Results 191 to 200 of about 23,747 (229)

Paraoxonase Activity and Paraoxonase 1 Gene Polymorphism in Patients with Uremia

ASAIO Journal, 2003
Patients on hemodialysis (HD) show an increased risk for developing atherothrombotic events. The oxidative modification of low density lipoproteins (LDL) play an important role in the pathogenesis of atherosclerosis. In patients with uremia (chronic renal failure and HD), the increased oxidative stress induces oxidative modification of LDL.
Stefano, Biasioli, Renzo, Schiavon, Luigi, Petrosino, Emanuela, De Fanti, Gaetano, Cavalcanti, Paolo, Battaglia, Antonio, Fasolin   +6 more
openaire   +2 more sources

Paraoxonase 1 L55M, Q192R and paraoxonase 2 S311C alleles in atherothrombosis

Molecular and Cellular Biochemistry, 2012
Increased oxidative stress is known to play a role in the pathogenesis of atherosclerosis, and polymorphisms in genes encoding for enzymes involved in modulation of oxidant stress, such as paraoxonases (PONs), provide a potentially powerful approach to study the risk of disease susceptibility. Aim of our study is to investigate the possible association
Cozzi L., Campolo J., Parolini M., De Maria R., Patrosso M. C., Marocchi A., Parodi O., Penco S.   +7 more
openaire   +3 more sources

Serum Paraoxonase After Myocardial Infarction [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 1999
Abstract —HDL has been shown to prevent the oxidative modification of LDL. The antioxidant activity of HDL is believed to reside in its enzymes, particularly paraoxonase. Human serum paraoxonase (PON1) is closely associated with a specific HDL subfraction also containing apoA1 and clusterin. Recently PON1 has been implicated in
A, Ayub, M I, Mackness, S, Arrol, B, Mackness, J, Patel, P N, Durrington   +5 more
exaly   +3 more sources

Targeting paraoxonase-1 in atherosclerosis

Expert Opinion on Therapeutic Targets, 2013
Paraoxonase-1 (PON1) is a Ca(2+) dependent, high-density lipoprotein-associated lactonase which is capable of retarding/inhibiting low-density lipoprotein (LDL) oxidation. LDL oxidation is believed to be central to the initiation and progression of atherosclerosis, therefore, PON1 is considered to be atheroprotective.Relevant literature on PON1 was ...
Mike, Mackness, Bharti, Mackness
openaire   +2 more sources

Paraoxonase and coronary heart disease

Current Opinion in Lipidology, 1998
Paraoxonase (PON1) hydrolyses organophosphate insecticides and nerve gases and is responsible for determining the selective toxicity of these compounds in mammals. Human PON1 has two genetic polymorphisms giving rise to amino-acid substitutions at positions 55 and 192.
M I, Mackness, B, Mackness, P N, Durrington, A M, Fogelman, J, Berliner, A J, Lusis, M, Navab, D, Shih, G C, Fonarow   +8 more
openaire   +2 more sources

Is paraoxonase related to atherosclerosis

Chemico-Biological Interactions, 1993
Human serum paraoxonase is responsible for the hydrolysis of organophosphate anticholinesterases, however, whether the enzyme has a physiological role other than the detoxication of insecticides and nerve gases has remained uncertain. Recently, evidence has begun to accumulate of a relationship between the serum activity of paraoxonase and ...
Mackness, Michael I., Arrol, Sharon, Abbott, Caroline A., Durrington, Paul N.   +3 more
openaire   +3 more sources

Paraoxonase 1 and homocysteine metabolism

Amino Acids, 2012
Paraoxonase 1 (PON1), a component of high-density lipoprotein (HDL), is a calcium-dependent multifunctional enzyme that connects metabolisms of lipoproteins and homocysteine (Hcy). Both PON1 and Hcy have been implicated in human diseases, including atherosclerosis and neurodegeneration.
Joanna, Perła-Kaján, Hieronim, Jakubowski   +1 more
openaire   +2 more sources

Paraoxonase and coronary heart disease

Atherosclerosis Supplements, 2002
The antioxidant activity of HDL is largely due to the paraoxonase (PON1) located on it. Experiments with transgenic PON1 knock-out mice indicate the potential for PON1 to protect against atherogenesis. This effect of HDL in decreasing LDL lipid peroxidation is maintained for longer than that of antioxidant vitamins and could thus be more protective ...
Michael I, Mackness, Bharti, Mackness, Paul N, Durrington   +2 more
openaire   +2 more sources

Paraoxonase distribution in caucasian males

Chemico-Biological Interactions, 1993
Mean plasma paraoxonase activity was lower in a population of all males than in a mixed sex population with no evidence of the higher activity group. It is suggested that sex differences in plasma lipid may contribute to the observed differences, and that factors other than genetics may influence observed plasma paraoxonase levels.
F M, Williams, E, Mutch, P G, Blain
openaire   +2 more sources

Paraoxonase Activity in Athletic Adolescents

Pediatric Exercise Science, 2010
Regular physical activity may play a protective role against cardiovascular disease in adults, and paraoxonase activity may serve to mediate this effect. This study compared paraoxonase activity and that of other antioxidative agents in adolescent athletes compared with inactive youth.
Alpay, Cakmak, Dost, Zeyrek, Ali, Atas, Ozcan, Erel   +3 more
openaire   +2 more sources