Results 141 to 150 of about 27,134,532 (169)

Pannexin-1 channels in epilepsy

Neuroscience Letters, 2019
Pannexin-1 (Panx1) expression is raised in several animal seizure models and in resected human epileptic brain tissue, suggesting relevance to epilepsy. Multiple factors that are characteristic of seizures are thought to regulate Panx1 channel opening, including elevated levels of extracellular K+.
Mark S, Aquilino, Paige, Whyte-Fagundes, Georg, Zoidl, Peter L, Carlen   +3 more
openaire   +2 more sources

Regulation of Pannexin-1 channel activity

Biochemical Society Transactions, 2015
Pannexin-1 (Panx1) forms anion-selective channels with a permeability up to 1 kDa and represents a pathway for the release of cytosolic ATP. Several structurally similar connexin (Cx) proteins have been identified in platelets and shown to play roles in haemostasis and thrombosis.
Kirk A, Taylor, Joy R, Wright, Martyn P, Mahaut-Smith   +2 more
openaire   +2 more sources

Divergent sex-specific pannexin-1 mechanisms in microglia and T cells underlie neuropathic pain.

Neuron
Chronic pain is a leading cause of disability, affecting more women than men. Different immune cells contribute to this sexual divergence, but the mechanisms, especially in females, are not well defined.
C. Fan, Brendan B. McAllister, Sierra Stokes-Heck, Erika K. Harding, Aliny Pereira de Vasconcelos, Laura K. Mah, L. V. Lima, Nynke J. van den Hoogen, S. Rosen, B. Ham, Zizhen Zhang, Hongrui Liu, F. Zemp, R. Burkhard, M. Geuking, Douglas J. Mahoney, Gerald W. Zamponi, J. Mogil, S. Ousman, Tuan Trang   +19 more
semanticscholar   +1 more source

Pannexin 1 forms an anion-selective channel

Pflügers Archiv - European Journal of Physiology, 2012
Pannexin 1 (Panx1) is expressed in various mammalian tissues including the brain and immune cells. Here, we present evidence that Panx1 when expressed in mammalian cells, forms anion-selective channels, with a rank order of permeabilities: NO (3) (-)> I(-) > Br (-)> Cl (-) > F (-)>> aspartate (-)≈ glutamate (-)≈ gluconate(-).
Ma, Weihong, Compan, Vincent, Zheng, Wenxuan, Martin, Elizabeth, North, R. Alan, Verkhratsky, Alexei, Surprenant, Annmarie   +6 more
openaire   +3 more sources

Pannexin‐1 Aggravates Inflammatory Bowel Disease via Unbalancing Macrophage Polarisation and Triggering Ferroptosis in Mice

Immunology
Inflammatory bowel disease (IBD) is characterised by chronic inflammation in the gastrointestinal tract resulting from dysregulated immune responses to gut microflora. Intestinal macrophages play important roles in the pathogenesis of IBD.
Qingfan Zheng, Yunfeng Qiu
semanticscholar   +1 more source

Non-junction functions of pannexin-1 channels

Trends in Neurosciences, 2010
Pannexins are large-pore ion channels with broad expression in the central nervous system (CNS). The channels function by releasing large signaling molecules, such ATP and arachidonic acid derivatives, from neurons and possibly astrocytes. They might also contribute to novel forms of non-synaptic communication in the CNS, thereby affecting synaptic ...
Brian A, MacVicar, Roger J, Thompson
openaire   +2 more sources

Pannexin 1 Ohnologs in the Teleost Lineage

The Journal of Membrane Biology, 2012
Advances in genomic analysis indicate that the early chordate lineage underwent two whole-genome duplication events in fairly rapid succession around 400-600 million years ago, and that a third duplication event punctuated the radiation of ray-finned fishes (teleosts) around 320-350 million years ago. Connexin ohnologs have been disproportionately well
Stephen R, Bond, Nan, Wang, Luc, Leybaert, Christian C, Naus   +3 more
openaire   +2 more sources

Ubiquitination and Proteasomal Regulation of Pannexin 1 and Pannexin 3

2020
Pannexin 1 (PANX1) and Pannexin 3 (PANX3) are single-membrane channel glycoproteins that allow for communication between the cell and its environment to regulate cellular differentiation, proliferation, and apoptosis. Their expression is regulated through post-translational modifications, however, their regulation by ubiquitination and the ubiquitin ...
openaire   +2 more sources

Pannexin-1 Channel Regulates ATP Release in Epilepsy

Neurochemical Research, 2020
With the deepening of research on epilepsy in recent decades, great progress has been made in the diagnosis and treatment of the disease. However, the clinical outcome remains unsatisfactory due to the confounding symptoms and complications, as well as complex intrinsic pathogenesis. A better understanding of the pathogenesis of epilepsy should be able
Yisi, Shan, Yaohui, Ni, Zhiwei, Gao
openaire   +2 more sources

Pannexin 1 channels: A Bridge Between Synaptic Plasticity and Learning and Memory Processes.

Neuroscience and Biobehavioral Reviews
The Pannexin 1 channel is a membrane protein widely expressed in various vertebrate cell types, including microglia, astrocytes, and neurons within the central nervous system.
Javiera Illanes-González, Carolina Flores-Muñoz, Nathalia Vitureira, Andrés Ardiles   +3 more
semanticscholar   +1 more source