Results 1 to 10 of about 226,162 (289)
Parkin protects against traumatic brain injury through regulating mitochondrial quality control [PDF]
NeurotherapeuticsTraumatic brain injury (TBI) is a critical neurological condition, with neuronal damage being its fundamental pathological basis. However, molecular targets for the prevention and treatment of neuronal injury remain to be further explored.
Xiuquan Wu +22 more
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Parkin deficiency exacerbates fasting-induced skeletal muscle wasting in mice
npj Parkinson's Disease, 2022 Parkinson’s Disease (PD) is a chronic and progressive neurodegenerative disease manifesting itself with tremors, muscle stiffness, bradykinesia, dementia, and depression. Mutations of mitochondrial E3 ligase, PARKIN, have been associated with juvenile PD.
Nesibe Peker +2 more
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Parkin regulates drug-taking behavior in rat model of methamphetamine use disorder
Translational Psychiatry, 2021 There is no FDA-approved medication for methamphetamine (METH) use disorder. New therapeutic approaches are needed, especially for people who use METH heavily and are at high risk for overdose.
Akhil Sharma +3 more
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Frontiers in Cell and Developmental Biology, 2020 Osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) plays a key role in bone formation. Parkin, an E3 ubiquitin ligase, related to Parkinson’s disease and aging. Previous studies have indicated that Parkinson’s disease have a
Wei Zhang +14 more
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Acta Pharmaceutica Sinica B, 2022 Parkin, an E3 ubiquitin ligase, plays a role in maintaining mitochondrial homeostasis through targeting damaged mitochondria for mitophagy. Accumulating evidence suggests that the acetylation modification of the key mitophagy machinery influences ...
Xin Sun +7 more
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Parkin is protective against proteotoxic stress in a transgenic zebrafish model. [PDF]
PLoS ONE, 2010 Mutations in the gene encoding the E3 ubiquitin ligase parkin (PARK2) are responsible for the majority of autosomal recessive parkinsonism. Similarly to other knockout mouse models of PD-associated genes, parkin knockout mice do not show a substantial ...
Mareike E Fett +7 more
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Dysfunction in parkin aggravates inflammatory bone erosion by reinforcing osteoclast activity
Cell & Bioscience, 2023 Background Parkin dysfunction associated with the progression of parkinsonism contributes to a progressive systemic skeletal disease characterized by low bone mineral density.
Eun-Young Kim +10 more
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Parkin, as a Regulator, Participates in Arsenic Trioxide-Triggered Mitophagy in HeLa Cells
Current Issues in Molecular Biology, 2022 Parkin is a well-established synergistic mediator of mitophagy in dysfunctional mitochondria. Mitochondria are the main target of arsenic trioxide (ATO) cytotoxicity, and the effect of mitophagy on ATO action remains unclear.
Zhewen Zhang +8 more
doaj +1 more source
Parkin Promotes Airway Inflammatory Response to Interferon Gamma
Biomedicines, 2023 Purpose: Increased type 2 interferon (i.e., IFN-γ) signaling has been shown to be involved in airway inflammation in a subset of asthma patients who often show high levels of airway neutrophilic inflammation and poor response to corticosteroid treatment.
Kris Genelyn Dimasuay +4 more
doaj +1 more source
Journal of Traditional Chinese Medical Sciences, 2020 Objective: Buyinqianzheng Formula (BYQZF) is clinically employed in traditional Chinese medicine to treat Parkinson’s disease (PD) by improving mitochondrial dysfunction.
Haojie Ma +9 more
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