Results 141 to 150 of about 9,486 (169)
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Variation in paraoxonase-1 activity and atherosclerosis
Current Opinion in Lipidology, 2009Paraoxonase-1 (PON1) is an HDL-associated protein of 354 amino acids with a molecular mass of 43 000 Da. It is synthesized in the liver, and in serum it is almost exclusively associated with HDL. PON1 has been reported to be an important contributor to the antioxidant and anti-inflammatory activities of HDL.
Soran, Handrean +3 more
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Systemic Inflammation, Intestine, and Paraoxonase-1
2014Serum paraoxonase 1 (PON1) has been shown to act as an important guardian against cellular damage from oxidized lipids in low-density lipoprotein (LDL), plasma membrane, against toxic agents such as pesticide residues including organophosphates and against bacterial endotoxin.
Ladan, Vakili +7 more
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Paraoxonase 1: Genetics and Activities During Aging
Rejuvenation Research, 2008The increasing longevity of the population, one of the most important issues throughout the planet, is a very complex phenomenon (trait), likely resulting from a variety of environmental determinants interacting with and modulated by genetic mechanisms, mostly devoted to maintenance and repair. In fact, the genes involved in longevity impact upon basic
Marchegiani F. +6 more
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Paraoxonase 1 Gene L55M Polymorphism and Paraoxonase 1 Activity in Obstructive Sleep Apnea Patients
2018The antioxidant enzyme paraoxonase-1 (PON1) may limit oxidative stress in the development of cardiovascular diseases (CVD) and obstructive sleep apnea (OSA). The aim of the study was to determine PON1 gene L55M polymorphism in OSA-positive and OSA-negative subjects, along with paraoxonase activity of the enzyme (PON1-act).
A, Płóciniczak +8 more
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Paraoxonase 1 and Postprandial Lipemia
2008Risk factors for coronary heart disease (CHD) include decreased insulin sensitivity and glucose intolerance, hypertension, increased body fat mass, unfavorable body fat distribution, the prothrombotic state and dyslipidemia. A clustering of these metabolic disturbances is also seen in Insulin Resistance and the metabolic syndrome.
A. Alipour +7 more
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Lead inhibits paraoxonase 2 but not paraoxonase 1 activity in human hepatoma HepG2 cells
Journal of Applied Toxicology, 2012ABSTRACTLead is an environmental toxicant of great concern for humans and animals. Lead‐induced liver damage and malfunction are partly due to a disturbance of the cellular antioxidant balance. Paraoxonase 1 (PON1) and PON2 are highly expressed in the liver and have been proposed as antioxidative enzymes.
Wanida, Sukketsiri +3 more
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Paraoxonase-1 and Cardiovascular Disease
2008The oxidation of low-density lipoprotein (LDL) in the artery wall is responsible for the initiation and progression of atherosclerosis. High-density lipoprotein (HDL) on the other hand is protective against atherosclerosis development and can attenuate the oxidation of LDL.
B. Mackness, M.I. Mackness
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Misunderstandings about paraoxonase-1
2022[No Abstract Available]
Mackness, Michael, Sozmen, Eser Y.
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The Role of Paraoxonase 1 in the Detoxification of Homocysteine Thiolactone
2009The thioester homocysteine (Hcy)-thiolactone, product of an error-editing reaction in protein biosynthesis, forms when Hcy is mistakenly selected by methionyl-tRNA synthetase. Accumulating evidence suggests that Hcy-thiolactone plays an important role in atherothrombosis.
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