Results 171 to 180 of about 21,240,958 (197)

Non-junction functions of pannexin-1 channels

Trends in Neurosciences, 2010
Pannexins are large-pore ion channels with broad expression in the central nervous system (CNS). The channels function by releasing large signaling molecules, such ATP and arachidonic acid derivatives, from neurons and possibly astrocytes. They might also contribute to novel forms of non-synaptic communication in the CNS, thereby affecting synaptic ...
Brian A, MacVicar, Roger J, Thompson
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Channel activity of recombinant pannexin 1

Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology, 2011
Mammalian taste cells of the type II release ATP, an afferent neurotransmitter, by employing unselective ATP-permeable ion channels. The molecular identity of these channels is not known with confidence, although evidence implicates certain channel proteins from the connexin and pannexin families as most likely candidates.
R. A. Romanov, M. F. Bystrova, O. A. Rogachevskaya, S. S. Kolesnikov   +3 more
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Pannexin 1

2022
Die hypoxische pulmonale Vasokonstriktion ist ein durch alveoläre Hypoxie ausgelöster aktiver physiologischer Mechanismus, der den pulmonalen Blutfluss aus sauerstoffärmeren Bereichen der Lunge in besser ventilierte Regionen umleitet, um die Sauerstoffversorgung zu optimieren. Die molekularen Signalwege, welche die hypoxische pulmonale Vasokonstriktion
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Pannexin-1 Channel Regulates ATP Release in Epilepsy

Neurochemical Research, 2020
With the deepening of research on epilepsy in recent decades, great progress has been made in the diagnosis and treatment of the disease. However, the clinical outcome remains unsatisfactory due to the confounding symptoms and complications, as well as complex intrinsic pathogenesis. A better understanding of the pathogenesis of epilepsy should be able
Yisi, Shan, Yaohui, Ni, Zhiwei, Gao
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A pannexin 1 channelopathy causes human oocyte death

Science Translational Medicine, 2019
Inherited dominant mutations in PANX1 cause female infertility characterized by oocyte death.
Qing Sang, Zhihua Zhang, Juanzi Shi, Xiaoxi Sun, Bin Li, Zheng Yan, Songguo Xue, Ai Ai, Qifeng Lyu, Wei Li, Jilin Zhang, Ling Wu, Xiaoyan Mao, Biaobang Chen, Jian Mu, Qiaoli Li, Jing Du, Qiang Sun, Li Jin, Lin He, Shujia Zhu, Yanping Kuang, Lei Wang   +22 more
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ATP stimulates pannexin 1 internalization to endosomal compartments

Biochemical Journal, 2015
The ubiquitous pannexin 1 (Panx1) ion- and metabolite-permeable channel mediates the release of ATP, a potent signalling molecule. In the present study, we provide striking evidence that ATP, in turn, stimulates internalization of Panx1 to intracellular membranes. These findings hold important implications for understanding the regulation of Panx1 when
Andrew K J, Boyce, Michelle S, Kim, Leigh E, Wicki-Stordeur, Leigh Anne, Swayne   +3 more
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Effect of pannexin-1 on the release of glutamate and cytokines in astrocytes

Journal of Clinical Neuroscience, 2016
We investigated the effect of pannexin-1 (PANX-1) on the release of glutamate and cytokines in U87 human malignant glioma (U87-MG) cells using small interfering RNA (siRNA) transfection and adenosine triphosphate/lipopolysaccharide treatment. PANX-1 is a new family member of the gap junction proteins, and is permeable to ions, metabolic molecules ...
Li, Wei, Hanmiao, Sheng, Long, Chen, Bin, Hao, Xiaohong, Shi, Yinghui, Chen   +5 more
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Editorial: Pannexin-1—the hidden gatekeeper for HIV-1

Journal of Leukocyte Biology, 2013
Discussion on the hemichannel PANX1 and associated signaling molecules as new targets for the development of anti-HIV therapeutic strategies.
Audrey, Paoletti, Syed Qasim, Raza, Laurent, Voisin, Frédéric, Law, Marina, Caillet, Isabelle, Martins, Eric, Deutsch, Jean-Luc, Perfettini   +7 more
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Novel Pannexin 1 isoform is increased in cancer

ABSTRACT Pannexin 1 (PANX1) is upregulated in many cancers, where its channel activity and signalling promote tumorigenic properties. Here, we report that potential internal translation start sites exist in mouse and human PANX1 which have implications in trafficking and protein interaction.
Brooke L. O’Donnell, Dan Stefan, Yu-Hsin Chiu, Michael J. Zeitz, Justin Tang, Danielle Johnston, Stephanie E. Leighton, Carlijn Van Kessel, Kevin Barr, Laszlo Gyenis, Taylor J. Freeman, John J. Kelly, Samar Sayedyahossein, Brant E. Isakson, David W. Litchfield, Kathryn Roth, James W. Smyth, Matthew Hebb, John Ronald, Douglas A. Bayliss, Silvia Penuela   +20 more
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Neurodegeneration and Neuroinflammation: The Role of Pannexin 1

Neurochemical Journal, 2023
M. D. Galkov, A. M. Surin, O. Yu. Lisina, L. R. Gorbacheva   +3 more
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