Results 171 to 180 of about 16,692 (213)
Some of the next articles are maybe not open access.
Current Pharmaceutical Design, 2018
Background: Paraoxonase (PON) is a family of calcium-dependent hydrolases, which is related to many diseases. Elucidation of PON physiological roles, active center and all applications in medical fields are dependent on its substrates. Objective: The reports about PON substrates scattered in a long span of period are collected to afford clue for ...
Xiaojing, Mu +5 more
openaire +2 more sources
Background: Paraoxonase (PON) is a family of calcium-dependent hydrolases, which is related to many diseases. Elucidation of PON physiological roles, active center and all applications in medical fields are dependent on its substrates. Objective: The reports about PON substrates scattered in a long span of period are collected to afford clue for ...
Xiaojing, Mu +5 more
openaire +2 more sources
Annals of Human Genetics, 1981
SUMMARYDanish family material comprising 1664 unrelated individuals (parents) and 3169 children, as well as 699 grandparents of the same families, were examined for paraoxonase activity. A micro‐autoanalyser method, comprising a primary testing in tris buffer at pH 7‐5 and, in the case of primarily intermediate individuals, a secondary testing at pH 10,
H, Eiberg, J, Mohr
openaire +2 more sources
SUMMARYDanish family material comprising 1664 unrelated individuals (parents) and 3169 children, as well as 699 grandparents of the same families, were examined for paraoxonase activity. A micro‐autoanalyser method, comprising a primary testing in tris buffer at pH 7‐5 and, in the case of primarily intermediate individuals, a secondary testing at pH 10,
H, Eiberg, J, Mohr
openaire +2 more sources
Paraoxonase protects against chlorpyrifos toxicity in mice
Toxicology Letters, 1995 Paraoxonase can hydrolyze paraoxon (PO), chlorpyrifos-oxon (CPO) and other organophosphates. Previous studies have indicated that the levels of serum paraoxonase can influence the toxicity of PO and CPO.
Lucio G. Costa +2 more
exaly +1 more source
General Pharmacology: The Vascular System, 1998
1. Human serum paraoxonase (PON1) is a Ca2+-dependent 45-kDa glycoprotein that is associated with high density lipoprotein (HDL). 2. PON1 hydrolyzes organophosphate (OP) insecticides and nerve gases and is responsible for determining the selective toxicity of these compounds in mammals. 3.
B, Mackness +2 more
openaire +2 more sources
1. Human serum paraoxonase (PON1) is a Ca2+-dependent 45-kDa glycoprotein that is associated with high density lipoprotein (HDL). 2. PON1 hydrolyzes organophosphate (OP) insecticides and nerve gases and is responsible for determining the selective toxicity of these compounds in mammals. 3.
B, Mackness +2 more
openaire +2 more sources
Paraoxonase and arylesterase activities in coronary artery disease
European Journal of Clinical Investigation, 2006 Background: Paraoxonase-1 is an enzyme with three activities which are inversely related to cardiovascular diseases. Accordingly, the aim of the study was to investigate the paraoxonase, arylesterase activities and oxidative/anti-oxidative status in ...
Recep Demirbag +2 more
exaly +2 more sources
Paraoxonase activity and dementia
Journal of the Neurological Sciences, 2009Paraoxonase activity, homocysteine level and lipids were determined in 120 patients with dementia (51 with Alzheimer disease, 28 with dementia of vascular origin, 41 with mixed dementia), 45 with mild cognitive impairment and in 61 age and sex matched controls without dementia.
Hanna, Wehr +6 more
openaire +2 more sources
The role of paraoxonase in cancer
Seminars in Cancer Biology, 2019The paraoxonase (PON) gene family includes three proteins, PON1, PON2 and PON3. PON1 and PON3 are both associated with high-density lipoprotein (HDL) particles and exert anti-oxidant and anti-inflammatory properties. PON2 and PON3 are intracellular enzymes which modulate mitochondrial superoxide anion production and endoplasmic reticulum (ER) stress ...
Tiziana, Bacchetti +2 more
openaire +2 more sources
2017
The paraoxonases (PONs) are a three-gene family which includes PON1, PON2, and PON3. PON1 and PON3 are synthesized primarily in the liver and a portion is secreted in the plasma, where they are associated with high-density lipoproteins (HDLs), while PON2 is an intracellular enzyme, expressed in most tissues and organs, including the brain.
Costa, Lucio G. +4 more
openaire +3 more sources
The paraoxonases (PONs) are a three-gene family which includes PON1, PON2, and PON3. PON1 and PON3 are synthesized primarily in the liver and a portion is secreted in the plasma, where they are associated with high-density lipoproteins (HDLs), while PON2 is an intracellular enzyme, expressed in most tissues and organs, including the brain.
Costa, Lucio G. +4 more
openaire +3 more sources
Paraoxonase polymorphism in rabbits
Chemico-Biological Interactions, 1999Paraoxonase in serum and liver of rabbits and cattle was investigated. In serum the two substrates paraoxon and phenylacetate are exclusively hydrolyzed by alpha-lipoprotein-bound paraoxonase. In rabbit liver paraoxon is hydrolyzed only by paraoxonase, while phenylacetate is hydrolyzed by paraoxonase (20%) and additionally by an organophosphate ...
R, Zech +3 more
openaire +2 more sources
Paraoxonase: A multifaceted biomolecule
Clinica Chimica Acta, 2009Paraoxonase enzyme was first identified as a protective barrier against organophosphorus poisoning. After painstaking research spanning the last three decades, the knowledge about this enzyme has increased immensely. The present review attempts to elaborate the role of paraoxonase enzyme in normal physiology as well as provide an overview of the ...
Binita, Goswami +3 more
openaire +2 more sources