Results 151 to 160 of about 27,134,532 (169)

Low levels of pannexin‐1 in Behçet’s syndrome

International Journal of Rheumatic Diseases, 2019
AbstractObjectiveBehçet's syndrome (BS) is a chronic, multisystemic and inflammatory syndrome. In our study, we aimed to compare the initiator, effector and inflammatory caspases and pannexin channel protein, which is thought to have an activity in inflammation, in the inflammatory process of BS, with healthy subjects, to investigate their level in ...
Ali Şahin, Abdullah İlhan, Mehmet Emin Derin, Halef Okan Doğan, Mehtap Şahin   +4 more
openaire   +4 more sources

SIL14, a New Quinoline-Based Pannexin-1 Channel Blocker Attenuates Development of Renal Cysts

Physiology
Background: Polycystic kidney diseases (PKD) are a group of inherited nephropathies marked with the formation of fluid-filled cysts along the nephron.
Veniamin Ivanov, T. Liao, Gabriella Guerrini, Letizia Crocetti, Pablo A. Ortiz, Tengis S. Pavlov   +5 more
semanticscholar   +1 more source

Editorial: Pannexin-1—the hidden gatekeeper for HIV-1

Journal of Leukocyte Biology, 2013
Discussion on the hemichannel PANX1 and associated signaling molecules as new targets for the development of anti-HIV therapeutic strategies.
Audrey, Paoletti, Syed Qasim, Raza, Laurent, Voisin, Frédéric, Law, Marina, Caillet, Isabelle, Martins, Eric, Deutsch, Jean-Luc, Perfettini   +7 more
openaire   +2 more sources

Human Platelets Express Functional Pannexin-1

Blood, 2011
Abstract Abstract 1132 The protein family of pannexins (Panx) contains three members (Panx1, Panx2 and Panx3) that are highly evolutionarily conserved from worms to mammals, and that form hemichannels involved in the transport of ions like Ca2+ and small molecules such as ATP into and out of cells.
Jaime Pereira, Kenji F Shoji, Anibal A Vargas, Juan A Orellana, Claudia G Saez, Karla Pereira, Cathy Paddock, Christopher Kuckleburg, Peter J. Newman, Diego Mezzano, Juan C Sáez   +10 more
openaire   +1 more source

Novel Pannexin 1 isoform is increased in cancer

bioRxiv
ABSTRACTPannexin 1 (PANX1) is upregulated in many cancers, where its channel activity and signalling promote tumorigenic properties. Here, we report that potential internal translation start sites exist in mouse and human PANX1 which have implications in trafficking and protein interaction.
Brooke L. O’Donnell, Dan Stefan, Yu-Hsin Chiu, Michael J. Zeitz, Justin Tang, Danielle Johnston, Stephanie E. Leighton, Carlijn Van Kessel, Kevin J. Barr, L. Gyenis, Taylor J Freeman, John J. Kelly, Samar Sayedyahossein, BE Isakson, D. Litchfield, Kathryn Roth, James W. Smyth, M. Hebb, John Ronald, Douglas A Bayliss, S. Penuela   +20 more
semanticscholar   +3 more sources

Recent advances in the structure and activation mechanisms of metabolite-releasing Pannexin 1 channels.

Biochemical Society Transactions, 2023
Pannexin 1 (PANX1) is a widely expressed large-pore ion channel located in the plasma membrane of almost all vertebrate cells. It possesses a unique ability to act as a conduit for both inorganic ions (e.g.
Yi-Ling Wu, A. Yang, Y. Chiu
semanticscholar   +1 more source

Channel activity of recombinant pannexin 1

Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology, 2011
Mammalian taste cells of the type II release ATP, an afferent neurotransmitter, by employing unselective ATP-permeable ion channels. The molecular identity of these channels is not known with confidence, although evidence implicates certain channel proteins from the connexin and pannexin families as most likely candidates.
R. A. Romanov, M. F. Bystrova, O. A. Rogachevskaya, S. S. Kolesnikov   +3 more
openaire   +1 more source

Pannexin 1

2022
Die hypoxische pulmonale Vasokonstriktion ist ein durch alveoläre Hypoxie ausgelöster aktiver physiologischer Mechanismus, der den pulmonalen Blutfluss aus sauerstoffärmeren Bereichen der Lunge in besser ventilierte Regionen umleitet, um die Sauerstoffversorgung zu optimieren. Die molekularen Signalwege, welche die hypoxische pulmonale Vasokonstriktion
openaire   +1 more source

A pannexin 1 channelopathy causes human oocyte death

Science Translational Medicine, 2019
Inherited dominant mutations in PANX1 cause female infertility characterized by oocyte death.
Qing Sang, Zhihua Zhang, Juanzi Shi, Xiaoxi Sun, Bin Li, Zheng Yan, Songguo Xue, Ai Ai, Qifeng Lyu, Wei Li, Jilin Zhang, Ling Wu, Xiaoyan Mao, Biaobang Chen, Jian Mu, Qiaoli Li, Jing Du, Qiang Sun, Li Jin, Lin He, Shujia Zhu, Yanping Kuang, Lei Wang   +22 more
openaire   +2 more sources

Pannexin-1 expression in tumor cells correlates with colon cancer progression and survival.

Life Science
AIMS Pannexin-1 (PANX1) is a hemichannel that releases ATP upon opening, initiating inflammation, cell proliferation, and migration. However, the role of PANX1 channels in colon cancer remains poorly understood, thus constituting the focus of this study.
Aaron Fierro-Arenas, G. Landskron, Ilan Camhi-Vainroj, Benjamín Basterrechea, Daniela Parada-Venegas, L. Lobos-González, Karen Dubois-Camacho, Catalina Araneda, Camila Romero, Antonia Domínguez, Gonzalo Vásquez, Francisco López-K, K. Álvarez, Carlos M. Gonzalez, Carolina H. Ribeiro, Elisa Balboa, E. Eugenin, Marcela A. Hermoso, Marjorie De la Fuente López   +18 more
semanticscholar   +1 more source