Results 151 to 160 of about 226,162 (289)

Zinc supplement greatly improves the condition of parkin mutant Drosophila [PDF]

, 2017
Parkinson's disease (PD) is a progressive neurodegenerative disorder in which oxidative stress is implicated as a major causative factor. Mutations in the gene encoding Parkin, a ubiquitin ligase, are responsible for a familial form of PD.
Saini, Nidhi, Schaffner, Walter
core  

Mass spectrometry‐based mitochondrial proteomics for cancer biomarker discovery

VIEW, EarlyView.
Figure.1 Schematic diagram of MS‐based mitochondrial proteomics for cancer biomarker discovery. The workflow highlights the integration of advanced technological platforms in mitochondrial proteomics and their application in cancer biomarker discovery.
Zheng Cao, ZiKun Song, Weijie Zhou, Xiaohui Liu, Yanling Liu, Peng R. Chen, Kun Qian   +6 more
wiley   +1 more source

Harnessing energy metabolism for enhanced bone defect repair: Mechanisms and therapeutic strategies

VIEW, EarlyView.
This review addresses the critical challenge of bone defect repair by focusing on the underexplored role of cellular energy metabolism. It synthesizes regulatory mechanisms in bone‐forming cells and sums up innovative strategies—leveraging cell derivatives, active factors, and biomimetic scaffolds—to modulate metabolism for enhanced regeneration.
Junting Li, Yulan Liu, Yuran Li, Yingjie Hua, Xinquan Jiang, Mingliang Zhou   +5 more
wiley   +1 more source

Deep Brain Stimulation and Pregnancy: A Case Report and Literature Review

Movement Disorders Clinical Practice, EarlyView.
Verónica Cabreira, Maria José Rosas
wiley   +1 more source

Novel Insights into Parkin–Mediated Mitochondrial Dysfunction and “Mito-Inflammation” in α-Synuclein Toxicity. The Role of the cGAS–STING Signalling Pathway

Journal of Inflammation Research
Magdalena Gąssowska-Dobrowolska,1 Gabriela Olech-Kochańczyk,1 Carsten Culmsee,2,3 Agata Adamczyk1 1Department of Cellular Signalling, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland; 2Institute of ...
Gąssowska-Dobrowolska M, Olech-Kochańczyk G, Culmsee C, Adamczyk A   +3 more
doaj  

125 years of exploration and research at Gough's Cave (Somerset, UK) 125 ans d'exploration et de recherches à Gough's Cave (Somerset, Royaume‐Uni)

Journal of the Royal Anthropological Institute, EarlyView.
Our understanding of the recolonization of northwest Europe in the period leading up to the Lateglacial Interstadial relies heavily on discoveries from Gough's Cave (Somerset, UK). Gough's Cave is the richest Late Upper Palaeolithic site in the British Isles, yielding an exceptional array of human remains, stone and organic artefacts, and butchered ...
Silvia M. Bello, Mark D. Lewis, Simon A. Parfitt   +2 more
wiley   +1 more source

Patient‐reported outcomes, postoperative pain and pain relief after day‐case surgery (POPPY): short‐term peri‐operative analgesic use

Anaesthesia, EarlyView.
Summary Introduction An increasing proportion of complex surgical procedures are being performed in the UK as day‐cases, with variable and limited follow up. Discharge prescriptions must provide adequate analgesia, while considering the safety of the patient and public, following best practice guidance and good opioid stewardship.
Anna Ratcliffe, Martha Belete, Adam B. Brayne, Harriet Daykin, Matthew Everson, William M. Hare, Katy Samuel, Lexy Sorrell, the POPPY Study Delivery Group, Katie Samuel, Xiaosu Jiang, Hayaka Amada, Lisa Ditchfield, Nkiruka Obiakpolam, Rebekah Chan, Lauren Mahoney, Rebecca Madew, Kristian Tattam, Shannon Collings, Harry Bamber, Lee Baines, Michael Thurm, Gearoid Crosbie, Felicity Hamilton, K. Hempenstall, Rabiat Umar, Alicia Ibbotson, Jolyon Flint Cahan, Tushar Das, Stuart Evans, Davina Hewitt, Sian Mckee, Joe Mellor, Mathew Patteril, Dawn Davies, Shiji Thomas, Jesty Thomas, Charlie Bevan, Natalie Kenny, Fenella Podd, Sindhu Sapru, Shilani Sundaram, Richie Field, Ellie Whittingham, Ben Wilkinson, Geetanjali Verma, Jayne Sewell, Grace Killingsworth, Sapna Chakranarayan, Beverley Wilkinson, Patricia Nicholls, Irfan Ulhaq, Mudola Manyano, Myo Thet Paing Lin, Katherine Davidson, Jane Gregory, Zoe Saunders, Rhona Bill, Antoinette Wilson, Diane Armstrong, Aku Iboroma, Abhinav Kant, Holly Davies, Manabendra Haldar, Ben Thompson, Myra Khan, Thomas Ballance, Sarah Cook, Matthew Stokle, Abby Minette, Tori Hanson, Marilyn Cooper, Natasha Mulley, Jerry Thomas, Georgina Chapman, Luke Patterson, Renjith Joseph, Praveen Gunasekaran, Dorota Potoczna, Lindsey Bennett, Kathy Dent, Kirsty Nauyokas, Sandra Pearson, Sue Spencer, Bahaael Din El Sady, Jenetha Rajendram, Annie Wood, Keiran Dudden, Caroline Kane, Sophia Hamilton, Dipayan Choudhuri, Peter Sykes, Florence Emond, Florian Fischer, Ian Edmond, Ryad Chebbout, Iona Lennie, John Ochiltree, Maria Blaney, Thalia Massa, Srinivas Magham, Ankit Kedia, Vaisakh Viswanathan, Saqib Khan, Malathi Jabanathan, Eleni Grani, Rosemary Harper, Anna Pierson, Nomonde Laxa, Allan Clark, Chinenyenwa Amaraihe, Christopher Dixon, Haneefa Ali, Purnima Narasimhan, Jessica Biggs, Keslin Greenwood, Bhavesh Gohil, James Lamert, Michael Sawaryn, Alice Gao, Lynden Nicely, Ruth Parker, Ismail El‐Kharbotly, Zheyna Konstantinova, Bilal Afzal, Abu Kalam, Holly Mcquarrie, Shuaib Sheikh, Muhammad Furqan, Praveena Chand, Freddie Weyman, Sofia Theodoridou, Fotios Gkioulos, Laura Fulton, Benjamin Cooper‐Drake, Asya Veloso Costa, Edward Gill, Laura Edwards, Henry Somers, George Budden, Deirdre Guerin, Kim Jemmett, John Cockcroft, Ahmed Hassan, Arisa Reka, Eleanor Plews, Jack Whiting, Richard Buckley, Reanne Solly, James Rand, Sarah Stirrup, Emma Ingall, Olajumoke Owolabi, Sabeen Tufail, Sindu Sridhar, Victoria Fisher, Kimberley Netherton, Amy Faunt, Jane Upsall, Daniel Stolady, Karan Verma, Sian Liddle, David Chapman, Stefan Kourdov, Daniel Jafferji, Jayakadumudiyanselage Jayakadu, Nikhil Singh, Udara Wickramanayake, Zi Soo, Hannah Neil, Johannes Retief, Kelly Barrett, Catherine Marshall, Alice Cato, James Norton, Kirsty Pearce, Oliver Main, Isabelle Mayne, Sophy Booth, Daisy Flanagan, Laura Helley, Jordan Hargreaves, Bethan Morgan, Victoria Maples, Nour Shubber, Claire Stringer, Noori Suhail, Samuel Small, Charlotte Beresford, Hoi Ching Fung, Rebecca Parker, Amy Szuman, Heather MacFarlane, Loveleena Gupta, Bunyad Naqvi, Harry Holkham, Islam Ahmed, Daniel Slane, Basant Bhattari, Vincent Chan, Abby Collins, Dean Wilkinson, Jessica Jones, Joanna Renée, Ross Gillespie, éireann Allen, Jakub Foytl, Alexandra Vine, Lucy Dobbs, Matthew Dunne, Anna Boyer, Judith Highgate, Marten Lau, Tanmay Jain, Mennatuallah Khedr, Mohamed Abdo, Ahmed Aboelezz, Sarah Goodwin, Adam Pickard, James Cartwright‐Gill, Matthew Cadd, Rory Mercer, James Andren, Sampson Anya, Alice Hipsey, Tom Searle, Amr Elmosalamy, Mennatu‐Allah Khedr, Tanya Hossain, Danielle Simpson, Juliette Kemp, Vanessa Badas, Matthew Lettis, Charlotte Jewell, Thomas Doel, Charles Kennedy, Caroline Wrey Brown, Emily Bevan, Maria Alvarez Corral, Joanna Moon, Kerry Taylor, Joanna Simpson, Clare Bird, Femi Adetunji, Nipun Mundkur, Lynsey Crowley, Emma Williams, Edyta Klata, Kerry Smith, Alison Ghosh, Katrina Cooke, Aashima Bakshi, Hannah Stansfield, Chiara Delenadis, Andrew Veal, Michael McGovern, Helena Dunn, Stella Gillies, Sarah El‐Sheikha, Clare Buffery, Emily Robinson, Anya Sheltawy, Ian Turner‐Bone, Laura Wilding, Harriet Murrant, Michaela Lloyd, Andrew Martin, Chris Jones, Elizabeth Whatling, Rachael Reddall, Kathrine Redington, Poppy Jenkinson, Fouad El‐Hibri, Berenice Cunningham‐Walker, Rachel Kearns, Iain Mactier, Munsoor Latif, Rowan Swan, Mina Zikry, Nicholas Yeo, Sarah Meredith, Emily Black, Kirsty McCrorie, Tom Baddeley, Clarissa Hocking, Faith Dalgatty, Simon Chitnis, Garry Davenport, Lisa Grimes, Georgina Singleton, Parameswari Chockalingam, Zarah Brown, Sabari Karthick Kumar, Lucy Miller, Benjamin Holdstock‐Brown, Oliver Totham, Nitya George, Priti Morzaria, Sachintha Hewage, Joseph Pease, Oliver Francis, Caroline Phillips, Vladimir Bashliyski, Rajan Mehta, Gabrielle Mendez, Alun Thomas, Elizabeth Henderson, Becky Icke, Charlotte Jones, Bethan Morse Browning, Bethan Landeg, Kevin Scott, Fiona Morris, Thomas Rae, Konara Mudiyanselage Ishan Madhuwantha Dharmarathna, Yuvaraj Doraiswamy, Lewis Isaac, Trudy Smith, Tracey Lewis, Linda O’Brien, Emma Perkins, Sunita Agarwal, Farah Nizar, Ibrahim Mostafa, Michelle Edwards, Erin Williams, Randeep Dhaliwal, Pawan Kootelu Pernu, Jane Doherty, Stephy Jose, William Flesher, Catriona Laverty, Abirami Kanniappan, Ikechukwu Igwebuike, Ramy Howaidi, Thomas Pinnock, Gabriel Ngui, E. M. Damith, E. Ekanayake, Matthew Hines, Elizabeth Stones, Karen Winter, Christopher Newell, Carys Lim, Francesca Millinchamp, Abigail Lau, Dominic Knight, Barbel Straube, David Quinn, William Gatfield, Thomas Snell, Rebecca Woolf, Jessica Casey, Hannah Hall, Katherine Lloyd Jones, Tessa Dessain, Rita Fernandez Garcia, Bashir Hamza, Nick Spittle, Nathan Griffiths, Bethel Agomoh, Abdul Alim Khan, Charlotte Morris, Benedict Jong, Andrew Orsi, Manvir Sandher, Jessica Trinquet, John Slattery, Lesley Stevenson, Rheanna Smith, Emma Moakes, Elaine Willoughby, Sarah Broadhead, Caroline Thomas, Ahmed Ibrahim, Matthew Gowshall, Maheeka Nirmalee Rajamuni, Kanmani Tumkur Lakshmikantha, John Paul, Tetiana Khinalska, Amy Longhurst, Sarah Perrin, Jack Sherlock, Kieran Bradley, Niranjala Wickramasinghe, Rosie McMahon, Charlotte Adcock, Cindy Nguik, Liaw Qian Yan, Brendan Sloan, Chloe Start, Sarah Buckley, Amy Major, Megan Pursglove, Fatima Begum, Harriet Elson, Martin Sylvester, Sagar Sanadi, Lawrence Hamshaw, Benjamin Whitby, Sarah Watson, Ahmed Daoud, Lucy Scott, James Roden, Daliya Mathew, Louise Parker, Thelma Darian, Jessica Wilson, Geraint Rees, Anna Gilfedder, Alexandra Jenkins, Katherine Davies, Thomas Clarke, Adam Mounce, Megan Williams, Niall Doherty, Santhana Kannan, Rebecca Grenfell, Saba Kouser, Balu Balakrishnan, Kiran Rohalu, Amy Orme, Angela Sawyers, Nikhil Sarma, Mohyman El Habishi, Hussein Said, Satya Anantapatnaikuni, Sean Cope, Jeevan Subramaniam, Bilal Mohammed, Catherine Chikerema, Rachel Dimery, Daniel Campbell, Jamie McPherson, Rosanne Cope, Antonia Snell, Haris Arslan, Ciaran Murphy, Janaki Pearson, Torbert Chan, Thomas Walker, Hannah Clancy, Fred Hett, Sarah Wheelwright, Tony Hodgetts, Jeffrey Tsang, Jhanielle Quindoyos, Joanna Deery, Eva Beranova, Tracy Hazelton, Aarushi Agrawal, Charlene Barter, Beata Biro, Biplob Borthakur, Chinthaka Hewavitharane, Prathiban Kumar, Michael Papadopoulos, Edward Parkinson, Rebecca Phillips, Camilla Pople, Rose‐Anne Nunoo, Dushyant Sharma, Peratheepa Vimalatharmaiyah, Dinusha Wijerathna, Tamer Younes, Anna Walton, Alexander Hollis, Frances Wensley, Suzanne Shuttleworth, Christopher Tyllyer‐Veal, David Haydock, Eleanor Jones, Nicola Bax, Oscar Hardy, Shiv Vohra, Simon Cais, Vaarisan Ganeshalingam, Karen Salmon, Benjamin Griffiths, Belinda Roberts, Jonathon Biss, Pallavi Samir Marghade, Meera Tharmaratnam, Alpen Shah, Fabiha Parveen, Alfred Ball, Amarnath Moni, Dawn Cairns, Sarah Barton, Sophie Harris, Jane Thomas, Emily Redman, Michelle Eve, Faye Benson, Kerry Goodsell, Bushena Miyesa, Michael Villaruel, Aimee Williams, Sofia Matias, Tolu Oyinlade, Nai Ramirez, Stacey Pepper, Guy Rousseau, Elena Williams, Cathy White, Ashley Hanson, Fenella Johnson, Katy Pyatt, Roshni Dholakia, Nikita Missula, Naomi Adey, Alex Edmonds, James Reilly, Mansoor Sange, Salman Ahmad, Sheena Cheung, Apurva Patil, Jennifer Phillips, Laura Kemp, Enoch Onya, Mano Sengottian, Rabia Tariq, Rajendra Pun, Ahmed Ahmed, Asad Masood, Kanika Arora, Ruairidh Morgan, Sara Yousaf, Shangeeth Shangar, Nilarne Jeyashiri, Una Poultney, Rachel Mutch, Wendy Armstrong, Laura Perry, Martina Caranza, Nils Kaufmann, Tom Georgi, Vanessa Rivers, Bally Purewal, Anneka Burch, Cathleen Chabo, Alison Swift, Rebecca Game, Rebecca Francis, Caitlin Palmer, Genessa Peters, Teresa Theobold, Daniel Watkins, Venkat Prasad, Pearl Baker, Hazel Amarado, Anna Fajardo, May Reyes, Anita Holme, Gloria Sikapite, Eunice Doctolero, Martin Ebon, Sheena Lim, Ashling Jonsson, Joy Derigay, Anna Price, Carina Cruz, Umesh Mistry, Abigail Gallagher, Kirthika Mohanathass, Matthew Woods, Laura Dan, Muriel Sirgi, Alexander Butcher, Tim Cook, Matthew Peacock, Isabel Lever, Thea Morgan, Matthew Hillier, Nicola Crowther, Sarah Hierons, Helen Burton, Tonia Clark, Gabrielle Evans, Carrie Demetriou, Maxine Brown, Joyce Katebe, Mayank Kumar Kulshrestha, Lara Allen, Ceren Senver, Katherine Meadows, Thomas Taylor, Sapphire RouXi Tan, Hebah Babar Iqbal Afridi, Junais Abdul Jaleel, Saarah Rana, Reham Deraz, Dominika Raciborska, Benjamin Straughan, Guy Hardwick, Shona Smith, Muhammad Imran Riasat, Manu Sudevan, Alasdair Turnbull, Andrew Baigey, Daniel Lynch, Joy Dawson, Nicola Butlin, Allison Roebuck, Sarah Davison, Melanie Tolson, Nicholas Ireland, Lindsay Dawson, Emma Allen, Nicola Hirschauer, Laura McAughtrie, Graham Harris, Claudia Wilson, Jack Kavalier, Euan Allan, Adam Crellinh, David Saunders, Nicola Atkinson, Mona Lehra, Adam Mowatt, Sarah Baxter, Matthew Pagan, Annie Newby, Caitlin Carr‐Knox, Aliasgar Shikiri, Rhona Sinclair, Yuvraj Kukreja, Sarah Mansoor, Rafeek Aziz, Ahmed Elfaioumy, Adela Dobru, David Berry, Mavis Cheng, Christopher Molloy, Oladele Olajolumo, Hayun Lee, Tasneem Ladha, Kandasamy Bharathi, Joellene Mitchell, Pritam Mohanty, Mhairi Davidson, Lisa Kean, Fiona Elliott, Melanie Bloor, Choopong Luansritisakul, Sarah Cockburn, Naomi Dugard, Jayne Edwards, Theresa Garratt, Barbara Linklater‐Jones, Asha Mohan, Meryl Owen, Sara Owen, Chloe Perry, Rebecca Davies, Richard Shawcross, Julie Steen, Ellen Thompson, Claire Wright, Terri Anderson, Sarah Clamp, Dan Redfern, Niall O’Reilly, Gemma Balfour, Krithi Ravi, Paul Murney, Catherine Humphreys, William Allingham, Ailidh Ramsay, Natalie Rodden, Rajeev Jha, Min Xian Lim, Chantal Roberts, John Reidy, Philip Gardiner, Alisha Chauhan, Nosaiba Ezzelarab, Olaoluwa Olaosebikan, Raj McNab, Sarah Ranson, Rebecca Pugh, Caroline Rider‐Dobson, Gul Khan, Fleur Kirkpatrick‐Croll, Vikki Cooke, Georgia Hooton, Fiona Dunning, Angela Waddingham, Deborah Walstow, Gemma Rook, Sarah Farmer, Anna Hoogkamer, Joseph Gaynor, Joseph Greatorex, Owais Shah, Shivam Patel, Anil Hormis, Jennifer Southern, Caroline Bird, Cheryl Graham, Riya Rose Mathew, Jake Warrington, Tirth Vasa, Daniel Brimfield, Claire Williams, Phillip Smith, Abby Todd, Thomas Burr, Andrew Middleton, Sophie Prestidge, Subhani Abhayawardena, Amber Hurry, Rebecca Hawes, Rachel Walker, Kath Stenlake, Elliot Haines, Jess Henry, Jess Sinclair, Beth Shartau, Isobel Browne, Sara Salim, Lucy Barnes, Anisha Patrao, Jess McLaughlin, Siyan Patel, Bassam Ali, Bibiana Bien, Oliver Tomkins, Rukia Begum, Andy Savva, Peggy Fooks, Sachin Valap, Salma Abdul Majeed, Priyanka Boylla, Sidiq Aboobaker, Emmanuel Adeleye, Thomas Ainge, Uyi Asemota, Ashni Badiani, Anuradha Balagodage, Edward Borchardt, Palangutde Dimowo, Samahir Hussein, Achese Inimgba, Rebecca Partridge, Hathurusinghage Piyaratne, Shajira Rajanayagam, Prajwal Shetty, Kay Faulkner, Temitope Filade, Swarga George, Adam Henley, Parizade Raymode, Anish Thomas, Chole Stolarski, Linda Grant, Bev Liveley, Sally white, Ajay verma, Sharon Hilton‐Christie, Simon Watts, Simon Parkin, Natalia Albuquerque, Eilidh Gillen, Stephen Waite, Amy McGinlay, Sadasivan Chinniah, Owen Davies, Surbhi Abrol, Harry Farnham, Huiching Ho, Shaan Hyder, Justin Yim, Megan Brett, Kavitej Samra, Julie Naylor, Lauren Edie, Piriyanga Kesavan, Mukur Ghosh, Alberto Vitores, Michelle Bone, Emmah Nelly, Zainab Mavani, Raquel Calcada, Suzanne Woodhouse, Roxana Ciocan, Daniele Arcoria, Terri‐Anne Baker, Natalie Temple, Kirsty Allen, Elisa Barter, Ionela Sinanovic, Kerrie Cavanagh, Graeme McLintock, Venkat Sundaram, George Woods, Amanda Jones, Rachael Farnell, Victoria Saul, Angela Pye, Annette Bolger, Bethan Roberts, Delyth Rees, Jennifer Davies, Joanne Lewis, Rachel Manley, Victoria Garvey, Caroline Lees, Sahishnu Siva Ram, Joe Woodcock, Remil Ignatius, Lorraine Spencer, Manish Adke, Paul Kim, Laura Bridge, Roz Chisholm, Christopher Balestrini, Matthew Cox, Claudia Porteous, Matthew Priest, Sara James, Karl Hunter, Anne Reddington, Jack Maher, Melanie Maxwell, Caroline Reavley, Deirdre Fottrell‐Gould, Jane Platt, Daniel Sciberras, Eleanor Jarvis, Bridie Willan, Ann Toms, Emma Vallis‐Booth, Kate Tabrett, Ciaran Scott, Farooq Afzaal, Sehajdev Bhatia, Peter Lockett, Theresa Murray, Thomas Payne, Ben Cracknell, Rishabh Sethi, Akanksha Rathod, Aleix Ugalde, Kira Farrell, Zainab Najim, Rhiannon Jones, Niamh Ward, Tineesh Mathew, Anwuli Odili, Engy Samuel, Anne Kathrine Brinck Nielsen, Marian Wassef, Dominic Linden, Lucy Connolly, Timothy Poulton, Anais Mutarambirwa, Bethany Plummer, Mavi Venditti, Ishan Lalindra Wijesinghe, Linda Ofori, Patience Nkala, Dilukshi Wickramasinghe, Louise Brassington, Suzanne Williams, Robert Musalagani, Gayzel Vallejera, Cynthia Kenala, Sabita Pokharel, Lisa Parker, Tom Hatton, Trudi Chronnell, Jennifer May, Amelia van Manen, Sarah Hudson, Hanin Ramadan, Adam Taylforth, Aaron Fleming, Amy Tucker, Kate Rahnejat, Aimee Manicom, Adel Amer, Akshay Shah, Daniel Kent, Sophie Dunin, Yashasvi Perera, Nissy Georgealias, Eoin Kelleher, John Cruise, Henry Jefferson, George Gladstone, James Davies, Chris Morrell, James Goetz, Nikki Fry, Claire Preedy, Lucas De Carvalho, Eve Fletcher, Suzy Dean, Qian Zhang, Maisie Harvey, Elyanna Choi, Benjamin Tanner, Stephanie Edmunds, Sachin De Stone, Bethan Gay, Jack Walker, Kai Li, Ruth Child, Muhammad Zarif Miszua Anuar, Jemima Henstridge‐Blows, Edward Cope, William Ellis, Yoshimi Ito, Merin Joselin George, Sumreen James, Juliya Pearl Joseph Johnson, Deepshika Mehra, Dominic Wilson, Pranav Osuri, Sumant Shanbhag, Monisha John, Jack Houghton, Jason Patel, Ramdas Howard, Nyree Jackson, Blessing Okoko, Tegan Taylor, Kyle Chang, William Rea, Annu Abraham, Neelesh Kumar Mohan, Emma Prendergast, Craig Pinner, Kimberley Benjamin, Eleanor Keeling, Marcus Beadle, Jonathan Robinson, Bijay Mallikarjuna, Georgina Highton, Matt Rendell, Temi Ijiwole, Monica Horvath, Chandran Jeganathan, Sejung Park, Matthew Titterington, Victoria Estlin, Scarlett Wood‐Gismera, Amarjeet D Patil, Pei Shan Lim, Simon Hatton, Karl Braid, Mohammed Attia, Kailash Bhatia, Teodora Orasanu, Khaled Ahmed, Kelly Hubbard, Katie Dorr, Catherine Wyatt, Sarah Shephardson, Dinesh Rao, Anand Shirgaonkar, Farheen Samad, Harsimran Kaur Surinder Singh, Paul Parker, Samuel Saad, Lynn Osborne, Rayya Alharthi, Bret Claxton, Ciaran Clarke, Simon Cousins, Chuyan Yu, Ravi Mani, Elizabeth Smithson, Vei Tay, Kate Dalgleish, David Cronin, Kelly Sugden, Andrew Parrish, Rick Leggatt, Ian Chadderton, Beth Pullen, Helen Stanworth, John Dereix, Gabriella Tutt, Eliza Davies, Trudy Parfrey, Sharon Turney, Joanne Knight, Stephanie Berry, Timothy Bonham, Sarah Taylor, Wendy Stoker, Amy Foster, Jennifer Hooper, Thomas Padwick, Josephine Gwinnell, Calum Smith, Daniel Lenton, Sam Stafford, Chetan Pataki, Christopher Sadler, Rebecca SJ Gibson, Ellen Gorman, Monica Chogle, Ruth Ford, Matthew Gillen, Abdul Raziq Hider, Max Zammit‐Maempel, Jenny Eastwood, Aoife Deeny, Timothy Durkan, Renata Klopotowska‐Arszulowicz, Victoria Prabhu, Marino Lagadi, Ahmed Makky, Roland Amoah, Anna Williams, Fiona Glarvey, Tom Abberton, Richard Scowcroft, Will Simpson, Iwan Williams, Judith Oguguo, Jodie Fletcher, Marco Azize, Stephen Davies, Daniel Young, Carol Jeffs, Vas Vasudevan, Mel Caswell, Stephen Preston, Lisa Elawamy, Leonie Benham, Favour Adoghe, Amy Barnett, Ailsa Uttley, Chris Hale, Haritha Harrision, Kayleigh Mountford, Ashleigh Wignall, Ron Manuel, Dona Solichan, Ancy John, XVL Holmwood, Henry Sergeant, Bertie Garbutt, Sophia Strong‐Sheldrake, Jessica Evans, Jo Chown, Drew Goodchild, Stephanie Walsh, Beena Eapen, Ginny Griffiths, William Carroll, Emma Ewins, Nicholas Brown, Jessica Warr, Annabel Plumb, Carolyn Mansfield, Karen Gilbert, Esther Odesanya, Karen Hillyer, Georgina Rogers, Loku Warnapura, Orla Gillman, Ishita Bobba, James Gallagher Chin, Marwan Nassar, Michael Maseha, Nimali Puwackwaththa, Poojani Arulrajah, Runil Shah, Sabrina Saaid, Iain Cummings, Christopher McKee, Timothy Langdon, Victoria Allinson, Emily Johnson, Lydia Shatananda, Amman Mader, Zuzana Hutkova, Simon Grant, Pritesh Mistry, Antonia Stone, Shailendra Krishniah, Gopi Macherla, Neethu Raj, Nicholas Scallan, Holly James, Harminder Matharu, Emily Dana, Benjamin Robert Stevens, Sam Bullard, Charles Templeman, Sofia Farina, Keri Joslyn, Hans van Huellen, Charlotte Quick, Yolanda Baird, Benjamin Fenner, Anthony Short, Joshua Cooper, Jordan Coyle, Gemma McManus, Karen Aspey, Sazini Mtunzi, Cheryl Finch, Jane Olverson, Tobechukwu Eneh, Jayne Windebank, Saskia Port, Valerie Parkinson, Jennifer Anderson, David Wilcock, Susan Pemberton, Rebecca Smith, Tracey Taylor, Caroline Tierney, Ryan O’Leary, Lee Woolsey, Caroline Daniel, Emma Collins, Nagendra Prasad, Zaid Saghir Ahmed, Michael Nesbitt, Hannah Henderson, Zhen Xin Ong, Sherin Abdelbadiee, Emily Ruschen, Mechael Rafique, Luke Barge, Niamh Hetherington, Safa Asghar, Isabel Clark, Faiq Khan, Kevin Perera Padukkage, Daanyal Ilyas, Henriette Leser, Rifah Islam, Jaskiran Sandhu, Alys Williams, Jasmin Peacock, Alexander Van Loggerenberg, Alice Foulkes, Paige Wilkins, Beth Hancox, Maryam Umar, Sofia Korre, Namrata Kalra, Neha Isaac, Raaid Humdani, Grainne Moon, John O’Donoghue, Clodagh Krasucki O’Dowd, Jordan Lau, Emma Lee, John Conor Gildea, Aaron Duff, Aimee Thompson, Aidan McKinley, Sumayer Sanghera, Ahmed Atewah, Louise Murray, David Shaw, Gabrielle Harrison, James Morrison, Athira Sasidharan, William Stagg, Rebecca Morris, Vaishnavi Banagi Devaraju, Sara Piva, Luke Boyes‐Varley, Emily Gargan, Deepak Chhabra, Charlie Billington, Tom Casey, Robert Wiltshire, Chiu Kuan Joseph Lee, Claire Osey, Lindsay Rogers, Cheryl Lindsay, Chloe Bascombe, Fardowsa Ahmed‐Timms, Natalie Agius, Annamaria Wilce, Javen Ramsami, Charlotte Coekin, Charlotte Humphrey, Katie Preston, Suzanne Roffe, Karen O’Toole, Stephanie Worrall, Ramy Khalil, Emma Langridge, Yasmin DeAth, Matthew Bayliss, Anthony Pickering, Amy Ashford, Caroline Horrobin, Heather Hudson, James Richardson, Karen Bobruk, Kate Bell, Katherine Pass, Katie Foy, Katherine Saunders, Lewis Powell, Lydia Jones, Mary Trevelyan, Molly Monk, Rosina Jarvis, Rowena Johnson, Toni Farmery, William Hillier, Amit Dalvi, James Sylvester, Jack Khalil, Matt Wiles, Abdelrahman Eleshmawi, Jaden Groves, Divyadarshni Vadivel, Reena Pal, Louis Rose, Jun Jie Lim, Alexandra Little, Michelle Agboola, Mark Plews, Tom Kingston, Natalie Lake, Hannah Dudhill, Freya Brownlow, Colaco Rohan John Francis Ronald Harris, Mhd Alaa Aldin Al Haffar, Rachel Lee, Branson Ng, Yvan Liew Jing Ying, Belal Yasin, Alistair Sawyerr, Mabli Davies, Joseph Hamlyn, Shilpee Kumari, John Finnerty, Helen Carr, Emma Lowe, Amrith Malhi, Patrick Eagle, Jane Stratton, Catherine Cromey, Brigitte Baxter, Mohammed Abdelmonem, Nicholas Palfrey, Joshua Feddon, Swyn Lewis, Lara Sabry, Adam Wood, Matt Irvine, Amanda Ebejer, Roopali Telang, James Ellis, Ahmed Abdella, Catherine Archer, Bharani Premkumar, Jenny Travers, Amanda Cook, Caradog Thomas, Marie Jones, Gemma Smith, Mark Baker, Claire Chapman, Sharon Storton, Marta Blanco Cabana, Nabil Farooqi, Priyankara Indrajith Marasinghe, Vinita Sangai, Munazzah Zaidy, Sylvia Martin, Shiba Aggarwal, Chloe Hall, Hemesh Shewale, Joshua Fisher, Babatunde Osokoya, Vasiliki Kalogianni, Kruthika Ramamurthi, Afnan Mahmoud, Nora Anna Nagy, James David Alexander Wood, Akash Chowdbury, Amy Ackerley, Mickey Shah, Laura Kent, Laura Barkess, Rebecca Seaman, Laura Adams, Jen Assimakopoulos, Sophia Gkolomazou, Bella Giles, Julia Karwat, Reem Ibrahim, Anna Tunnicliff, Rochelle Pierre, Catherine Sheehan, Yue Wu, Alice Paterson‐Brown, Daniel O’Neill, Farrah Akkouch, Amrinder Sayan, Khatra Adam, Jamie Gonzales, Thomas Chambers, Corinne Rimmer, Lucy Brown, Della Solichan, Karen Fong, Ebi Uchechukwu, Karen Burns, Steve Peters, Deborah Power, Helen Morris, Jane Winder, Rosendelle Soriano, Aileen Menzies, Julie Le Bas, Susanna Crayton, Hilary Thatcher, Katie Mcguire, Ahmed Osman, Clare Finney, Nicholas Turner, Caitlin Spooner, Conor Murtagh, Jenny Olsson, Marianette Axalan, Anna Broderick, Burt Vergara, Kevin O’Reilly, Benedicte Sjoflot, Hywel Garrard, Stephen Thompson, Abigail Pemberton, Julie Melville, Diane Daniel, Katrina Mullane, Bethany Suggitt, Clair Rainford, Rebecca Mills, Brenda Pimlott, Taylor Doherty Walls, Susan Hopkins, Kai Zai, Oluwafunmilayo Oyekan, Vishramb Mattadeen, Dagnija Panter, Laura Scott, Moe Kishima, Matthew Hancock, Richard Stewart, Emily A Russell, Charlotte Willis, Shilpi Sethi, Gokul Sagar Bailur, Kurun Kumar, Patricia Avila del Puerto, Teena Babu, Felicity Williams, Richard Ramsaran, Sreela Jonnada, Gareth Allen, Sam Hewitt, James Roe, James Shuttleworth, Jennifer Entwistle, Victoria Waugh, Katie Edwards, Faye Bowden, Sarah Louise Richardson, Vivian Pringle, Anna Sharpe, Helen McNamara, Grainne Garvey, Vani Bhageria, Joanna Gumley, Lucky Angashang, Laura Wilson, Mirza Anwar Ahmed Baig, Tom Bedwell, Nitish Upadhyay, Jonathan Collins, Helen Bull, Emily Rice, Mark Gallagher, Amy Hughes, Hannah Quigley, Sally Bell, Bethany Foster, Elin Barham, Anuradha Kurvey, Oliver Froud, Christopher Fine, Natasha Lawes, Rachel Hoyle, SydneyAwuor Omondi, Wendy Goddard, Janice Hartley, Stephen Duberley, Danica Aspin, Sanjiv Sharma, Genevieve Mullins, Alexandra Gray‐Renfrew, Zarina Bibi, Manab Haldar, Tammy Murray, Caroline Dickens, Precious Vasvi, Louise Wilcox, Prashanth Parvatha Reddy, Michael Jarvis, Dhruti Pandya, Kerry Starkey, Matthew Huniak, Moheyelden Salahelden, Mettha Wimalasundera, Nicholas Ronan, Sunita Gurung, Rachel Morris, Joseph Pick, Emma Cooper, Andrew Plews, Salman Islam, Nabeel Chowdhury, Yara Ahmed, Mark Higgins, Vinodkumar Changarangath, Michelle Davies, Minnie Gellamucho, Lucy Bailey, Sian Wisbey, Martin Booth, Maxine Owen, Simone Locker, Jane Delaney, Dominic Jesudoss, Alison Brown, Elizabeth Nicol, Kaylee Gauntlett, Kim Hulacka, Colum Slorach, Rachael Robertson, Thomas Aitken, Michael Pretswell, Antony Sanjiev Ratnasingham, Charles Wallis, Francesca Wing, Michele Poole, Alexandria Page, Isaac Brookman, Sophie Beverley, Louise Nimako, Ellen Jessup‐Dunton, Yu Shen, Rupert Lees, Gail Murphy, Harry Barnett, Andrew Kermode, Kristina Bull, Indhuja Rajkumar, Merlin James, Jane Harding, Manish Das, Julie Houghton, Catherine Kloppenborg, Samantha Weller, Lisa Clutterbuck, Sarah Davies, Sabba Aziz, Sarah Beckley, Sunil Chaurasia, Thomas Smith, Lauren Pout, Nicholas Smith, Hannah Winder, Jennifer Butler, Lizzie Ribey, Paul Bramley, Kate Gamble, Jane Booker, Anna Galvin, Alice Nicholson, Tamsin Gregory, Charlotte Dowson, Nicholas Yu, Liz Shenton, Kellie Butterfield, Ginny Clarke, Helen Henson, Lindsey Stephens, Lisa Armstrong, Marcela P. Vizcaychipi, Laura Martins, Jaime Carungcong, Kribashnie Nundlall, Florison Canlas, Emily Futter, Carina Bautista, Rhian Bull, Julie Logan, Alexandra Schookmeesters, Patricia Costa, Katharine Balfour, Patrizia Simonato, Ilhan Wardhere, Tamsyn Glover, Ben Wooldridge, Claudia Gardiner, Samuel Worsley, Penny Parsons, Camilla Stagg, Judy Shirley, Angela Day, Inderjit Atwal, Sundar. Raj Ashok, Shilen Shah, Eram Majeed, Sonali Mohite, Daniel King, Lucy Partridge, Edward Hare, Nuwan Dahanayake, Islam Abousharkh, Thisaru Wellalage, Vlera Qerkezi, Meenu Payyappilly, Harriet Gardiner, Karen Stacey, Jonathan Dunne, Sadia Habib, Sanooj Soni, Stephanie Ivie, Emily Russell, Elaine Viloria, Eliza Speranzini, Maura Roy, Kim Rhodes, Anukriti Panda, Olumayowa Ogunwemimo, Quoc Nguyen, Dineesha Menon, Chiwen Lin, Lija Joy, James Emerton, Mark Caballes, Lauren Whitestone, Emily Rosewood, Surpreet Grewal, James P. Ruddy, J. P. Ruddy, Audrey McAlpine, Roisin McGovern, R. Adam, Catriona Anderson, S. Julius, Peter Sandbach, Su‐Mei Tham, Muhammad Azeem, Mirac Demirbag, Amr Youssef, Mostafa Salaheldeen Mohammed, Christopher Wild, Rebecca Flanagan, Emma McKenna, Elena Apetri, Scott Latham, Danielle Hollick, Robert Davidson, Nidhi Gautam, Rakhi Ghosh, Mary James, Darryl Braier‐Lorimer, Darshana Ranasinghe, Vitor Goncalves Savoia, Rajesh Shankar, Shahid Johar, Jasmin Pandhal, Xiaobei Zhao, Jincy Joseph, Alice Mihaela Balaican, Reuly Vicente, Jackie Evans, Ahashia Qureshi, Chimenime Ede, Ogwa Tobi, Luke Hoskins, Mike Blundell, Lucy Reid, Ellie Granger, Samuel Dale, James Bennett, Nina Llewellyn, Samuel Gowshall, Shivraj Patel, Haytham Lebari, Anna Surridge, Chris Pennington, Nishaan Nayar, Mo Williams, John O’Rourke, Barbara Ribeiro, Harriet Carter, Laura Griffiths, Ben Richardson, Claudia Dyball, Jo Ingham, Dan Wise, Adulrhman Abelmagd, Charlotte Henson, Amy Gomes, Hannah Foster‐Rain, Ashiq Mohamed Salim, Sunil Jeevan Dasari, Amin Elkhawad, Khadija Ranjha, Robert Stroud, Anushka Sieunarine, Iain McLure, Kathryn Simpson, Matthew Cole, Alistair Gales, Amy Nixon, Mohammed Mahgoub, Tom Woodhouse, Natasha Jones, Louise Leonard, Elizabeth Mcgough, Olivia Tiley, Ranya Alias, Charlotte Eglinton, Kerry Paradowski, Michaela Cox, Karen Rahilly, Gail Williams, Matthew Forester, Ciprian Cociuba, Chris Perry, Amy Yeoman, Dagmar Holmquist, Stephen Daly, Zara Al‐Faham, Ehmed Chohan, Karim Tawfik, Zoheir Boutaleb, Daniel Crossman, Ahmed Aly, Tim Warrener, Shun Yamanaka, Victoria Hodgson, Charlotte Williams, Julie Alderton, Rachel Franklin, Abigail Patrick, Eden Wildman, Johanne Hamilton, Gabriella Smallwood, Pinky Thu‐Ta, Glen Marsh, Francesca Onofri, Chris Gordon, Angela Downing, Heidi Hollands, Fiona Reed, Tracy Ward, Noah Boateng, Natasha Wilmshurst, Paola Vasconcelos, Ada Nweze, Lisa Shainberg, Samuel King, Amit Das, Elaine Freeman, Katie Latham, Liam Kitto, Sheena Melendrez, Emma Abraham, Victoria Yates, Simon Clark, Laura Garner, Fiona Elliot, Jyothi Hosahalli Lakshmanachar, Elena Marco Illana, Rincy Kurian, Louise Pyrkos, Catherine Willshire, Roberta Depretto, Sivaprakash Vaitheeswaran, Julie Knight, Kristina Doab, Claire Palombo, Gbemisola Jenfa, Tariq Chaudhari, Jozen Obrique, Rhidian Jones, Lara Jesani, Sophie Jones, Thomas Wand, Robert Wight, Lucy James, Tristan Hawkins, Rhiannon Harling, Lauren Nunnerley, Alysha Hancock, Sudha Garg, Jonathan Bates‐Powell, Aparesh Mandal, Harrison Plumpton, Uzma Khan, Kevin Howard, Jane Woods, Elva Wilhelmsen, Darylile Guledew, Julie North, Cherry Ann White, Wendy Harrison, Donna Griffiths, Helen Sutherland, Amy Garrod, Charlotte Kelly, Manjunatha S. V. Patel, Carolyn Smith, Swarnendu Dey, Vivek Trivedi, Robert Brown, Raeesa Patel, Danielle Teasdale, Aidan Butler, Tanvi Ujoodha, Melanie Taylor, Ashleigh Lovett, Adam Mosley, Katherine Pagett, Ifan Teifi Rees, Alison Tucker, Ellen Mary Knights, Jeannie Bishop, Sion Lewis, Abhik Bhattacharjee, Alice Chubb, Cyrille Cabaret, Katrine Thorup, Miles Seavill, Seray Gunes, Alex Mattin, Bethany Goulson, Kilda Carpenter, Rebecca Lee, Joanne Fong, Geraldine Hambrook, Ben Chandler, Bhavya Janardhana, Alex Dunn‐Roberts, Janine Armstrong, Kerry Elliott, Laura Barman, Alison Turnbull, Anna Waine, Dana Groom, Rachel Harrison, Agnieszka Kubisz‐Pudelko, Jennifer Driver, Lucy Pippard, Linda Howard, Karl Fuchs, Nigel Beer, Alison Lewis, Kate Beesley, Jess Foster, Mark Giza, Joyce Yeung, Mithila Govindaraju, Arlo Whitehouse, Mehwaish Zulfiqar, Jo Gresty, Celina Maliaykal, Ellie Reeves, Kyrie Wheeler, Shreevastchavan Rajasekar, Rifah Zia, Amrish Gujrathi, Sharique Anwar, Heather Willis, Faye Moore, Elizabeth Martin, Helena Purle, Sumeya Faysal, Balkrishna D. Nimavat, Alexandra Clement, Rohit C Sheth, Margaret Carmody, Sam Staffod, Karthik Vasudevan Iyer, Bryan Wong, Tammy Bellamy, Teresa Melody, Emily Butler, Clifford Shelton, Stephanie Teh, Arosa Lin Lok Heng, Emily Coffey, Samantha Moore, Jonathan Casson, John Schutzer‐Weissmann, Maxime Caron‐Goudreau, Lucy Liu, Anish Thillainathan, Mike Frow, Wing Sze Sara Hui, Zara Eagle, Thomas J Craig, Anthony Carver, Archana Depala, Nile Sharma, Sean O’Reilly, Nick Moss, Lawrence Rory Kidd, Rasangi Suraweera, Katy Lee, Alexander Rond‐Alliston, Kayleigh Collins, Sahil Gupta, Hannah Swinburne, D Sean Cope, Martyn Ezra, Songtum Saltrese, Charlotte Jenkins, Aarif Ali, Kulpdeep Nijjar, Yanisa Wannasuphoprasit, Sneha Gurung, Serina Sidhu, Reet Nijjar, Sioned Phillips, Kerry Fisher, Caroline Fryer, Lorinda Essuman, Girgis Abadi, James Bigley, Tamanna Shikh‐Bahaei, Rachel Mills, Ceri‐Ann Brigid Lynch, Sioned Davies, Katy Gilbert, William Dace, Kaitlyn Egan, Sammy Sharif, Amy Wright, Lucy Griffin, Elliot Phillips, Stella Arthur‐Quarm, Zak Deere, Steffan Morgan, Kiri Armstrong, Anya Jones, Pallavi Dasannacharya, Adam Green, Francesca Elwen, Charlie Brock, Chris Watson, Nishanth Sandrasegaram, Patrice Forget, Emma Rhodes, Amanda Gould, Onyinyechi Oziogu, Fiona Rixon, Nicola Price, Karen Norris, Vicky Taylor, Lynn Mackay, Oliva Hitch, Marc Place, Kirsty Bromley, Andrew Hunter, Sarah‐Anne Milne, Li Lin Hong, Alistair Morris, Kebba Konteh, David Ford, Chisomo TengaTenga, Chia‐Ping Chou, Sophie Lubbock, Julie Grundy, Anju Thomas, Cecilia Peters, Kathleen Holding, Shifa Patel, Alison Chambers, Lois Daniels, Thomas Swainstone, Barbara Nowicka, Julia Sampson, Andrew Clark, Scott Calvert, Collette Burns, Danielle Gilmour, Mark Wilson, Debbie Callaghan, Patrick Thorburn, Hajnalka Huszka, Matthew Farrant, Juliet Ariel, Ahmed Yousef, George Gathercole, Cicely Culmer, Ranvir Singh, Johnlee Joseph Kuragala, Lavanya Thakur, Arpan Sashankar, Jean Kinder, Heather Savill, Avril Lee, Lilian Eze, Martyn Clark, Martina Coulding, Roxanne Gray, Chris Coppletone, Lizzie Freeman, Alison Gordon, Perumbadage Tharanga Prasad Gunarathna, Rory J. Heath, William Hughes, Samuel McAleer, Stuart McPhail, Felix Robins, Jessica Sinclair, Luke Solomi, Joanna Wilson, Thomas Woodward, Yun Chi Yu, Elliot Catchpole, Aparna Cockrell, Emma Lang, George Linfield‐Brown, Helmi Burton‐Papp, Matt Duffield, Emma Killick, Kate Edgeley, Claudia Lameirinhas, Chand Ishwin, Clarissa Metz, Karen Hudson, Suresh Kondi, Nicole Sproul, Rhoda Odeyemi, Nadine Darnley, Michael Salloum, Vivek Kumar Sinha, Sarah Jayne Beresford, Jack Haslam, Sheila Munt, Louise Howard‐Sandy, Rebbekka McCullough, Jennifer Kujacz, Fathy Elshazly, Imran Riasat, Andrew Baigie, Fiona Ramsden, Gabrielle Grounds, Roxana Sandhar, Julian Giles, Tracey Shewan, Gail Pottinger, Sophie Holden, Christian Balajadia, Melanie Hutchings, Linda Park, Tania Nightingale, Thomas Boddington, Rachel Kelland, Joanna Czylok, Timothy Richards, Nicholas Aveyard, Kevin Windsor, Shemin Kovammal, Adeela Muzaffar, Raman Mobasheri, Uashar Badakhshan, Rob James, Sophie Knipe, Phoebe Olabode, Ben Curry, Liam Longville‐smith, Charles Gregory, Sulakshan Ranaweera, Christopher Timmis, Jacyntha Khera, Farooq Brohi, Mohammed Aleem, Magdalena Stefaniak, Sarah Easby, George Greig, Mohamed Abdelsalam, Carol Adams, Ana Teixeira, Sarah Purvis, Nicole Harris, Fe Hernandez, Susan Crawford, Eve Wilson, Anna Rookes, Simon Sinclair, Elaine Siddle, Barbara, Deborah Wilson, Hillie Corr, Helen, Konstantinos Miltsios, Muska Miller, Evelina Russell, Brian Herath, Sangita Kindred, Giada Bitente, Lily Kirkpatrick, Chinwe Obiozo‐Jumbo, Latifah Harris, Kayleigh Gilbert, Vikas Vijay Tripurneni, Sian See Tan, Aastha Chawla, Ben Shelley, Alfie Lloyd, Gary Paul, Claire Twomey, Ben Shelley, Aditya Kuravi, Klaus Mahler, Matthew Byrne, Emma Sherry, Mukundan Ramanujam, Sohail Bampoe, Iby Adedugbe, Yuhan Peng, Mohammed Khaku, Dona Saha, Amalia Priovlou, Deborah Smyth, Georgia Bercades, Chimverly Diaz, Gladys Martir, Ingrid Hass, Laura Gallagher, Maria Zapata Martínez, Karen Beaumont, Donna Durrant, Thomas Bate, Katherine Whitely, Beata Buga, Mark Rockett, on behalf of the Research and Audit Federation of Anaesthetists in Training, Gianluca Trisolini Longbardi, Helen Iliff, Brett Doleman, Jonathan Barnes, Katie Preston, Thomas Davies, Sarah Hudson, Adam Boulton, Aravind Ramesh, Jonathan Bower, Suzanne Harrogate, Swati Gupta, Tom Baumer, Yolande Squire, Calum Taylor, Oliver Barker, Carys Lim, Kathleen Wolff, Chiu Lee, Sophia Beeby, William Denehan, James Ward, Mayur Murali, Matthew Luney, Elliot Yates, Christopher Dixon, Matthew Baldwin, Beth McElroy, Elizabeth Thompson   +2083 more
wiley   +1 more source

Deficiency of parkin causes neurodegeneration and accumulation of pathological α-synuclein in monkey models

The Journal of Clinical Investigation
Parkinson’s disease (PD) is characterized by age-dependent neurodegeneration and the accumulation of toxic phosphorylated α-synuclein (pS129-α-syn). The mechanisms underlying these crucial pathological changes remain unclear.
Rui Han, Qi Wang, Xin Xiong, Xiusheng Chen, Zhuchi Tu, Bang Li, Fei Zhang, Chunyu Chen, Mingtian Pan, Ting Xu, Laiqiang Chen, Zhifu Wang, Yanting Liu, Dajian He, Xiangyu Guo, Feng He, Peng Wu, Peng Yin, Yunbo Liu, Xiaoxin Yan, Shihua Li, Xiao-Jiang Li, Weili Yang   +22 more
doaj   +1 more source

The relationship between the cannabinoids and cardiac remodelling: A comprehensive review of pivotal mechanisms and emerging evidence

British Journal of Pharmacology, EarlyView.
Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska, Marta Baranowska‐Kuczko, Hanna Kozłowska   +2 more
wiley   +1 more source

SOD2‐Superoxide Metabolic Axis Regulates Mitophagy and Modulates TKIs Sensitivity in Head and Neck Squamous Cell Carcinoma

Cancer Science, EarlyView.
Our findings provide compelling evidence that the SOD2‐superoxide metabolic axis functions as a mitochondrial redox checkpoint that governs mitophagy and ultimately shapes TKI sensitivity. ABSTRACT Superoxide dismutase 2 (SOD2) has been implicated in head and neck squamous cell carcinoma (HNSCC), yet its mechanistic contribution in regulating tumor ...
Wan‐Hang Zhou, Shuo‐Jin Huang, An‐Xun Wang   +2 more
wiley   +1 more source