Results 101 to 110 of about 27,134,532 (169)

Pannexin 1 Regulates Bidirectional Hippocampal Synaptic Plasticity in Adult Mice

Frontiers in Cellular Neuroscience, 2014
The threshold for bidirectional modification of synaptic plasticity is known to be controlled by several factors, including the balance between protein phosphorylation and dephosphorylation, postsynaptic free Ca2+ concentration and NMDA receptor (NMDAR ...
Alvaro O. Ardiles, Carolina eFlores-Muñoz, Gabriela eToro-Ayala, Ana María Cárdenas, Adrian G Palacios, Pablo eMuñoz, Pablo eMuñoz, Marco eFuenzalida, Juan C Saez, Juan C Saez, Agustin D Martinez   +10 more
doaj   +1 more source

The P2X7 Receptor and Its Relation to Neglected Tropical Diseases: Focusing on Chagas Disease

Journal of Tropical Medicine, Volume 2026, Issue 1, 2026.
Chagas disease, caused by Trypanosoma cruzi, is a neglected tropical disease (NTD) that can lead to severe cardiac complications, including chronic Chagas cardiomyopathy. While NTDs are caused by a variety of pathogens—such as protozoa, bacteria, viruses, and helminths, Chagas disease remains underexplored, particularly regarding host immune responses.
Caroline de Souza Ferreira Pereira, Robson Xavier Faria, Wei Wang   +2 more
wiley   +1 more source

Cuproptosis at the Crossroads of Tumor Microenvironment Inflammation and Metabolic Rewiring Mechanisms and Therapeutic Opportunities

Mediators of Inflammation, Volume 2026, Issue 1, 2026.
Metabolic reorganization and chronic inflammation are dynamic and diverse events in the tumor microenvironment (TME) that cause tumor propagation, spreading, and resistance to treatment. However, copper‐induced cell death (cuproptosis), which is a newly discovered form of regulated cell death (RCD) induced by high intracellular copper ions and is a ...
Yan Wang, Yunfei Zhu, Yanxin Wang, Yutong Liu, Pengfei Wang, Mingkun Yu, Hengrui Liu   +6 more
wiley   +1 more source

Mechanism of GSDMD in the Pathogenesis of Pasteurella multocida PmCQ2

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Pasteurella multocida serotype A (PmCQ2), a Gram‐negative zoonotic pathogen, causes severe respiratory disease in a variety of domestic and wild animals, leading to high morbidity and mortality and substantial agricultural economic losses. Pyroptosis, a gasdermin‐mediated programmed cell death mechanism, facilitates pathogen clearance but exacerbates ...
Qingqing Yang, Wei Wang, Xin Shen, Yi Lu, Jiajia Zheng, Jinrong Ran, Xuefeng Cao, Rendong Fang, Zongfu Wu   +8 more
wiley   +1 more source

Genome‐Wide Protein Interaction Analysis in Parasitic Gyrodactylus Flatworms–Fish Hosts System and Drug Target Identification

Advanced Science, Volume 12, Issue 45, December 4, 2025.
Genomic data offer a powerful tool for studying the molecular interactions between parasites and their hosts, but they remain scarce for parasitic monogenean flatworms. This study presents the first high‐quality phased genome assembly for monogeneans (Gyrodactylus kobayashii), and uses it to predict key interacting proteins between monogenean parasite ‐
Dong Zhang, Jie‐Mei Zhao, Chuan‐Yu Xiang, Yi‐Wen Ma, Hong‐Peng Lei, Yu‐Ying Shi, Shun Zhou, Xiaofei Zeng, Jinsong Chen, Fei Liu, Benhe Zeng, Rui Song, Ye Hu, Feng Zhang, Xiang Liu, Wen‐Xiang Li, Gui‐Tang Wang, Ivan Jakovlić   +17 more
wiley   +1 more source

Baicalin inhibited PANX-1/P2Y6 signaling pathway activation in porcine aortic vascular endothelial cells infected by Glaesserella parasuis

Heliyon
Glaesserella parasuis can induce endothelial barrier damage in piglets, although the mechanism by which this pathogen triggers inflammatory damage remains unclear. Baicalin possesses anti-inflammatory and anti-oxidant activities.
Shulin Fu, Xinyue Tian, Chun Peng, Dan Zhang, Linglu Zhou, Yuzhen Yuan, Jing He, Ling Guo, Yinsheng Qiu, Chun Ye, Yu Liu, Bingbing Zong   +11 more
doaj   +1 more source

Impact of Endothelial Diversity and Dysfunction on Cardiovascular Disease

Comprehensive Physiology, Volume 15, Issue 6, December 2025.
The vascular endothelium is highly diverse, regulating permeability, vascular tone, repair, and inter‐organ communication. Endothelial heterogeneity supports tissue‐specific needs, but dysfunction drives cardiovascular disease. Transcriptomics, in vitro models, and redox signaling studies reveal therapeutic targets for precision treatment of ...
Anna E. Williams, Luke S. Dunaway, Zuzanna J. Juśkiewicz, Wyatt J. Schug, Miriam M. Cortese‐Krott, Michael Koval, Brant E. Isakson   +6 more
wiley   +1 more source

ATP-release pannexin channels are gated by lysophospholipids

eLife
In addition to its role as cellular energy currency, adenosine triphosphate (ATP) serves as an extracellular messenger that mediates diverse cell-to-cell communication.
Erik Henze, Russell N Burkhardt, Bennett William Fox, Tyler J Schwertfeger, Eric Gelsleichter, Kevin Michalski, Lydia Kramer, Margret Lenfest, Jordyn M Boesch, Hening Lin, Frank C Schroeder, Toshimitsu Kawate   +11 more
doaj   +1 more source

The two faces of pannexins: new roles in inflammation and repair

Journal of Inflammation Research, 2018
Helen P Makarenkova,1 Sameer B Shah,2,3 Valery I Shestopalov4–6 1Department of Molecular Medicine, Scripps Research Institute, 2Departments of Orthopaedic Surgery and Bioengineering, University of California, 3Research Division, Veterans Affairs ...
Makarenkova HP, Shah SB, Shestopalov VI
doaj  

Probenecid, a gout remedy, inhibits pannexin 1 channels

American Journal of Physiology-Cell Physiology, 2008
Probenecid is a well-established drug for the treatment of gout and is thought to act on an organic anion transporter, thereby affecting uric acid excretion in the kidney by blocking urate reuptake. Probenecid also has been shown to affect ATP release, leading to the suggestion that ATP release involves an organic anion transporter.
William, Silverman, Silviu, Locovei, Gerhard, Dahl   +2 more
openaire   +3 more sources