Results 1 to 10 of about 25,336 (285)
Detection of human elastase isoforms by the ScheBo Pancreatic Elastase 1 Test. [PDF]
Am J Physiol Gastrointest Liver Physiol, 2017 Determination of fecal pancreatic elastase content by ELISA is a reliable, noninvasive clinical test for assessing exocrine pancreatic function. Despite the widespread use of commercial tests, their exact molecular targets remain poorly characterized.
Tóth AZ +4 more
europepmc +5 more sources
Understanding the Impact of Ostomy Dejecta Constituents on Peristomal Skin Health and Models for Its Characterisation. [PDF]
Int Wound JABSTRACT An ostomy, or stoma, is a surgically created percutaneous aperture from a hollow organ (e.g., small intestine) to the body's surface. Physicians may recommend an ostomy as a temporary or permanent solution to a range of disorders of the gastrointestinal tract, with up to 130 000 ostomies performed annually in the United States.
Ejiugwo MA +5 more
europepmc +2 more sources
Molecular Elucidation of Pancreatic Elastase Inhibition by Baicalein [PDF]
Journal of Biomolecular Structure and Dynamics, 2020 ABSTRACTThe serine protease, elastase exists in various forms and plays diverse roles in the human body. Pharmacological inhibition of elastase has been investigated for its therapeutic role in managing conditions such as diabetes, pneumonia and arthritis.
Rakesh Joshi +6 more
openaire +5 more sources
The specificity of purified porcine pancreatic elastase [PDF]
Biochemical Journal, 1969 An electrophoretically homogeneous elastase preparation free from tryptic and chymotryptic activities was obtained by chromatography on DEAE-Sephadex and CM-cellulose. This preparation exhibits a narrower specificity towards peptide bonds than that observed by Naughton & Sanger (1961).
A. Sampath Narayanan, R. A. Anwar
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Studies on porcine pancreatic elastase activity. I. Radioimmuoassay of porcine pancreatic elastase.
The Tohoku Journal of Experimental Medicine, 1980 An improved method of radioimmunoassay was devised to offer a successful formula for determining blood concentration of elastase. With porcine pancreatic elastase as the antigen, rabbits were immunized to obtain antiserum. Iodinated elastase labeled by the chloramine-T procedure using 131I (or 125I) had a specific activity of 200-300 mCi/mg. The double
Yoichi Saitor +4 more
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The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
Faecal elastase 1 in chronic pancreatitis [PDF]
Gut, 1999 Editor,—I read with interest the recent paper by Lankisch et al ( Gut 1998; 42 :551–4). The authors studied faecal elastase 1 and faecal chymotrypsin in 30 patients with chronic pancreatitis and concluded that the estimation of faecal elastase 1 is not helpful in diagnosing mild and moderate exocrine pancreatic insufficiency and that this enzyme is not
L GULLO, P G LANKISCH
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Endostatin expression in pancreatic tissue is modulated by elastase [PDF]
British Journal of Cancer, 2004 Pancreatic tumours are scirrhous, avascular tumours, suggesting that they may produce angiogenesis inhibitors that suppress the growth of the vasculature to the tumour and metastases. We have sought evidence for the angiogenesis inhibitor, endostatin, in normal and cancerous pancreatic tissue.
Simon R. Bramhall, R D Brammer, M C Eggo
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Advanced Science, EarlyView.This study highlights the critical role of IRF8 in the development of AAA. IRF8 activation promotes the differentiation of cDC1s, which in turn recruit and activate CD8+ T cells, contributing to aortic wall degradation. The study identifies the IRF8‐cDC1‐CD8+ T cell axis as a key pathway in AAA progression, offering new potential therapeutic targets to
Zhen Yuan +11 more
wiley +1 more source
Advanced Science, EarlyView.Gasdermin D (GSDMD) does not only reduce pancreatic enzyme synthesis but also induces pancreatic acinar cells to express mucin 1 (MUC1), which forms a barrier to prevent digestive enzyme‐mediated digestion. However, GSDMD can promote the secretion of inflammatory cytokines by macrophages and aggravate pancreatic histological injury by expanding ...
Chaoxu Liu +10 more
wiley +1 more source