Results 11 to 20 of about 12,608 (191)
The interplay of TARG1 and PARG protects against genomic instability
Cell Reports, 2023 Summary: The timely removal of ADP-ribosylation is crucial for efficient DNA repair. However, much remains to be discovered about ADP-ribosylhydrolases. Here, we characterize the physiological role of TARG1, an ADP-ribosylhydrolase that removes aspartate/
Joséphine Groslambert +10 more
doaj +5 more sources
Cancer Reports, 2023 Background Poly(ADP‐ribose) glycohydrolase (PARG) is a key enzyme in poly(ADP‐ribose) (PAR) metabolism and a potential anticancer target. Many drug candidates have been developed to inhibit its enzymatic activity.
Kaede Tsuda +3 more
doaj +1 more source
PARG: A Macrodomain in Disguise [PDF]
Structure, 2011 Our understanding of poly-ADP-ribosylation as a posttranslational modification was limited by the lack of structural information on poly-ADP-ribose (PAR) hydrolysing enzymes. A recent study in Nature (Slade et al., 2011) reports the structure of PAR glycohydrolase (PARG), revealing unexpected similarity to the ubiquitous ADP-ribose-binding macrodomains.
Markus Hassler +2 more
openaire +2 more sources
Poly(ADP-ribosyl)ation is involved in the epigenetic control of TET1 gene transcription [PDF]
, 2014 TET enzymes are the epigenetic factors involved in the formation of the Sixth DNA base 5-hydroxymethylcytosine, whose deregulation has been associated with tumorigenesis.
Bacalini, MARIA GIULIA +9 more
core +9 more sources
The Road to Survival Goes through PARG [PDF]
Cell Cycle, 2005 Unlike poly(ADP-ribose) polymerase-1 (PARP-1), poly(ADP-ribose) glycohydrolase (PARG) has long been a difficult protein to study. However, the complete absence of PARG activity was recently characterized in mice via disruption of the murine PARG gene. As expected, PARG is critical for the maintenance of steady-state poly(ADP-ribose) levels.
David W, Koh +2 more
openaire +2 more sources
Prospects for PARG inhibitors in cancer therapy. [PDF]
J Mol Cell BiolAbstract Poly(ADP-ribose) glycosylhydrolase (PARG) is an enzyme involved in hydrolyzing the ribose–ribose bonds present in poly(ADP-ribose) (PAR), which are primarily found in the nucleus. Along with poly(ADP-ribose) polymerase, PARG regulates the level of PAR in cells, playing a crucial role in DNA maintenance and repair processes ...
Hu Y +7 more
europepmc +3 more sources
Cellular bases of the RNA metabolism dysfunction in motor neurons of a murine model of spinal muscular atrophy: Role of Cajal bodies and the nucleolus [PDF]
, 2017 Spinal muscular atrophy (SMA) is caused by a homozygous deletion or mutation in the survival motor neuron 1 (SMN1) gene that leads to reduced levels of SMN protein resulting in degeneration of motor neurons (MNs).
Berciano, Maria T. +7 more
core +2 more sources
Remote Sensing, 2019 Obtaining average canopy temperature (Tc) by thresholding canopy pixels from on-ground thermal imagery has historically been undertaken using ‘wet’ and ‘dry’ reference surfaces in the field (reference temperature thresholding ...
Arachchige Surantha Ashan Salgadoe +3 more
doaj +1 more source
Frontiers in Oncology, 2021 BackgroundPoly ADP-ribose glycohydrolase (PARG) is responsible for the catabolism of PARP-synthesized PAR to free ADP-ribose. Inhibition of PARG leads to DNA repair interruption and consequently induces cell death.
Emad Matanes +19 more
doaj +1 more source
Good reduction of algebraic groups and flag varieties [PDF]
, 2015 In 1983, Faltings proved that there are only finitely many abelian varieties over a number field of fixed dimension and with good reduction outside a given set of places.
Javanpeykar, Ariyan, Loughran, Daniel
core +2 more sources