Results 71 to 80 of about 39,007 (262)

Selective Targeting of Immune Checkpoints HLA‐G and CD47 Using Novel Dual Signaling Protein DSP216 Promotes Innate Anticancer Immunity

Advanced Science, EarlyView.
The inhibitory immune checkpoints HLA‐G and CD47 are expressed on certain tumor types and inhibit immune cells in the tumor microenvironment. DSP216 binds specifically to cancer cells expressing both HLA‐G and CD47, and blocks their inhibitory signaling.
Lisa J. Jacob, Liat Tamir, Mufeed Abdeen, Ami Tamir, Alexandra Aronin, Itai Bloch, Roy Kahn, Iris Pecker, Mark Tykocinski, Gerwin Huls, Yaron Pereg, Ayelet Chajut, Edwin Bremer   +12 more
wiley   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Closed‐Loop Bioelectronic Artificial Pancreas Patch for Continuous Monitoring and Regulation of Blood Glucose in Diabetic Rats and Pigs

Advanced Science
Integrated artificial pancreas devices with continuous glucose monitoring (CGM) and closed‐loop insulin delivery are crucial for diabetes management.
Yiqun Liu, Changxi Zhang, Lingyi Xu, Yuan Ma, Yuanyuan Ma, Ying Chen, Difei Lu, Le Ye, Li Yang, Yue Cui   +9 more
doaj   +1 more source

Assessing Implantation Sites for Pancreatic Islet Cell Transplantation: Implications for Type 1 Diabetes Mellitus Treatment

Bioengineering
Type 1 diabetes mellitus (T1DM) involves the destruction of pancreatic β-cells, requiring ongoing insulin therapy. A promising alternative for management is pancreatic islet transplantation, or the bioartificial pancreas.
Vinícius Gabriel Silvério Scholl, Leonardo Todeschini Justus, Otávio Simões Girotto, Kelly Karine Pasqual, Matheus Henrique Herminio Garcia, Fernando Gonçalves da Silva Petronio, Aline Flores de Moraes, Sandra Maria Barbalho, Adriano Cressoni Araújo, Lucas Fornari Laurindo, Cristina Pires Camargo, Maria Angélica Miglino   +11 more
doaj   +1 more source

Integrated real time bowel sound detector for artificial pancreas systems

Sensing and Bio-Sensing Research, 2016
This paper reports an ultra-low power real time bowel sound detector with integrated feature extractor for physiologic measure of meal instances in artificial pancreas devices.
Khandaker A. Al Mamun, Nicole McFarlane
doaj   +1 more source

DIY artificial pancreas systems: the clinician perspective.

, 2020
We are witnessing a technological revolution in type 1 diabetes, with a race to bring commercial closed-loop (artificial pancreas) systems to market. However, only one automated insulin-delivery system, the Medtronic MiniMed 670G, has received both US ...
Wilmot, Emma
core   +1 more source

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

Intraperitoneal insulin infusion: on the way to the artificial pancreas

Сахарный диабет, 2015
Creating an "artificial pancreas" (a "closed loop" insulin pump, with self-adjusting insulin abilities, based on real time continuous glucose monitoring data) – is one of the most actual medical challenges of modern engineering and cybernetics.Artificial
Vladimir Aleksandrovich Karpel'ev, Elena Anatol'evna Fedorova, Yury Ivanovich Philippov, Aleksandr Yur'evich Mayorov, Marina Vladimirovna Shestakova   +4 more
doaj   +1 more source

Large‐Scale Genomics Reveals Three‐Source Ancestry and Layered Adaptation to High Altitude in Tibetan Chickens

Advanced Science, EarlyView.
Whole‐genome analysis of 1,054 chickens reveals three ancestral sources (NWC, SYA, and SHF) with distinct temporal entry patterns into the Tibetan Plateau. Route‐specific selection scans, calibrated against a demographic null, suggest complementary functional enrichments—vascular homeostasis (NWC), calcium signaling and cardiac adaptation (SYA), and ...
Zongyi Zhao, Ruixue Nie, Hailu Fan, Tenzin Ngodroup, Li Zhu, Hongbin Pan, Bo Zhang, Hao Zhang   +7 more
wiley   +1 more source

The Artificial Pancreas (semester?), IPRO 308: Developing an Artificial Pancreas IPRO 308 Project Plan F06

, 2006
The objective of this IPRO is to develop a system that will function as an artificial pancreas and will incorporate an insulin delivery system with a non invasive glucose monitor.Deliverables for IPRO 308: The Artificial Pancreas for the Fall 2006 ...
Miller, Jennifer, Ravuri, Venkata, Vinckevicious, Aurimes, Tanner, Ryan, Patel, Sapna, Patel, Shital C., Pathak, Yagna, Nazim, Mehjabeen, Reddy, Kirthi, Davis, Elena, Shivakumar, Vidya   +10 more
core