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Nature Biotechnology, 2022 Transplantation of pancreatic islet cells derived from human pluripotent stem cells is a promising treatment for diabetes. Despite progress in the generation of stem-cell-derived islets (SC-islets), no detailed characterization of their functional ...
Diego Balboa +2 more
exaly +2 more sources
Nature Metabolism, 2022 Type 1 diabetes (T1D) is an autoimmune disease in which immune cells destroy insulin-producing beta cells. The aetiology of this complex disease is dependent on the interplay of multiple heterogeneous cell types in the pancreatic environment.
Gregory W Schwartz +2 more
exaly +2 more sources
A double mechanism for the mesenchymal stem cells' positive effect on pancreatic islets. [PDF]
PLoS ONE, 2014 The clinical usability of pancreatic islet transplantation for the treatment of type I diabetes, despite some encouraging results, is currently hampered by the short lifespan of the transplanted tissue.
Arianna Scuteri +8 more
doaj +2 more sources
Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D
Nature Communications, 2020 Most signals detected by genome-wide association studies map to non-coding sequence and their tissue-specific effects influence transcriptional regulation.
Ana Viñuela +2 more
exaly +2 more sources
Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes
Cell Metabolism, 2016 Summary Hormone-secreting cells within pancreatic islets of Langerhans play important roles in metabolic homeostasis and disease. However, their transcriptional characterization is still incomplete.
Eva-Marie Andersson +2 more
exaly +2 more sources
Microgravity Effect on Pancreatic Islets. [PDF]
CellsWe previously demonstrated that boundary cap neural crest stem cells (BCs) induce the proliferation of beta-cells in vitro, increase survival of pancreatic islets (PIs) in vivo after transplantation, and themselves strongly increase their proliferation capacity after exposure to space conditions.
Zeger L +8 more
europepmc +6 more sources
Pancreatic islet transplantation [PDF]
World Journal of Gastrointestinal Surgery, 2009 Type 1 diabetes mellitus is an autoimmune disease, which results in the permanent destruction of β-cells of the pancreatic islets of Langerhans. While exogenous insulin therapy has dramatically improved the quality of life, chronic diabetic complications develop in a substantial proportion of subjects and these complications generally progress and ...
Corrêa-Giannella Maria +1 more
openaire +5 more sources
Journal of Functional Biomaterials, 2022 Infusing pancreatic islets into the portal vein currently represents the preferred approach for islet transplantation, despite considerable loss of islet mass almost immediately after implantation.
Zuzana Berkova +10 more
doaj +1 more source
Effect of alcohol on insulin secretion and viability of human pancreatic islets [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2017 Introduction/Objective. There are controversial data in the literature on the topic of effects of alcohol on insulin secretion, apoptosis, and necrosis of the endocrine and exocrine pancreas. The goal of this research was to determine how alcohol affects
Nikolić Dragan +4 more
doaj +1 more source
Irisin—A Pancreatic Islet Hormone [PDF]
Biomedicines, 2022 Irisin is a myokine involved in glucose homeostasis. It is primarily expressed in skeletal muscle, but also in the pancreas. This study aimed to elucidate its presence and role in the islets of Langerhans—i.e., its effect on insulin and glucagon secretion as well as on blood flow in the pancreas.
Daniel Norman +3 more
openaire +5 more sources