Results 151 to 160 of about 226,005 (247)

BAP31 Modulates Mitochondrial Homeostasis Through PINK1/Parkin Pathway in MPTP Parkinsonism Mouse Models. [PDF]

Cells
Zhang W, Meng S, Hao Z, Zhu X, Cao L, Yuan Q, Wang B.   +6 more
europepmc   +1 more source

Targeting the SIRT1‐NAT10‐GABABR1 Axis: A Novel Epitranscriptomic Approach to Mitigate Sevoflurane‐Induced Cognitive Impairment in Aging

CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.
The study reveals that NAT10 enhances GABABR1 mRNA stability via ac4A modification, leading to excessive inhibitory synaptic activation. In aged rats, sevoflurane contributes to cognitive impairment by inhibiting Sirt1 and neuronal autophagy, which subsequently disrupts energy metabolism.
Xin Xie, Wei Du, Yanmei Zhang, Xiaomin Zhang   +3 more
wiley   +1 more source

Synergism of IP3R and Parkin mutants identifies mitochondrial stress as an early feature of Parkinson's disease.

Dis Model Mech
Dileep M, Sharma A, Kasturacharya N, Nizami SK, Manjila S, Bhan A, Hasan G.   +6 more
europepmc   +1 more source

A unified mechanism for mitochondrial damage sensing in PINK1-Parkin-mediated mitophagy. [PDF]

EMBO J
Thayer JA, Petersen JD, Huang X, Gruel Budet LM, Hawrot J, Ramos DM, Sekine S, Li Y, Ward ME, Narendra DP.   +9 more
europepmc   +1 more source

Molecular Mechanisms and Therapeutic Potential of DJ‐1 in Skeletal Muscle Homeostasis and Disease

Comprehensive Physiology, Volume 16, Issue 1, February 2026.
DJ‐1 protein functions as a redox‐sensing guardian in skeletal muscle by coordinating antioxidant defense, mitochondrial homeostasis, metabolic adaptation, and anti‐atrophy signaling. Enhancing its function holds promise as a potential therapeutic strategy for muscle atrophy, ALS, and metabolic myopathies.
Yue Zhang, Menghuan Li, Xiaojing Xie, Baokai Tian, Zhenwei Bao, Xuejie Yi   +5 more
wiley   +1 more source

[The miR-30b/USP14 axis regulates mitophagy via a non-PINK1/Parkin pathway in neuronal oxygen-glucose deprivation/reoxygenation injury]. [PDF]

Zhongguo Dang Dai Er Ke Za Zhi
Bei YH, Yu K, Wang X.
europepmc   +1 more source

The Effect of Differing Levels of Intrasexual and Intersexual Selection on Survival and Reproduction Under a Heatwave

Ecology and Evolution, Volume 16, Issue 2, February 2026.
Precopulatory mating behaviour, are important for fitness and can be disrupted by heatwave's. Here we assess how differing levels of intrasexual and intrasexual selection in precopulatory mating behaviours impacts fitness responses to heatwaves. We find that the likelihood of having a brood is impacted by differences in intrasexual and intersexual ...
Karendeep K. Sidhu, Paul Caplat, Greta Bocedi, Natalie Pilakouta, Lesley Lancaster   +4 more
wiley   +1 more source

USP8-mediated mitochondrial regulation in osteoclasts is essential for skeletal development. [PDF]

Cell Mol Life Sci
Chaugule S, Yang YS, Sato T, Mayer E, Shim JH.   +4 more
europepmc   +1 more source

Salvia coccinea and Apigenin: A Natural Treasure of Lamiaceae in Pharmacological Innovation

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Salvia coccinea is rich in bioactive phytochemicals, notably the flavonoid apigenin, offering strong antioxidant, anti‐inflammatory, and antimicrobial effects. By modulating inflammatory and oxidative pathways, it shows potential for managing chronic diseases.
Muhammad Usman Khalid, Muhammad Tauseef Sultan, Muhammad Maaz, Shehnshah Zafar, Anum Shoukat, Nudrat Khursheed, Matteo Bordiga, Amna Junaid   +7 more
wiley   +1 more source

Exercise regulates mitophagy to alleviate parkinsonian neurodegeneration. [PDF]

Front Aging Neurosci
Liu C, He W, Zhang J.
europepmc   +1 more source