Results 21 to 30 of about 226,162 (289)

Theatre Is a Valid Add-On Therapeutic Intervention for Emotional Rehabilitation of Parkinson’s Disease Patients

Parkinson's Disease, 2017
Conventional medical treatments of Parkinson’s disease (PD) are effective on motor disturbances but may have little impact on nonmotor symptoms, especially psychiatric ones.
Giovanni Mirabella, Paolo De Vita, Michele Fragola, Silvia Rampelli, Francesco Lena, Fulvia Dilettuso, Marta Iacopini, Raffaella d’Avella, Maria Concetta Borgese, Silvia Mazzotta, Deborah Lanni, Marco Grano, Sara Lubrani, Nicola Modugno   +13 more
doaj   +1 more source

Mitophagy in Diabetic Kidney Disease

Frontiers in Cell and Developmental Biology, 2021
Diabetic kidney disease (DKD) is the most common cause of end-stage kidney disease worldwide and is the main microvascular complication of diabetes.
Xiaofeng Zhang, Jing Feng, Xia Li, Dan Wu, Qian Wang, Shuyu Li, Changhua Shi   +6 more
doaj   +1 more source

PINK1 and Parkin Ameliorate the Loss of Motor Activity and Mitochondrial Dysfunction Induced by Peripheral Neuropathy-Associated HSPB8 Mutants in Drosophila Models

Biomedicines, 2023
Charcot–Marie–Tooth disease (CMT) is a group of inherited peripheral nerve disorders characterized by progressive muscle weakness and atrophy, sensory loss, foot deformities and steppage gait.
Kyong-hwa Kang, Ji Eun Han, Hyunjin Kim, Sohee Kim, Young Bin Hong, Jeanho Yun, Soo Hyun Nam, Byung-Ok Choi, Hyongjong Koh   +8 more
doaj   +1 more source

Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin [PDF]

, 2010
Loss of the E3 ubiquitin ligase Parkin causes early onset Parkinson's disease, a neurodegenerative disorder of unknown etiology. Parkin has been linked to multiple cellular processes including protein degradation, mitochondrial homeostasis, and autophagy;
A. J. Whitworth, Bueler, Chu, Clark, De Vos, E. Ziviani, Exner, Fallon, Gasser, Geisler, Kim, Koshiba, Liesa, Lim, Moore, Morais, Mortiboys, Narendra, Park, Park, Popp, R. N. Tao, Sandebring, Shimura, Soubannier, Steinbrink, Tatsuta, Twig, Whitworth   +28 more
core   +2 more sources

Parkin deficiency prevents chronic ethanol-induced hepatic lipid accumulation through β-catenin accumulation

Cell Communication and Signaling, 2019
Background Alcohol abuse and alcoholism lead to alcohol liver disease such as alcoholic fatty liver. Parkin is a component of the multiprotein E3 ubiquitin ligase complex and is associated with hepatic lipid accumulation.
Dong Hun Lee, Mi Hee Park, Chul Ju Hwang, Youngsoo Kim, Dae Yeon Hwang, Sang Bae Han, Jin Tae Hong   +6 more
doaj   +1 more source

Parkin beyond Parkinson’s Disease—A Functional Meaning of Parkin Downregulation in TDP-43 Proteinopathies

Cells, 2021
Parkin and PINK1 are key regulators of mitophagy, an autophagic pathway for selective elimination of dysfunctional mitochondria. To this date, parkin depletion has been associated with recessive early onset Parkinson’s disease (PD) caused by loss-of ...
Katarzyna Gaweda-Walerych, Emilia Jadwiga Sitek, Ewa Narożańska, Emanuele Buratti   +3 more
doaj   +1 more source

The PINK1/Parkin pathway: a mitochondrial quality control system? [PDF]

, 2009
Significant insight into the mechanisms that contribute to dopaminergic neurodegeneration in Parkinson disease has been gained from the analysis of genes linked to rare heritable forms of parkinsonism such as PINK1 and parkin, loss-of-function mutations ...
Pallanck, L.J., Whitworth, A.J.
core   +1 more source

Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function [PDF]

Human Molecular Genetics, 2005
Mutations in parkin are currently recognized as the most common cause of familial Parkinsonism. Emerging evidence also suggests that parkin expression variability may confer a risk for the development of the more common, sporadic form of Parkinson's disease (PD).
Wang, C., Chew, K.C.M., Tay, S.-P., Ho, M.W.L., Lim, K.-L., Lim, T.-M., Tsang, F., Soong, T.-W., Ko, H.S., Thomas, B., Dawson, V.L., Dawson, T.M., Troncoso, J., Pletnikova, O.   +13 more
openaire   +2 more sources

Resveratrol Treatment in Human Parkin-Mutant Fibroblasts Modulates cAMP and Calcium Homeostasis Regulating the Expression of Mitochondria-Associated Membranes Resident Proteins

Biomolecules, 2021
Parkin plays an important role in ensuring efficient mitochondrial function and calcium homeostasis. Parkin-mutant human fibroblasts, with defective oxidative phosphorylation activity, showed high basal cAMP level likely ascribed to increased activity ...
Anna Signorile, Anna Ferretta, Consiglia Pacelli, Nazzareno Capitanio, Paola Tanzarella, Maria Laura Matrella, Alessio Valletti, Domenico De Rasmo, Tiziana Cocco   +8 more
doaj   +1 more source

AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1 [PDF]

, 2014
Damaged mitochondria are eliminated by mitophagy, a selective form of autophagy whose dysfunction associates with neurodegenerative diseases. PINK1, PARKIN and p62/SQTMS1 have been shown to regulate mitophagy, leaving hitherto ill-defined the ...
A Follenzi, A Orvedahi, A Romagnoli, C Behrends, C Van Humbeeck, C Vives-Bauza, D Popovic, DP Narendra, EF Blommaart, F Cecconi, F Cecconi, F Nazio, F Nazio, F Strappazzon, F Strappazzon, G M Fimia, G Twig, GM Fimia, H Sandoval, J Jin, J Lippincott-Schwartz, JY Lee, K Okamoto, K Okatsu, M Campanella, M Campanella, M Corrado, M Cozzolino, M Kundu, M Piacentini, N Narendra, P Grumati, PA Andreux, PO Seglen, R Nardacci, RL Schweers, S Campello, S Geisler, S Hasson, S Pankiv, S Pistor, T Itoh, T Johansen, T Kanki, V Choubey, V Cianfanelli, Y Kabeya   +46 more
core   +4 more sources