Results 111 to 120 of about 12,608 (191)

CHK1 inhibitor induced PARylation by targeting PARG causes excessive replication and metabolic stress and overcomes chemoresistance in ovarian cancer

Cell Death Discovery
Chemoresistance contributes to the majority of deaths in women with ovarian cancer (OC). Altered DNA repair and metabolic signaling is implicated in mediating therapeutic resistance.
Ganesh Acharya, Chinnadurai Mani, Naresh Sah, Karunakar Saamarthy, Robert Young, Mark B. Reedy, Robert W. Sobol, Komaraiah Palle   +7 more
doaj   +1 more source

Peptide Identity of Electrochemically Deposited Polyarginine: A Critical Assessment

Chemosensors
This review examines the feasibility of electrochemical synthesis of poly-L-arginine (PArg) using repetitive cyclic voltammetry in neutral aqueous phosphate-buffered saline.
Ivan Švancara, Milan Sýs
doaj   +1 more source

Silencing PARG decreases invasion in CT26 cells.

International journal of clinical and experimental pathology
In this study we investigated the effect of poly (ADP-ribose) glycohydrolase (PARG) deficiency on the ability of invasion in CT26 murine colon carcinoma cell and its possible mechanism. We examined the effects of PARG protein knockdown by RNA interference on invasion, migration, and matrix adhesion of colon carcinoma CT26 cell line in vitro and using a
Ting, Lin, Yi, Tang, Ming, Xiao, Ming, Li, Qingshu, Li, Lian, Yang, Xian, Li, Yi, Yang, Yalan, Wang   +8 more
openaire   +1 more source

Towards Real-Time Information Processing of Sensor Network Data using Computationally Efficient Multi-output Gaussian Processes

, 2008
In this paper, we describe a novel, computationally efficient algorithm that facilitates the autonomous acquisition of readings from sensor networks (deciding when and which sensor to acquire readings from at any time), and which can, with minimal domain
Jennings, N. R., Osborne, Michael A, Ramchurn, Sarvapali, Roberts, Stephen J, Rogers, Alex   +4 more
core  

Temperature sums and climatic variations in the Parg region

Hrvatski meteorološki časopis, 2005
The growth of plants is correlated more or less closely with the accumulated air temperature above specific temperature threshold. By knowing the mean temperature sums (sum of the differences between mean daily temperature and temperature threshold) during the vegetation period it is possible to give an estimate of the temperature conditions in a ...
Vučetić, Marko, Vučetić, Višnjica
openaire   +4 more sources

Intrinsic signaling pathways modulate targeted protein degradation

Nature Communications
Targeted protein degradation is a groundbreaking modality in drug discovery; however, the regulatory mechanisms are still not fully understood. Here, we identify cellular signaling pathways that modulate the targeted degradation of the anticancer target ...
Yuki Mori, Yoshino Akizuki, Rikuto Honda, Miyu Takao, Ayaka Tsuchimoto, Sota Hashimoto, Hiroaki Iio, Masakazu Kato, Ai Kaiho-Soma, Yasushi Saeki, Jun Hamazaki, Shigeo Murata, Toshikazu Ushijima, Naoko Hattori, Fumiaki Ohtake   +14 more
doaj   +1 more source

Enzolution™ PARG Assay System Technical Manual v1

The Enzolution™ PARG Assay System is intended for use with the Transcreener® ADPR FP Assay Kit (Part #3030) to measure enzymatic activity for PARG (poly(ADP-ribose) glycohydrolase). PARG produces ADPR from the breakdown of poly(ADP-ribose) (polyADPR). It plays an important role in DNA damage repair and has been seen as a potential target for anticancer
openaire   +1 more source

Parge-work in Essex [PDF]

The Antiquaries Journal, 1922
openaire   +1 more source

The inhibition of PARG attenuates DNA repair in hepatocellular carcinoma

Molecular Biomedicine, 2023
Longpo Geng, Yaling Sun, Mingming Zhu, Hongda An, Yunzheng Li, Yuanxiang Lao, Yongli Zhang, Binghua Li, Jie Ni, Zhu Xu   +9 more
openaire   +3 more sources

Active maintenance of meiosis-specific chromosome structures in <i>Caenorhabditis elegans</i> by the deubiquitinase DUO-1. [PDF]

Proc Natl Acad Sci U S A
Strand LG, Choi CP, McCoy S, Nsamba ET, Silva N, Villeneuve AM.   +5 more
europepmc   +1 more source