Results 81 to 90 of about 12,608 (191)

Poly(ADP-ribose)glycohydrolase is an upstream regulator of Ca2+ fluxes in oxidative cell death [PDF]

, 2018
Oxidative DNA damage to cells activates poly(ADP-ribose)polymerase-1 (PARP-1) and the poly(ADP-ribose) formed is rapidly degraded to ADP-ribose by poly(ADP-ribose)glycohydrolase (PARG).
Althaus, Felix, Bader, J., Blenn, C., Bollhalder, M., Wyrsch, P.   +4 more
core  

PARP-1 regulates DNA repair factor availability. [PDF]

, 2018
PARP-1 holds major functions on chromatin, DNA damage repair and transcriptional regulation, both of which are relevant in the context of cancer. Here, unbiased transcriptional profiling revealed the downstream transcriptional profile of PARP-1 enzymatic
Birbe, Ruth, Brand, Lucas J, Cendon-Florez, Ylenia, Chand, Saswati N., de Leeuw, Renée, Dicker, Adam, MD, PhD, Dylgjeri, Emanuela, Evans, Joseph, Feng, Felix Y, Gallagher, Peter, Gaur, Sanchaika, Gomella, Leonard G, Gordon, Nicolas, Han, Sumin, Huang, Fangjin, Kelly, William Kevin, Knudsen, Beatrice, Knudsen, Karen E, Lallas, Costas D, Leiby, Benjamin E, Mandigo, Amy C., McCann, Jennifer J, McCue, Peter, McNair, Christopher, Parsons, Theodore, Poudel Neupane, Neermala, Raj, Ganesh V, Schiewer, M J, Shafi, Ayesha A, Trabulsi, Edouard J, Visakorpi, Tapio, Zhao, Shuang G   +31 more
core   +2 more sources

Longitudinal hippocampal iron accumulation predicts episodic memory in presymptomatic Alzheimer's disease with additional influences of tau and APOE geneotype

Alzheimer's &Dementia, Volume 21, Issue S2, December 2025.
Abstract Background Elevated brain iron deposition is recognized as a characteristic of normal aging and neurodegenerative diseases, particularly Alzheimer's disease (AD), where it correlated with amyloid‐β plaques and neurofibrillary tangles. Our study aimed to investigate the relationship between longitudinal changes in hippocampal iron deposition ...
Jing Zhou, Alfie Wearn, Julia Huck, Colleen S. Hughes, Giulia Baracchini, Elisabeth Sylvain, Jennifer Tremblay‐Mercier, Judes Poirier, John C.S. C. S. Breitner, Sylvia Villeneuve, Mallar M. Chakravarty, Christine L Tardif, Claudine J Gauthier, Ana M. Daugherty, Gary R. Turner, R. Nathan Spreng, for the PREVENT‐AD Research Group   +16 more
wiley   +1 more source

In Vitro Bioeffects of Polyelectrolyte Multilayer Microcapsules Post-Loaded with Water-Soluble Cationic Photosensitizer

Pharmaceutics, 2020
Microencapsulation and targeted delivery of cytotoxic and antibacterial agents of photodynamic therapy (PDT) improve the treatment outcomes for infectious diseases and cancer.
Alexey V. Ermakov, Roman A. Verkhovskii, Irina V. Babushkina, Daria B. Trushina, Olga A. Inozemtseva, Evgeny A. Lukyanets, Vladimir J. Ulyanov, Dmitry A. Gorin, Sergei Belyakov, Maria N. Antipina   +9 more
doaj   +1 more source

Spectrum of a family of spin-orbit coupled Hamiltonians with singular perturbation

, 2015
The present study is the first such attempt to examine rigorously and comprehensively the spectral properties of a three-dimensional ultracold atom when both the spin-orbit interaction and the Zeeman field are taken into account.
Jursenas, Rytis
core   +1 more source

Sex‐specific effects of neuropsychiatric symptoms on amyloid and tau pathology and white matter hyperintensity volume in preclinical Alzheimer's disease

Alzheimer's &Dementia, Volume 21, Issue S3, December 2025.
Abstract Background Neuropsychiatric symptoms (NPS) are highly prevalent in Alzheimer's disease (AD) and may constitute both risk factors and early signs of the disease. Cross‐sectional and longitudinal studies have shown that NPS are associated with increased Aβ and tau burden in preclinical AD populations.
Aurélie Garrone, Yara Yakoub, Alfonso Fajardo, Ting Qiu, Amelie Metz, Mahsa Dadar, Valentin Ourry, Sylvia Villeneuve, PREVENT‐AD Research Group   +8 more
wiley   +1 more source

PARG Protein Regulation Roles in Drosophila Longevity Control

International Journal of Molecular Sciences
Aging, marked by a gradual decline in physiological function and heightened vulnerability to age-related diseases, remains a complex biological process with multifaceted regulatory mechanisms. Our study elucidates the critical role of poly(ADP–ribose) glycohydrolase (PARG), responsible for catabolizing poly(ADP–ribose) (pADPr) in the aging process by ...
Guillaume Bordet, Alexei V. Tulin
openaire   +2 more sources

PARG deficiency is neither synthetic lethal with BRCA1 nor PTEN deficiency [PDF]

Cancer Cell International, 2016
Poly(ADP-ribose) polymerase (PARP) inhibitors have entered the clinics for their promising anticancer effect as adjuvant in chemo- and radiotherapy and as single agent on BRCA-mutated tumours. Poly(ADP-ribose) glycohydrolase (PARG) deficiency was also shown to potentiate the cytotoxicity of genotoxic agents and irradiation.
Noll, Aurélia, Illuzzi, Giuditta, Amé, Jean-Christophe, Dantzer, Françoise, Schreiber, Valérie   +4 more
openaire   +2 more sources

Poly(ADP-Ribosyl)ation affects stabilization of CHE-1 protein in response to DNA damage [PDF]

, 2011
Post-translation modifications play a crucial role in coordinating the cellular response to DNA damage. Double strand DNA breaks (DSBs) trigger the activation of ATM and Chk2 kinases, which represent the primary transducers in the signalling cascade ...
BACALINI, MARIA GIULIA
core  

Idiopathic Pulmonary Fibrosis: Cellular Heterogeneity, Mechanisms, and Therapeutic Implications

MedComm, Volume 6, Issue 12, December 2025.
Single‐cell sequencing has elucidated cell‐type‐specific transcriptional alterations, activated signaling pathways, metabolic reprogramming, immune infiltration, and chromatin‐associated genetic mechanisms in IPF, uncovering novel therapeutic targets.
Lin Zuo, Qiongliang Liu, Defeng Ye, Jiang Fan, Liang Wu   +4 more
wiley   +1 more source