Results 211 to 220 of about 226,162 (289)

From Covalent Traps to Fluorescent Beacons: The Expanding Arsenal of Chemical Probes for Studying Ubiquitin and Ubiquitin‐Like Proteins

Angewandte Chemie, Volume 138, Issue 13, 23 March 2026.
A large variety of chemistry‐based ubiquitin probes have been developed. ABSTRACT Ubiquitin (Ub) and ubiquitin‐like proteins (Ubls) orchestrate diverse cellular processes through reversible post‐translational modification of target proteins. Their conjugation is governed by a cascade of E1 activating, E2 conjugating, and E3 ligating enzymes, while ...
Saibal Chanda, Wenshe Ray Liu
wiley   +2 more sources

Icaritin ameliorates mitochondrial dysfunction and autophagy impairment in cellular models of Alzheimer's disease. [PDF]

Front Aging Neurosci
Xia L, Liu T, Li Z, Ao X, Chen Q, Zhou X, Jiang Q, Huang N, Luo Y.   +8 more
europepmc   +1 more source

Dyadic resistance during parent–adolescent interactions: A state space grid analysis before and after high school

Family Relations, Volume 75, Issue 2, Page 901-920, April 2026.
ABSTRACT Objective This study examined micro‐level resistance dynamics that occur during parent–adolescent interactions before and after the transition to high school. Background Although research on parent–adolescent disputes has emphasized global measures of frequency and intensity, less attention has been paid to the actions of resistance during ...
Daniel Ji, Frances Cabahug, Sheila K. Marshall   +2 more
wiley   +1 more source

Synergism of IP3R and Parkin mutants identifies mitochondrial stress as an early feature of Parkinson's disease. [PDF]

Dis Model Mech
Dileep M, Sharma A, Kasturacharya N, Nizami SK, Manjila S, Bhan A, Hasan G.   +6 more
europepmc   +1 more source

Parkin Pigs

, 2020
openaire   +2 more sources

‘What Do People With Long Covid Want From Healthcare Services?’ A Qualitative Exploration From Lived Experience

Health Expectations, Volume 29, Issue 2, April 2026.
ABSTRACT Background Long COVID (LC) is a chronic, multisystem condition affecting millions globally, with significant personal, social and economic consequences. Despite increasing recognition of its impact, healthcare services for LC remain inconsistent with patients frequently encountering fragmented services, scepticism and delays leading to patient‐
Clare Rayner, Nikki Smith, Ruairidh Milne, Ghazala Mir, Johannes de Kock, Nawar Diar Bakerly, The LOCOMOTION Consortium, Nawar Bakerly, Kumaran Balasundaram, Megan Ball, Mauricio Barahona, Alexander Casson, Jonathan Clarke, Karen Cook, Rowena Cooper, Vasa Curcin, Julie Darbyshire, Helen Davies, Helen Dawes, Simon de Lusignan, Brendan Delaney, Carlos Echevarria, Sarah Elkin, Ana Belen Espinosa Gonzalez, Rachael Evans, Sophie Evans, Zacchaeus Falope, Ben Glampson, Madeline Goodwin, Trish Greenhalgh, Darren C. Greenwood, Stephen Halpin, Juliet Harris, Will Hinton, Mike Horton, Samantha Jones, Joseph Kwon, Cassie Lee, Ashliegh Lovett, Mae Mansoubi, Victoria Masey, Harsha Master, Erik Mayer, Bernardo Meza‐Torres, Ruairidh Milne, Ghazala Mir, Jacqui Morris, Adam Mosley, Jordan Mullard, Daryl O'Connor, Rory O'Connor, Thomas Osborne, Amy Parkin, Stavros Petrou, Anton Pick, Denys Prociuk, Clare Rayner, Amy Rebane, Natalie Rogers, Janet Scott, Manoj Sivan, Nikki Smith, Adam Smith, Emma Tucker, Ian Tucker‐Bell, Paul Williams, Darren Winch, Conor Wood   +67 more
wiley   +1 more source

Therapeutic Promise of Mitophagy in Cancer: Advancing from Small-Molecule Regulation to Nanotechnology-Enhanced Targeting Therapy. [PDF]

Theranostics
Chen P, Liu G, Yin J, Sun L, Wang X, Wang B, Gong Q, Luo K.   +7 more
europepmc   +1 more source

Disulfide Crosslinking Induces Rapid Degradation of Arc/Arg3.1 via Hsp70‐Mediated Ubiquitin Ligase Pathway

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Heat shock induces Arc/Arg3.1 Cys34‐Cys159 disulfide crosslinking, promoting oligomerization and Hsp70‐CHIP‐dependent ubiquitination followed by proteasomal degradation during recovery. Disrupting disulfide formation (C159A) impairs CHIP‐mediated ubiquitination and stabilizes Arc/Arg3.1, whereas HSF1 loss limits inducible Hsp70 and leads to Arc ...
Dami So, In‐Kang Song, Yeon Jung Kim, Yeonjoo Lee, Yeon Seung Park, Hee‐Jung Kim, Kong‐Joo Lee, Eun Joo Song   +7 more
wiley   +1 more source

UBA5 deficiency disrupts mitochondrial autophagy via the PINK1-parkin pathway and impairs myoblast proliferation. [PDF]

Biol Res
Shi H, Cai Y, Liu Y.
europepmc   +1 more source

p62/SQSTM1 Condensation Modulates Mitochondrial Clustering to Participate in Mitochondrial Quality Control. [PDF]

Aging Cell
Sun S, Xin J, Zhang Y, Yang B, Su D, Ni R, Ma Q, Li N, Ma G, Peng Q, Chen S, Prehn JHM, Tam KY, Wang H, Ying Z.   +14 more
europepmc   +1 more source