Results 171 to 180 of about 29,702,919 (203)

Paraoxonase 1 and HDL maturation

Clinica Chimica Acta, 2015
Understanding the kinetics and function of paraoxonase 1 (PON1) is becoming an important issue in atherosclerosis. Low PON1 activity has been consistently linked with an increased risk of major cardiovascular events in the setting of secondary prevention of coronary artery disease.
Alejandro, Gugliucci, Teresita, Menini
openaire   +2 more sources

Paraoxonase Activity and Paraoxonase 1 Gene Polymorphism in Patients with Uremia

ASAIO Journal, 2003
Patients on hemodialysis (HD) show an increased risk for developing atherothrombotic events. The oxidative modification of low density lipoproteins (LDL) play an important role in the pathogenesis of atherosclerosis. In patients with uremia (chronic renal failure and HD), the increased oxidative stress induces oxidative modification of LDL.
Stefano, Biasioli, Renzo, Schiavon, Luigi, Petrosino, Emanuela, De Fanti, Gaetano, Cavalcanti, Paolo, Battaglia, Antonio, Fasolin   +6 more
openaire   +2 more sources

Paraoxonase 1 and atherosclerosis‐related diseases

BioFactors, 2019
AbstractA direct and an indirect relationship between paraoxonase 1 (PON1) and atherosclerosis exists. Given PON1's physical location within high‐density lipoprotein (HDL) particles and its recognized enzyme activity, it is certainly reasonable to suggest that PON1 facilitates the antiatherogenic nature of HDL particles.
Jelena Kotur‐Stevuljević, Jelena Vekić, Aleksandra Stefanović, Aleksandra Zeljković, Ana Ninić, Jasmina Ivanišević, Milica Miljković, Miron Sopić, Jelena Munjas, Marija Mihajlović, Slavica Spasić, Zorana Jelić‐Ivanović, Vesna Spasojević‐Kalimanovska   +12 more
openaire   +4 more sources

RELATIONSHIP OF ADIPONECTIN TO SERUM PARAOXONASE 1

Atherosclerosis Supplements, 2008
Correlation of the plasma levels of insulin-sensitizing, anti-inflammatory and anti-atherosclerotic adiponectin with HDL has been demonstrated. However, its relation to HDL-bound paraoxonase 1 (PON1) has not been clarified. The association of serum PON1 activity with findings of metabolic syndrome was investigated in three age and sex-matched groups ...
Laszlo, Bajnok, Eva, Csongradi, Ildiko, Seres, Zsuzsa, Varga, Sara, Jeges, Attila, Peti, Zsolt, Karanyi, Attila, Juhasz, Emese, Mezosi, Endre V, Nagy, Gyorgy, Paragh   +10 more
openaire   +2 more sources

Paraoxonase 1 L55M, Q192R and paraoxonase 2 S311C alleles in atherothrombosis

Molecular and Cellular Biochemistry, 2012
Increased oxidative stress is known to play a role in the pathogenesis of atherosclerosis, and polymorphisms in genes encoding for enzymes involved in modulation of oxidant stress, such as paraoxonases (PONs), provide a potentially powerful approach to study the risk of disease susceptibility. Aim of our study is to investigate the possible association
Cozzi L., Campolo J., Parolini M., De Maria R., Patrosso M. C., Marocchi A., Parodi O., Penco S.   +7 more
openaire   +3 more sources

Paraoxonase 1 Mutations in a Turkish Population

Toxicology and Applied Pharmacology, 1999
Human serum paraoxonase 1 (PON1) catalyzes the hydrolysis of certain organophosphate pesticides and nerve gases and so may alter significantly an individual's susceptibility to the toxicity of these chemicals. Moreover, PON1 hydrolyzes lipid peroxides complexed to low density lipoproteins (LDL) and therefore it was suggested that PON1 may be one of the
A S, Aynacioglu, I, Cascorbi, P M, Mrozikiewicz, M, Nacak, E E, Tapanyigit, I, Roots   +5 more
openaire   +2 more sources

Variation in paraoxonase-1 activity and atherosclerosis

Current Opinion in Lipidology, 2009
Paraoxonase-1 (PON1) is an HDL-associated protein of 354 amino acids with a molecular mass of 43 000 Da. It is synthesized in the liver, and in serum it is almost exclusively associated with HDL. PON1 has been reported to be an important contributor to the antioxidant and anti-inflammatory activities of HDL.
Soran, Handrean, Younis, Nahla N., Charlton-Menys, Valentine, Durrington, Paul   +3 more
openaire   +3 more sources

Systemic Inflammation, Intestine, and Paraoxonase-1

2014
Serum paraoxonase 1 (PON1) has been shown to act as an important guardian against cellular damage from oxidized lipids in low-density lipoprotein (LDL), plasma membrane, against toxic agents such as pesticide residues including organophosphates and against bacterial endotoxin.
Ladan, Vakili, Kaveh Daniel, Navab, Maryam, Shabihkhani, Nasim, Pourtabatabaei, Samra, Vazirian, Zarina, Barseghian, Seyedehsara, Seyedali, Greg, Hough   +7 more
openaire   +2 more sources

Paraoxonase 1: Genetics and Activities During Aging

Rejuvenation Research, 2008
The increasing longevity of the population, one of the most important issues throughout the planet, is a very complex phenomenon (trait), likely resulting from a variety of environmental determinants interacting with and modulated by genetic mechanisms, mostly devoted to maintenance and repair. In fact, the genes involved in longevity impact upon basic
Marchegiani F., Marra M., Olivieri F., Cardelli M., James R. W., Boemi M., FRANCESCHI, CLAUDIO   +6 more
openaire   +3 more sources

Paraoxonase 1 Gene L55M Polymorphism and Paraoxonase 1 Activity in Obstructive Sleep Apnea Patients

2018
The antioxidant enzyme paraoxonase-1 (PON1) may limit oxidative stress in the development of cardiovascular diseases (CVD) and obstructive sleep apnea (OSA). The aim of the study was to determine PON1 gene L55M polymorphism in OSA-positive and OSA-negative subjects, along with paraoxonase activity of the enzyme (PON1-act).
A, Płóciniczak, A, Baszczuk, A, Ludziejewska, H, Winiarska, S, Michalak, G, Kasprzak, D, Formanowicz, S, Cofta, E, Wysocka   +8 more
openaire   +2 more sources