Results 141 to 150 of about 1,521 (154)
Some of the next articles are maybe not open access.
Pannexin-1 channels in epilepsy
Neuroscience Letters, 2019Pannexin-1 (Panx1) expression is raised in several animal seizure models and in resected human epileptic brain tissue, suggesting relevance to epilepsy. Multiple factors that are characteristic of seizures are thought to regulate Panx1 channel opening, including elevated levels of extracellular K+.
Mark S, Aquilino +3 more
openaire +2 more sources
Regulation of Pannexin-1 channel activity
Biochemical Society Transactions, 2015Pannexin-1 (Panx1) forms anion-selective channels with a permeability up to 1 kDa and represents a pathway for the release of cytosolic ATP. Several structurally similar connexin (Cx) proteins have been identified in platelets and shown to play roles in haemostasis and thrombosis.
Kirk A, Taylor +2 more
openaire +2 more sources
Ubiquitination and Proteasomal Regulation of Pannexin 1 and Pannexin 3
2020Pannexin 1 (PANX1) and Pannexin 3 (PANX3) are single-membrane channel glycoproteins that allow for communication between the cell and its environment to regulate cellular differentiation, proliferation, and apoptosis. Their expression is regulated through post-translational modifications, however, their regulation by ubiquitination and the ubiquitin ...
openaire +2 more sources
Intrapore lipids hydrophobically gate pannexin-1 channels
Science Signaling, 2022Large-pore channels such as pannexin-1 (PANX1) typically lack pore-lining constriction points, leaving only speculations on how these channels functionally “close.” In this issue of Science Signaling , Kuzuya et al .
Connor L. Anderson, Roger J. Thompson
openaire +2 more sources
Connexins and pannexins in Alzheimer’s disease
Neuroscience Letters, 2019By 2040 neurodegenerative diseases will become the world's second leading cause of death after cardiovascular disease (WHO). Major efforts are required to elucidate the underlying molecular and cellular mechanisms of neurodegenerative diseases. Connexin and pannexin membrane channel proteins are conduits through which neuronal, glial, and vascular ...
Christian, Giaume +4 more
openaire +3 more sources
2009
Pannexins are a family of three vertebrate proteins that have moderate sequence homology with the innexin proteins, which compose gap junction channels in protostomes, including most invertebrates. However, it appears that in contrast to innexins, pannexins do not have the ability to form gap junction channels.
Gerhard Dahl, Andrew L. Harris
openaire +1 more source
Pannexins are a family of three vertebrate proteins that have moderate sequence homology with the innexin proteins, which compose gap junction channels in protostomes, including most invertebrates. However, it appears that in contrast to innexins, pannexins do not have the ability to form gap junction channels.
Gerhard Dahl, Andrew L. Harris
openaire +1 more source
2022
Die hypoxische pulmonale Vasokonstriktion ist ein durch alveoläre Hypoxie ausgelöster aktiver physiologischer Mechanismus, der den pulmonalen Blutfluss aus sauerstoffärmeren Bereichen der Lunge in besser ventilierte Regionen umleitet, um die Sauerstoffversorgung zu optimieren. Die molekularen Signalwege, welche die hypoxische pulmonale Vasokonstriktion
openaire +1 more source
Die hypoxische pulmonale Vasokonstriktion ist ein durch alveoläre Hypoxie ausgelöster aktiver physiologischer Mechanismus, der den pulmonalen Blutfluss aus sauerstoffärmeren Bereichen der Lunge in besser ventilierte Regionen umleitet, um die Sauerstoffversorgung zu optimieren. Die molekularen Signalwege, welche die hypoxische pulmonale Vasokonstriktion
openaire +1 more source
Pannexins and gap junction protein diversity
Cellular and Molecular Life Sciences, 2007Gap junctions (GJs) are composed of proteins that form a channel connecting the cytoplasm of adjacent cells. Connexins were initially considered to be the only proteins capable of GJ formation. Another family of GJ proteins (innexins) were first found in invertebrates and were proposed to be renamed pannexins after their orthologs were discovered in ...
V I, Shestopalov, Y, Panchin
openaire +2 more sources
Pannexin Channels: The Emerging Therapeutic Targets
Current Drug Targets, 2014Intercellular communication plays a pivotal role in various physiological functions. This is mainly done through gap junctions and trans-membrane channels. The structural proteins forming these channels are different in vertebrates and invertebrates namely connexins and innexins respectively.
Misbahuddin, Mohammad, Hamed Said, Habib
openaire +2 more sources