Results 71 to 80 of about 406,905 (221)

Neurogenic Hypotension and Bradycardia Modulated by Electroacupuncture in Hypothalamic Paraventricular Nucleus

Frontiers in Neuroscience, 2022
Electroacupuncture (EA) stimulates somatic median afferents underlying P5-6 acupoints and modulates parasympathoexcitatory reflex responses through central processing in the brainstem.
Stephanie C. Tjen-A-Looi, Liang-Wu Fu, Zhi-Ling Guo, Yiwei D. Gong, Anh Thi Ngoc Nguyen, Ai-Thuan P. Nguyen, Shaista Malik   +6 more
doaj   +1 more source

Morphometrical analysis of the distribution of corticotrophin releasing factor, glucocorticoid receptor and phenylethanolamine-N-methyltransferase immunoreactive structures in the paraventricular hypothalamic nucleus of the rat.

, 1985
By means of the indirect immunoperoxidase technique the corticotrophin releasing factor (CRF) and glucocorticoid receptor (GR) immunoreactive nerve cell bodies and the phenylethanolamine-N-methyltransferase (PNMT) immunoreactive nerve terminals in the ...
AGNATI, Luigi Francesco, Okret S, Vale W, ZOLI, Michele, Härfstrand A, Yu ZY, Wikström AC, Fuxe K, Gustafsson J.A., Goldstein M, WIKSTROM, AC, FUXE, K, GUSTAFSSON, JA, HARFSTRAND, A, OKRET, S, YU, ZY, VALE, W, GOLDSTEIN, M, ZOLI, M, AGNATI, LF, Z.-Y. Yu, A.-C. Wikström, J.-Å. Gustafsson, S. Okret, M. Goldstein, K. Fuxe, L.F. Agnati, W. Vale, A. Härfstrand, M. Zoli   +29 more
core   +1 more source

Gut microbiota as a novel therapeutic target for eating disorders and obesity

British Journal of Pharmacology, EarlyView.
The graphical abstract highlights the bidirectional interaction between the gut microbiota and central homeostatic and hedonic mechanisms regulating food intake, which contributes to overweight and obesity. It also illustrates emerging microbiota‐based biomarkers and therapeutic strategies (including prebiotics, probiotics, postbiotics, synbiotics and ...
Solveiga Samulėnaitė, Victor Mathis, Emmanuel Darcq, Aurelijus Burokas, Elena Martín‐García, Rafael Maldonado   +5 more
wiley   +1 more source

Therapeutic access points: The roles of circumventricular organs in drug delivery and metabolic regulation

British Journal of Pharmacology, EarlyView.
The current obesity drug landscape, dominated by GLP‐1 receptor agonists and emerging multi‐agonist therapies, has reinforced that long‐term weight loss is achieved in large part through central mechanisms that suppress appetite and reshape energy balance.
Ines Martinez‐Corral, Nicholas Monaco, Daniel I. Brierley, Monica Imbernon   +3 more
wiley   +1 more source

Lesions of the Hypothalamic Paraventricular Nucleus and Norepinephrine Turnover in Rats.

Endocrinologia Japonica, 1989
The effects of bilateral lesions of the hypothalamic paraventricular nuclei (PVN), of rats with a mean weight of 260 g body, on eating habits and body weight, as well as on sympathetic nervous system (SNS) activity in interscapular brown adipose tissue (IBAT) were investigated.
YOSHIDA, TOSHIHIDE, YOSHIOKA, KEIJI, NISHIOKA, HITOSHI, KONDO, MOTOHARU   +3 more
openaire   +3 more sources

The ongoing oleoylethanolamide story: Therapeutic implications in the control of obesity and its comorbidities

British Journal of Pharmacology, EarlyView.
The global burden of obesity continues to rise, demanding effective pharmacological strategies for individuals in whom prevention alone is insufficient. Recent incretin‐based and multi‐agonist therapies have delivered unprecedented weight loss, demonstrating that the simultaneous modulation of multiple metabolic pathways can optimize body weight ...
Marzia Friuli, Alessia Campagna, Barbara Eramo, Christian Sepe, Annarita Zuena, Silvana Gaetani, Adele Romano   +6 more
wiley   +1 more source

Investigation of the mechanisms and modulation of irinotecan‐induced emesis in Suncus murinus

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Irinotecan is a widely used chemotherapeutic agent that frequently causes nausea and emesis. Its emetic mechanism of action is poorly understood and the choice of drugs to reduce nausea and emesis is largely empirical. Experimental Approach Using Suncus murinus, we examined (i) the dose–response and temporal profile of ...
Zengbing Lu, Julia Y. H. Liu, Yasuhiro Nakagami, Zitong Li, Xiaofei Huang, Man P. Ngan, Dexuan Cui, John A. Rudd   +7 more
wiley   +1 more source

Chronic oxytocin administration as a treatment against impaired leptin signaling or leptin resistance in obesity

Frontiers in Endocrinology, 2015
This review summarizes the existing literature on the effects of oxytocin administration in the treatment of obesity in different animal models and in humans, focusing on the central control of food intake, the oxytocin effects on adipose tissue and the ...
Jordi eAltirriba, Anne-Laure ePoher, Françoise eROHNER-JEANRENAUD   +2 more
doaj   +1 more source

Effects of stresscopin on rat hypothalamic paraventricular nucleus neurons in vitro. [PDF]

PLoS ONE, 2013
The effects of stresscopin (SCP) on rat paraventricular nucleus (PVN) neurons were examined using whole-cell patch-clamp recordings and single-cell reverse-transcription multiplex polymerase chain reaction (SC-RT-mPCR) techniques.
Chun-Ping Chu, Wen-Zhe Jin, Yan-Hua Bing, Qing-Hua Jin, Hiroshi Kannan, De-Lai Qiu   +5 more
doaj   +1 more source

The Edinger-Westphal nucleus II: Hypothalamic afferents in the rat

, 2013
Numerous functions have been attributed to the Edinger-Westphal nucleus (EW), including those related to feeding behavior, pain control, alcohol consumption and the stress response.
da Silva, André V., Silva, Andre V. da, Torres, Kelly R., Céspedes, Isabel C., Céspedes, Isabel Cristina [UNIFESP], Haemmerle, Carlos A., Bittencourt, Jackson C.   +6 more
core   +1 more source