more source

An artificial pancreas for automated blood glucose control in patients with Type 1 diabetes [PDF]

, 2015
Automated glucose control in patients with Type 1 diabetes is much-coveted by patients, relatives and healthcare professionals. It is the expectation that a system for automated control, also know as an artificial pancreas, will improve glucose control ...
Ranjan, Ajenthen, Schmidt, Signe, Jørgensen, John Bagterp, Madsen, Henrik, Boiroux, Dimitri, Nørgaard, Kirsten   +5 more
core   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu, Lingyao Zeng, Xulin Gan, Yilin Zhou, Han Shen, Dan Wu, Xin Shou, Minmin Jiang, Liyun Shi   +8 more
wiley   +1 more source

The Artificial Pancreas Today

, 1983
An artificial pancreas is now available in selected centers for clinical use in blood glucose control. With information derived from 24-30 hours of closed-loop insulin administration by means of the artificial pancreas, subcutaneous insulin doses may ...
McMurry, James F., Jr.
core