Results 31 to 40 of about 527,417 (294)

Resident macrophages of pancreatic islets have a seminal role in the initiation of autoimmune diabetes of NOD mice

Proceedings of the National Academy of Sciences of the United States of America, 2017
Significance Our studies indicate that the resident macrophages of the pancreatic islets of Langerhans have a seminal role in the initiation and progression of autoimmune diabetes in NOD mice.
Javier A. Carrero, D. McCarthy, Stephen T. Ferris, Xiaoxiao Wan, Hao Hu, B. Zinselmeyer, Anthony N. Vomund, E. Unanue   +7 more
semanticscholar   +1 more source

Pancreatic islet transplantation

Seminars in Pediatric Surgery, 2012
Pancreatic islet transplantation is a minimally invasive treatment that has the potential to prevent diabetes after total pancreatectomy for benign disease (islet autotransplantation) and to reverse diabetes in those with type 1 diabetes (islet allotransplantation).
Johnson, P, Jones, K
openaire   +2 more sources

Effect of Basic Fibroblast Growth Factor on Insulin Secretion from Microencapsulated Pancreatic Islets: An In Vitro Study

Cell Transplantation, 2001
Microencapsulation of pancreatic islets represents a potentially effective method to prevent graft rejection in allotransplantation or xenotransplantation without the need of immunosuppression.
Wenjing Wang, Yuanjun Gu, Masaaki Miyamoto, Hiroshi Hori, Natsuki Nagata, A. N. Balamurugan, Maki Touma, Tomonori Sakurai, Kazutomo Inoue M.D., Ph.D.   +8 more
doaj   +1 more source

Dexamethasone during pregnancy impairs maternal pancreatic β-cell renewal during lactation

Endocrine Connections, 2019
Pancreatic islets from pregnant rats develop a transitory increase in the pancreatic β-cell proliferation rate and mass. Increased apoptosis during early lactation contributes to the rapid reversal of those morphological changes.
Caio Jordão Teixeira, Junia Carolina Santos-Silva, Dailson Nogueira de Souza, Alex Rafacho, Gabriel Forato Anhe, Silvana Bordin   +5 more
doaj   +1 more source

Bioprinted 3D Bionic Scaffolds with Pancreatic Islets as a New Therapy for Type 1 Diabetes—Analysis of the Results of Preclinical Studies on a Mouse Model

Journal of Functional Biomaterials, 2023
Recently, tissue engineering, including 3D bioprinting of the pancreas, has acquired clinical significance and has become an outstanding potential method of customized treatment for type 1 diabetes mellitus. The study aimed to evaluate the function of 3D-
Marta Klak, Michał Wszoła, Andrzej Berman, Anna Filip, Anna Kosowska, Joanna Olkowska-Truchanowicz, Michał Rachalewski, Grzegorz Tymicki, Tomasz Bryniarski, Marta Kołodziejska, Tomasz Dobrzański, Dominika Ujazdowska, Jarosław Wejman, Izabela Uhrynowska-Tyszkiewicz, Artur Kamiński   +14 more
doaj   +1 more source

Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model

Scientific Reports, 2017
Human in vitro physiological models studying disease and drug treatment effects are urgently needed as more relevant tools to identify new drug targets and therapies.
S. Bauer, Charlotte Wennberg Huldt, Kajsa P. Kanebratt, Isabell Durieux, Daniela Gunne, S. Andersson, L. Ewart, W. Haynes, I. Maschmeyer, A. Winter, Carina Ämmälä, U. Marx, T. Andersson   +12 more
semanticscholar   +1 more source

SARS-CoV-2 infects human pancreatic β cells and elicits β cell impairment

Cell Metabolism, 2021
Emerging evidence points toward an intricate relationship between the pandemic of coronavirus disease 2019 (COVID-19) and diabetes. While preexisting diabetes is associated with severe COVID-19, it is unclear whether COVID-19 severity is a cause or ...
Chien‐Ting Wu, Peter V. Lidsky, Yinghong Xiao, I. Lee, Ran Cheng, Tsuguhisa Nakayama, Sizun Jiang, J. Demeter, R. Bevacqua, Charles A. Chang, Robert L. Whitener, A. Stalder, Bokai Zhu, Han Chen, Y. Goltsev, A. Tzankov, J. Nayak, G. Nolan, M. Matter, R. Andino, P. Jackson   +20 more
semanticscholar   +1 more source

Influence of macrophages on the insulin-synthesizing system under normal conditions and in alloxan diabetes

Медицинская иммунология, 2023
Insulin-synthesizing cells (ISCs) of pancreatic gland are localized both in its islets, and in exocrine portion, as single cells or cellular agglomerates.
T. S. Bulavintseva, B. G. Yushkov, I. G. Danilova, M. T. Abidov   +3 more
doaj   +1 more source

A human pancreatic ECM hydrogel optimized for 3-D modeling of the islet microenvironment

Scientific Reports, 2022
Extracellular matrix (ECM) plays a multitude of roles, including supporting cells through structural and biochemical interactions. ECM is damaged in the process of isolating human islets for clinical transplantation and basic research.
Daniel M. Tremmel, Sara Dutton Sackett, Austin K. Feeney, Samantha A. Mitchell, Michael D. Schaid, Erzsebet Polyak, Peter J. Chlebeck, Sakar Gupta, Michelle E. Kimple, Luis A. Fernandez, Jon S. Odorico   +10 more
doaj   +1 more source

Comprehensive alpha, beta and delta cell transcriptomes reveal that ghrelin selectively activates delta cells and promotes somatostatin release from pancreatic islets

Molecular Metabolism, 2016
Objective Complex local crosstalk amongst endocrine cells within the islet ensures tight coordination of their endocrine output. This is illustrated by the recent demonstration that the negative feedback control by delta cells within pancreatic islets ...
M. Digruccio, Alex M. Mawla, C. Donaldson, G. Noguchi, J. Vaughan, Christopher Cowing-Zitron, T. van der Meulen, M. Huising   +7 more
semanticscholar   +1 more source