Results 141 to 150 of about 5,309 (159)

Diverse calcium signaling profiles regulate migratory behavior in avascular wound healing and aberrant signal hierarchy occurs early in diabetes.

Am J Physiol Cell Physiol
Segars KL, Azzari N, Cole M, Kushimi L, Rapaka S, Rich CB, Trinkaus-Randall V.   +6 more
europepmc   +1 more source

Connexins, Innexins, and Pannexins

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Pannexin expression in the cerebellum

The Cerebellum, 2006
Pannexin1 and pannexin2 are members of the pannexin gene family which are widely expressed in the central nervous system. Here we present an overview of pannexin expression and distribution in the mouse cerebellum. Pannexin1 and pannexin2 are expressed in the Purkinje cells and in some cells of the granule cell layer. Pannexin2 is also expressed in the
Arundhati, Ray, Georg, Zoidl, Petra, Wahle, Rolf, Dermietzel   +3 more
openaire   +2 more sources

Pannexin-1 channels in epilepsy

Neuroscience Letters, 2019
Pannexin-1 (Panx1) expression is raised in several animal seizure models and in resected human epileptic brain tissue, suggesting relevance to epilepsy. Multiple factors that are characteristic of seizures are thought to regulate Panx1 channel opening, including elevated levels of extracellular K+.
Mark S, Aquilino, Paige, Whyte-Fagundes, Georg, Zoidl, Peter L, Carlen   +3 more
openaire   +2 more sources

Regulation of Pannexin-1 channel activity

Biochemical Society Transactions, 2015
Pannexin-1 (Panx1) forms anion-selective channels with a permeability up to 1 kDa and represents a pathway for the release of cytosolic ATP. Several structurally similar connexin (Cx) proteins have been identified in platelets and shown to play roles in haemostasis and thrombosis.
Kirk A, Taylor, Joy R, Wright, Martyn P, Mahaut-Smith   +2 more
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Ubiquitination and Proteasomal Regulation of Pannexin 1 and Pannexin 3

2020
Pannexin 1 (PANX1) and Pannexin 3 (PANX3) are single-membrane channel glycoproteins that allow for communication between the cell and its environment to regulate cellular differentiation, proliferation, and apoptosis. Their expression is regulated through post-translational modifications, however, their regulation by ubiquitination and the ubiquitin ...
openaire   +2 more sources

Intrapore lipids hydrophobically gate pannexin-1 channels

Science Signaling, 2022
Large-pore channels such as pannexin-1 (PANX1) typically lack pore-lining constriction points, leaving only speculations on how these channels functionally “close.” In this issue of Science Signaling , Kuzuya et al .
Connor L. Anderson, Roger J. Thompson
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Connexins and pannexins in Alzheimer’s disease

Neuroscience Letters, 2019
By 2040 neurodegenerative diseases will become the world's second leading cause of death after cardiovascular disease (WHO). Major efforts are required to elucidate the underlying molecular and cellular mechanisms of neurodegenerative diseases. Connexin and pannexin membrane channel proteins are conduits through which neuronal, glial, and vascular ...
Christian, Giaume, Juan C, Sáez, Weihong, Song, Luc, Leybaert, Christian C, Naus   +4 more
openaire   +3 more sources