Results 131 to 140 of about 8,981 (169)

Targeting paraoxonase-1 in atherosclerosis

Expert Opinion on Therapeutic Targets, 2013
Paraoxonase-1 (PON1) is a Ca(2+) dependent, high-density lipoprotein-associated lactonase which is capable of retarding/inhibiting low-density lipoprotein (LDL) oxidation. LDL oxidation is believed to be central to the initiation and progression of atherosclerosis, therefore, PON1 is considered to be atheroprotective.Relevant literature on PON1 was ...
Mike, Mackness, Bharti, Mackness
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Paraoxonase 1 and homocysteine metabolism

Amino Acids, 2012
Paraoxonase 1 (PON1), a component of high-density lipoprotein (HDL), is a calcium-dependent multifunctional enzyme that connects metabolisms of lipoproteins and homocysteine (Hcy). Both PON1 and Hcy have been implicated in human diseases, including atherosclerosis and neurodegeneration.
Joanna, Perła-Kaján, Hieronim, Jakubowski   +1 more
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Paraoxonase 1 and HDL maturation

Clinica Chimica Acta, 2015
Understanding the kinetics and function of paraoxonase 1 (PON1) is becoming an important issue in atherosclerosis. Low PON1 activity has been consistently linked with an increased risk of major cardiovascular events in the setting of secondary prevention of coronary artery disease.
Alejandro, Gugliucci, Teresita, Menini
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Paraoxonase 1 and atherosclerosis‐related diseases

BioFactors, 2019
AbstractA direct and an indirect relationship between paraoxonase 1 (PON1) and atherosclerosis exists. Given PON1's physical location within high‐density lipoprotein (HDL) particles and its recognized enzyme activity, it is certainly reasonable to suggest that PON1 facilitates the antiatherogenic nature of HDL particles.
Jelena Kotur‐Stevuljević, Jelena Vekić, Aleksandra Stefanović, Aleksandra Zeljković, Ana Ninić, Jasmina Ivanišević, Milica Miljković, Miron Sopić, Jelena Munjas, Marija Mihajlović, Slavica Spasić, Zorana Jelić‐Ivanović, Vesna Spasojević‐Kalimanovska   +12 more
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Macrophage paraoxonase 1 (PON1) binding sites

Biochemical and Biophysical Research Communications, 2008
Paraoxonase 1 (PON1), an HDL-associated esterase, is known to possess anti-oxidant and anti-atherogenic properties. PON1 was shown to protect macrophages from oxidative stress, to inhibit macrophage cholesterol biosynthesis, and to stimulate HDL-mediated cholesterol efflux from the cells. The aim of the present study was to characterize macrophage PON1
Michal, Efrat, Michael, Aviram
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Paraoxonase Activity and Paraoxonase 1 Gene Polymorphism in Patients with Uremia

ASAIO Journal, 2003
Patients on hemodialysis (HD) show an increased risk for developing atherothrombotic events. The oxidative modification of low density lipoproteins (LDL) play an important role in the pathogenesis of atherosclerosis. In patients with uremia (chronic renal failure and HD), the increased oxidative stress induces oxidative modification of LDL.
Stefano, Biasioli, Renzo, Schiavon, Luigi, Petrosino, Emanuela, De Fanti, Gaetano, Cavalcanti, Paolo, Battaglia, Antonio, Fasolin   +6 more
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Paraoxonase 1 L55M, Q192R and paraoxonase 2 S311C alleles in atherothrombosis

Molecular and Cellular Biochemistry, 2012
Increased oxidative stress is known to play a role in the pathogenesis of atherosclerosis, and polymorphisms in genes encoding for enzymes involved in modulation of oxidant stress, such as paraoxonases (PONs), provide a potentially powerful approach to study the risk of disease susceptibility. Aim of our study is to investigate the possible association
Cozzi L., Campolo J., Parolini M., De Maria R., Patrosso M. C., Marocchi A., Parodi O., Penco S.   +7 more
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Paraoxonase 1: Genetics and Activities During Aging

Rejuvenation Research, 2008
The increasing longevity of the population, one of the most important issues throughout the planet, is a very complex phenomenon (trait), likely resulting from a variety of environmental determinants interacting with and modulated by genetic mechanisms, mostly devoted to maintenance and repair. In fact, the genes involved in longevity impact upon basic
Marchegiani F., Marra M., Olivieri F., Cardelli M., James R. W., Boemi M., FRANCESCHI, CLAUDIO   +6 more
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RELATIONSHIP OF ADIPONECTIN TO SERUM PARAOXONASE 1

Atherosclerosis Supplements, 2008
Correlation of the plasma levels of insulin-sensitizing, anti-inflammatory and anti-atherosclerotic adiponectin with HDL has been demonstrated. However, its relation to HDL-bound paraoxonase 1 (PON1) has not been clarified. The association of serum PON1 activity with findings of metabolic syndrome was investigated in three age and sex-matched groups ...
Laszlo, Bajnok, Eva, Csongradi, Ildiko, Seres, Zsuzsa, Varga, Sara, Jeges, Attila, Peti, Zsolt, Karanyi, Attila, Juhasz, Emese, Mezosi, Endre V, Nagy, Gyorgy, Paragh   +10 more
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