Results 51 to 60 of about 20,521 (195)

Three-dimensional morphometric analysis reveals time-dependent structural changes in microglia and astrocytes in the central amygdala and hypothalamic paraventricular nucleus of heart failure rats

Journal of Neuroinflammation, 2020
Background Cardiovascular diseases, including heart failure, are the most common cause of death globally. Recent studies support a high degree of comorbidity between heart failure and cognitive and mood disorders resulting in memory loss, depression, and
Ferdinand Althammer, Hildebrando Candido Ferreira-Neto, Myurajan Rubaharan, Ranjan K. Roy, Atit A. Patel, Daniel N. Cox, Javier E. Stern   +6 more
doaj   +1 more source

Maternal obesity induced by diet in rats permanently influences central processes regulating food intake in offspring. [PDF]

PLoS ONE, 2009
Hypothalamic systems which regulate appetite may be permanently modified during early development. We have previously reported hyperphagia and increased adiposity in the adult offspring of rodents fed an obesogenic diet prior to and throughout pregnancy ...
Shona L Kirk, Anne-Maj Samuelsson, Marco Argenton, Hannah Dhonye, Theodosis Kalamatianos, Lucilla Poston, Paul D Taylor, Clive W Coen   +7 more
doaj   +1 more source

Neurogenic Hypotension and Bradycardia Modulated by Electroacupuncture in Hypothalamic Paraventricular Nucleus

Frontiers in Neuroscience, 2022
Electroacupuncture (EA) stimulates somatic median afferents underlying P5-6 acupoints and modulates parasympathoexcitatory reflex responses through central processing in the brainstem.
Stephanie C. Tjen-A-Looi, Liang-Wu Fu, Zhi-Ling Guo, Yiwei D. Gong, Anh Thi Ngoc Nguyen, Ai-Thuan P. Nguyen, Shaista Malik   +6 more
doaj   +1 more source

Effect of Social Rank on Gut Microbes and Their Metabolites of Greater Long‐Tailed Hamsters (Tscherskia triton)

Integrative Zoology, EarlyView.
Social rank in greater long‐tailed hamsters (Tscherskia triton) shapes gut microbiota composition and metabolite profiles. Dominant males exhibit a “high‐vigilance, metabolically activated” phenotype, with elevated aggression and specific gut microbiota enriched in energy‐harvesting taxa and fecal queuine.
Da Zhang, Xiaoming Xu, Zhibin Zhang
wiley   +1 more source

Inhibition of peripheral CB1 receptors modulates food intake and metabolic efficiency in obesity independently of the gut–brain vagal axis

British Journal of Pharmacology, EarlyView.
Background and Purpose Obesity involves profound disruptions in neuronal circuits, neuroendocrine communication and the endocannabinoid system. While global blockade of cannabinoid CB1 receptors improves metabolism, its clinical use is limited by neuropsychiatric side effects.
Oriane Onimus, Camille de Almeida, Benoit Bertrand, Julien Castel, Nejmeh Mashhour, Anthony Ansoult, Serge Luquet, Giuseppe Gangarossa   +7 more
wiley   +1 more source

Effects of stresscopin on rat hypothalamic paraventricular nucleus neurons in vitro. [PDF]

PLoS ONE, 2013
The effects of stresscopin (SCP) on rat paraventricular nucleus (PVN) neurons were examined using whole-cell patch-clamp recordings and single-cell reverse-transcription multiplex polymerase chain reaction (SC-RT-mPCR) techniques.
Chun-Ping Chu, Wen-Zhe Jin, Yan-Hua Bing, Qing-Hua Jin, Hiroshi Kannan, De-Lai Qiu   +5 more
doaj   +1 more source

Microglia‐Mediated Neuroimmune Response Regulates Cardiac Remodeling After Myocardial Infarction

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Sympathetic hyperactivity contributes to pathological remodeling after myocardial infarction (MI). However, the mechanisms underlying the increase in sympathetic activity remain unknown.
Menglong Wang, Jishou Zhang, Zheng Yin, Wen Ding, Mengmeng Zhao, Jianfang Liu, Yao Xu, Shuwan Xu, Wei Pan, Cheng Wei, Hong Jiang, Jun Wan   +11 more
doaj   +1 more source

Glucocorticoids and HPA axis regulation in the stress–obesity connection: A comprehensive overview of biological, physiological and behavioural dimensions

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Chronic stress, characterized by increased long‐term exposure to the glucocorticoid hormone cortisol, is increasingly linked to obesity development. Still, various knowledge gaps persist, including on underlying pathophysiological mechanisms. The aim of the current review is to provide the latest insights on the connection between stress and ...
Robin Lengton, Myrte Schoenmakers, Brenda W. J. H. Penninx, Mariëtte R. Boon, Elisabeth F. C. van Rossum   +4 more
wiley   +1 more source

Cellular Localization of Orexin 1 Receptor in Human Hypothalamus and Morphological Analysis of Neurons Expressing the Receptor

Biomolecules, 2023
The orexin system is related to food behavior, energy balance, wakefulness and the reward system. It consists of the neuropeptides orexin A and B, and their receptors, orexin 1 receptor (OX1R) and orexin 2 receptor (OX2R). OX1R has selective affinity for
Konstantina Vraka, Dimitrios Mytilinaios, Andreas P. Katsenos, Anastasios Serbis, Stavros Baloyiannis, Stefanos Bellos, Yannis V. Simos, Nikolaos P. Tzavellas, Spyridon Konitsiotis, Patra Vezyraki, Dimitrios Peschos, Konstantinos I. Tsamis   +11 more
doaj   +1 more source

The microbiota shapes the development of the mouse hypothalamic paraventricular nucleus

Hormones and Behavior
Microbes massively colonize the mammalian newborn at birth. We previously reported that the microbiota influences key neurodevelopmental events, e.g., when compared to their conventionally colonized (CC) counterparts, sterile newborn mice ("germ-free" or GF) show higher cell death in the hypothalamic paraventricular nucleus (PVN).
Milligan, Yvonne C., Peters, Nicole V., West, Gabby, Cortes, Laura R., Chassaing, Benoit, de Vries, Geert J., Castillo-Ruiz, Alexandra   +6 more
openaire   +2 more sources