Results 91 to 100 of about 226,005 (247)
Weeding... It Isn\u27t Just For Gardens [PDF]
, 2016 Sorry, I haven’t posted in a while; I’ve been holding out until I got to the finishing stages of the Collection Development project. Yes, that’s right, for the past couple of weeks, when I was pacing up and down the stacks on the second floor, I was not ...
Farias, Jake A.
core +1 more source
Movement Disorders, EarlyView.Abstract Background Membrane contact sites are crucial for the exchange of ions or lipids and thus are critical for the function and maintenance of organelles. VPS13A is a membrane‐residing, bridge‐like protein connecting two membranes to enable bulk lipid transfer. Loss‐of‐function mutations in the VPS13A gene cause VPS13A disease.
Dajana Grossmann +10 more
wiley +1 more source
Movement Disorders, EarlyView.Abstract Background Recent advances in proteomic profiling have enabled its use as a powerful approach in elucidating molecular mechanisms underlying Parkinson's disease, enabling the identification of disease‐associated protein alterations and candidate biomarkers for diagnosis, progression, and therapeutic response.
Victoria J. Dardov +21 more
wiley +1 more source
How Soon? How Fast? Interest Rates and Other Monetary Policy Decisions in 2010 [PDF]
With the economic recovery taking hold and the Bank of Canada’s conditional commitment to keep the overnight rate at 0.25 percent expiring soon, a number of questions about the conduct of monetary policy need to be considered.
Michael Parkin
core
ChemistryOpen, EarlyView.Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel +5 more
wiley +1 more source
Linking to images and AI‐based identification tools—The only way for Flora projects to survive
PLANTS, PEOPLE, PLANET, EarlyView.Floras are comprehensive and authoritative catalogues of plants growing in an area of interest. They help people find and name plants, which is achieved by a combination of images, drawings, and text, rarely also maps. Like other catalogues (lexica, dictionaries, telephone books), Floras will not survive unless they move online and become portable ...
Susanne S. Renner
wiley +1 more source
Central Parkin: The evolving role of Parkin in the heart
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2016 Parkin is familiar to many because of its link to Parkinson's disease, and to others because of its well-characterized role as a central factor mediating selective mitophagy of damaged mitochondria for mitochondrial quality control. The genetic connection between Parkin and Parkinson's disease derives from clinical gene-association studies, whereas our
openaire +2 more sources
Rare Metals, EarlyView.ABSTRACT Intervertebral disc degeneration (IDD) is a predominant cause of low back pain, significantly impacting quality of life. Mitochondrial fitness is essential in the progression of IDD, as it regulates cellular senescence and pyroptosis. This study investigates the role of mitochondrial caseinolytic protease P (ClpP) in alleviating senescence and
Kun Wang +7 more
wiley +1 more source
A New Phenotype–Genotype Correlation for FIG4 and Parkinson's Disease
Movement Disorders Clinical Practice, EarlyView.
Iro Boura +4 more
wiley +1 more source