Results 31 to 40 of about 14,407 (231)

Safety evaluation of a food enzyme containing trypsin, chymotrypsin, elastase and carboxypeptidase from porcine pancreas

EFSA Journal, 2021
The food enzyme is a protease complex, containing trypsin (EC 3.4.21.4), chymotrypsin (EC 3.4.21.1), pancreatic elastase (EC 3.4.21.36) and carboxypeptidase B (EC 3.4.17.2), obtained from porcine pancreas by Neova Technologies Inc.
EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP), Vittorio Silano, José Manuel Barat Baviera, Claudia Bolognesi, Pier Sandro Cocconcelli, Riccardo Crebelli, David Michael Gott, Konrad Grob, Claude Lambré, Evgenia Lampi, Marcel Mengelers, Alicja Mortensen, Gilles Rivière, Inger‐Lise Steffensen, Christina Tlustos, Henk Van Loveren, Laurence Vernis, Holger Zorn, Ursula Gundert‐Remy, Lieve Herman, Dominique Turck, Karl‐Heinz Engel, Margarita Aguilera‐Gómez, Magdalena Andryszkiewicz, Natalia Kovalkovicova, Yi Liu, Joaquim Maia, Sandra Rainieri, Andrew Chesson   +28 more
doaj   +1 more source

Clinical results of application of lymphotropic antibioticotherapy in patients with an acute pancreatitis

Український журнал клінічної хірургії, 2023
Objective.. To compare the clinical results of application of lymphotropic therapy and standard procedure of parenteral introduction of preparations. Materials and methods.
I. D. Duzhyi, O. L. Sytnik, G. I. Piatikop   +2 more
doaj   +1 more source

Secondary exocrine pancreatic insufficiency. Features of the choice of the enzyme

Медицинский совет, 2021
Exocrine pancreatic insufficiency is quite common in clinical practice of doctors of many specialties. Decrease in intraduodenal lipase levels below 5–10% of normal leads to pancreatic steatorrhea, weight loss and a potential decrease in quality of life.
I. G. Pakhomova
doaj   +1 more source

Production of Secretory Leucocyte Protease Inhibitor (SLPI) in Human Pancreatic β-Cells

Mediators of Inflammation, 1999
Secretory leucocyte protease inhibitor (SLPI) is a potent inhibitor of granulocyte elastase and cathepsin G, and also an inhibitor of pancreatic enzymes like trypsin, chymotrypsin and pancreatic elastase.
Max Nyström, Magnus Bergenfeldt, Irena Ljungcrantz, Èsa Lindeheim, Kjell Ohlsson   +4 more
doaj   +1 more source

Prevalence of end-organ damage, beta cell reserve, and exocrine pancreas defect in fibrocalculous pancreatic diabetes: An Eastern India perspective

Indian Journal of Endocrinology and Metabolism, 2019
Background: Data on prevalence and burden of end-organ damage in fibrocalculous pancreatic diabetes (FCPD) from eastern India is scant. This study investigated the burden of end-organ damage and exocrine pancreatic defect in FCPD patients in Eastern ...
Beatrice Anne, Sujoy Ghosh, Ipsita Ghosh, Sayantan Ray, Subhankar Chowdhury, Deep Dutta   +5 more
doaj   +1 more source

Evaluation of Ionic Liquids and Ionic Liquids Active Pharmaceutical Ingredients Inhibition in Elastase Enzyme Activity

Molecules, 2021
Human neutrophil elastase (HNE) is used as diagnostic biomarker for inflammation/infection. In this work, 10 ionic liquids (ILs) and 11 ionic liquids active pharmaceutical ingredients (ILs-APIs) were tested to evaluate the inhibition effect on the ...
Fátima A. R. Mota, Sarah A. P. Pereira, André R. T. S. Araujo, M. Lúcia M. F. S. Saraiva   +3 more
doaj   +1 more source

Microenvironment Modulation‐Based Nanomaterial‐Loaded Hydrogel Dressings for Diabetic Foot Ulcers: Research Progress and Future Perspectives

Advanced Materials Interfaces, EarlyView.
xx xx. ABSTRACT Diabetic foot ulcer (DFU) is a chronic complication of diabetes, primarily caused by hyperglycemia, peripheral vascular disease, and neuropathy. Characterized by persistent hyperglycemia, impaired perfusion, inflammation, and infection, DFUs pose significant challenges to healing and are associated with high morbidity and amputation ...
Tang Yuqing, Chen Hong, Fan Weijing, Huang Renyan, You Yang, Liu Guobin   +5 more
wiley   +1 more source

Functional Features of the Pancreas during Chronic Pancreatitis

Gastroenterologìa, 2016
Aim of study: to identify functional status of pancreas in patients with chronic pancreatitis depending on the stage of fibrotic transformation and activity of parenchymal inflammation. Materials and methods.
B.F. Shevchenko, A.M. Babiy, O.М. Tatarchuk, V.A. Makarchuk, V.E. Kudryavtseva   +4 more
doaj   +1 more source

Molecular Elucidation of Pancreatic Elastase Inhibition by Baicalein [PDF]

Journal of Biomolecular Structure and Dynamics, 2020
ABSTRACTThe serine protease, elastase exists in various forms and plays diverse roles in the human body. Pharmacological inhibition of elastase has been investigated for its therapeutic role in managing conditions such as diabetes, pneumonia and arthritis.
Debajeet Ghosh, Sneha Bansode, Rakesh Joshi, Baban Kolte, Rajesh Gacche   +4 more
openaire   +3 more sources

Metabolic Reprogramming of T Cells by Dual UCP2 and IL‐17 Blockade Enhances Immunity Against Pancreatic Cancer

Advanced Science, EarlyView.
This study demonstrates that dual UCP2/IL‐17 blockade reprograms T‐cell metabolism to overcome PDAC immunosuppression. Genipin‐mediated UCP2 inhibition enhances CD8⁺ T‐cell IFN‐γ via IL‐12R/STAT4/mTOR signaling and mitochondrial OXPHOS. Combined IL‐17 depletion amplifies Tc1/Th1 responses, reduces MDSCs, and prolongs survival in PDAC models ...
Chuan‐Teng Liu, Chun‐Chieh Yeh, Tsai‐Chen Wu, Chia‐Hsin Lin, Yi‐Ting Kuo, Yoichiro Iwakura, Yuan‐Ji Day, Charles Drake, Vedran Radojcic, Ying‐Chyi Song, Heng‐Hsiung Wu, Hung‐Rong Yen   +11 more
wiley   +1 more source