Results 161 to 170 of about 21,240,958 (197)

Global pannexin 1 deletion increases tumor-infiltrating lymphocytes in the BRAF/Pten mouse melanoma model. [PDF]

Mol Oncol
Sanchez-Pupo RE, Finch GA, Johnston DE, Craig H, Abdo R, Barr K, Kerfoot S, Dagnino L, Penuela S.   +8 more
europepmc   +1 more source

N-methyl-D-aspartate receptor activation is downstream coupled to pannexin 1 opening by Src kinase in dorsal horn neurons: an essential link for mechanical hyperalgesia in nerve-injured rats. [PDF]

Pain
Zepeda-Morales K, Bravo D, Aránguiz-Barrera J, Ampuero E, Renard GM, Pelissier T, Hernández A, Retamal JS, Constandil L.   +8 more
europepmc   +1 more source

The ATP-exporting channel Pannexin 1 promotes CD8⁺ T cell effector and memory responses. [PDF]

iScience
Vardam-Kaur T, Banuelos A, Gabaldon-Parish M, Macedo BG, Salgado CL, Wanhainen KM, Zhou MH, van Dijk S, Santiago-Carvalho I, Beniwal AS, Leff CL, Peng C, Tran NL, Jameson SC, Borges da Silva H.   +14 more
europepmc   +1 more source

Activation of Pannexin-1 channels causes cell dysfunction and damage in mesangial cells derived from angiotensin II-exposed mice. [PDF]

Front Cell Dev Biol
Lucero CM, Navarro L, Barros-Osorio C, Cáceres-Conejeros P, Orellana JA, Gómez GI.   +5 more
europepmc   +1 more source

Pannexin 1 Contributes to ATP Release in Airway Epithelia [PDF]

American Journal of Respiratory Cell and Molecular Biology, 2009
Abstract ATP is a paracrine regulator of critical airway epithelial cell functions, but the mechanism of its release is poorly understood. Pannexin (Panx) proteins, related to invertebrate innexins, form channels (called pannexons) that are able to release ATP from several cell types.
, Gerhard Dahl, Nevis Fregien
exaly   +3 more sources

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Pannexin-1 channels in epilepsy

Neuroscience Letters, 2019
Pannexin-1 (Panx1) expression is raised in several animal seizure models and in resected human epileptic brain tissue, suggesting relevance to epilepsy. Multiple factors that are characteristic of seizures are thought to regulate Panx1 channel opening, including elevated levels of extracellular K+.
Mark S, Aquilino, Paige, Whyte-Fagundes, Georg, Zoidl, Peter L, Carlen   +3 more
openaire   +2 more sources

Rho Signaling Regulates Pannexin 1-mediated ATP Release from Airway Epithelia [PDF]

Journal of Biological Chemistry, 2011
ATP released from airway epithelial cells promotes purinergic receptor-regulated mucociliary clearance activities necessary for innate lung defense. Cell swelling-induced membrane stretch/strain is a common stimulus that promotes airway epithelial ATP ...
Dale W Laird, Lucia Seminario-Vidal, Silvia Kreda   +2 more
exaly   +3 more sources

Pannexin 1 Ohnologs in the Teleost Lineage

The Journal of Membrane Biology, 2012
Advances in genomic analysis indicate that the early chordate lineage underwent two whole-genome duplication events in fairly rapid succession around 400-600 million years ago, and that a third duplication event punctuated the radiation of ray-finned fishes (teleosts) around 320-350 million years ago. Connexin ohnologs have been disproportionately well
Stephen R, Bond, Nan, Wang, Luc, Leybaert, Christian C, Naus   +3 more
openaire   +2 more sources

S-Nitrosylation Inhibits Pannexin 1 Channel Function [PDF]

Journal of Biological Chemistry, 2012
S-nitrosylation is a post-translational modification on cysteine(s) that can regulate protein function, and pannexin 1 (Panx1) channels are present in the vasculature, a tissue rich in nitric oxide (NO) species. Therefore, we investigated whether Panx1 can be S-nitrosylated and whether this modification can affect channel activity.
Norbert Leitinger, Dale W Laird, Marie Billaud   +2 more
exaly   +3 more sources

Regulation of Pannexin-1 channel activity

Biochemical Society Transactions, 2015
Pannexin-1 (Panx1) forms anion-selective channels with a permeability up to 1 kDa and represents a pathway for the release of cytosolic ATP. Several structurally similar connexin (Cx) proteins have been identified in platelets and shown to play roles in haemostasis and thrombosis.
Kirk A, Taylor, Joy R, Wright, Martyn P, Mahaut-Smith   +2 more
openaire   +2 more sources