Sigma‐1 Receptor‐Targeting Compounds Show Antiviral Activity Across Multiple Coronavirus Models
ABSTRACT Over the past two decades, coronaviruses have caused three major public health crises, including the epidemics of SARS‐CoV, MERS‐CoV, and SARS‐CoV‐2. Following the outbreak of SARS‐CoV‐2, several antiviral drugs have been approved for the treatment of COVID‐19.
Cuiling Zhang +9 more
wiley +1 more source
The Preparation of Hypoallergenic Goat Milk Protein Hydrolysates via Targeted Hydrolysis of Cross-Reactive Linear Epitopes Between Cow and Goat Milk. [PDF]
Wang F, Zhao W, Cong Y.
europepmc +1 more source
ABSTRACT The rise of multidrug‐resistant (MDR) pathogens presents a major challenge to food safety, particularly in preservation approaches. Lactic acid bacteria (LAB) gain probiotic recognition by effectively controlling MDR pathogens using antimicrobial substances (AMSs) and bacteriocin‐like inhibitory substances (BLISs).
Md. Moklesur Rahman +5 more
wiley +1 more source
A novel mouse model of chronic Pseudomonas aeruginosa infection inducing bronchiectasis-like phenotype. [PDF]
Yang H +11 more
europepmc +1 more source
Carbon quantum dots (CDs) have emerged as versatile nanoplatforms for combating biofilm‐associated infections through multiple mechanisms, including EPS disruption, membrane damage, ROS generation, and quorum sensing inhibition. This review highlights how CD physicochemical properties and surface engineering strategies influence antibiofilm activity ...
Hadeer M. Bedair +5 more
wiley +1 more source
Improving tenderness and quality of camel meat through ultrasound and papain treatment: Insights from structural and proteomics analysis. [PDF]
Ming L +5 more
europepmc +1 more source
RheoScale 2.0: Revealing the hidden roles of protein positions via substitution patterns
Abstract A central challenge in molecular biology is understanding how amino acid substitutions modulate various features of protein function and stability. To illuminate the complexities of this relationship, high‐throughput (HTP) assays are increasingly used to assess site‐saturating mutagenesis libraries.
David H. Liu +4 more
wiley +1 more source
Chitosan/reduced graphene oxide/papain nanocomposite: a bioactive platform for skincare and biomedical applications. [PDF]
Elhami N, Pazhang M.
europepmc +1 more source
Coumarin‐Benzimidazole Hybrids as Multitarget Scaffolds for Antileishmanial Drug Discovery
Coumarin‐benzimidazole hybrids emerge as promising antileishmanial agents through virtual screening against essential Leishmania enzymes, Cathepsin B (CatB), and N‐myristoyltransferase (NMT). Molecular docking and dynamics simulations reveal highly stable target interactions that surpass the reference drug miltefosine (MTF).
Fernanda Melo Jucá +4 more
wiley +1 more source
RETRACTED: Osman et al. Foliar Spray with Pepsin-and Papain-Whey Protein Hydrolysates Promotes the Productivity of Pea Plants Cultivated in Clay Loam Soil. <i>Molecules</i> 2021, <i>26</i>, 2805. [PDF]
Osman A +3 more
europepmc +1 more source

