Results 31 to 40 of about 226,162 (289)

Parkin regulation of CHOP modulates susceptibility to cardiac endoplasmic reticulum stress

Scientific Reports, 2017
The regulatory control of cardiac endoplasmic reticulum (ER) stress is incompletely characterized. As ER stress signaling upregulates the E3-ubiquitin ligase Parkin, we investigated the role of Parkin in cardiac ER stress. Parkin knockout mice exposed to
Kim Han, Shahin Hassanzadeh, Komudi Singh, Sara Menazza, Tiffany T. Nguyen, Mark V. Stevens, An Nguyen, Hong San, Stasia A. Anderson, Yongshun Lin, Jizhong Zou, Elizabeth Murphy, Michael N. Sack   +12 more
doaj   +1 more source

Olfaction in Parkin single and compound heterozygotes in a cohort of young onset Parkinson's disease patients [PDF]

, 2016
Background Parkin related Parkinson's disease (PD) is differentiated from idiopathic PD by absent or sparse Lewy bodies, and preserved olfaction. The significance of single Parkin mutations in the pathogenesis of PD is debated.
Bajaj, N. P., Barker, R. A., Ben-Shlomo, Y., Bresner, Catherine, Burn, D. J., Foltynie, T., Grosset, D. G., Grosset, K. A., Lawton, M. A., Malek, N., Morris, H. R., Smith, C. R., Swallow, D. M. A., Williams, Nigel, Wood, N. W.   +14 more
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Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering.

PLoS Genetics, 2014
The kinase PINK1 and the E3 ubiquitin (Ub) ligase Parkin participate in mitochondrial quality control. The phosphorylation of Ser65 in Parkin's ubiquitin-like (UBl) domain by PINK1 stimulates Parkin activation and translocation to damaged mitochondria ...
Kahori Shiba-Fukushima, Taku Arano, Gen Matsumoto, Tsuyoshi Inoshita, Shigeharu Yoshida, Yasushi Ishihama, Kwon-Yul Ryu, Nobuyuki Nukina, Nobutaka Hattori, Yuzuru Imai   +9 more
doaj   +1 more source

mutation dosage and the phenomenon of anticipation: a molecular genetic study of familial parkinsonism [PDF]

, 2005
Background: parkin mutations are a common cause of parkinsonism. Possessing two parkin mutations leads to early-onset parkinsonism, while having one mutation may predispose to lateonset disease.
Parvoneh Poorkaj, Lina Moses, Jennifer S Montimurro, John G Nutt, Gerard D Schellenberg, Haydeh Payami, T Kitada, T Kobayashi, CB Lucking, M Maruyama, C Klein, M Farrer, K Hedrich, A West, SA Oliveira, T Foroud, V Bonifati, H Payami, K Markopoulou, K Gwinn-Hardy, H Payami, DE Shan, AJ Hughes, DW Tsuang, CB Lucking, SJ Lincoln, RL Oliveri   +26 more
core   +2 more sources

Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation [PDF]

, 2015
This is the author accepted manuscript. The final version is available from EMBO Press via the DOI in this recordMutations in the mitochondrial protein kinase PINK1 are associated with autosomal recessive Parkinson disease (PD).
Alessi, Dario R, Gonzalez, Alba, Hope, Anthony G, Johnson, Clare, Kazlauskaite, Agne, Knebel, Axel, Kumar, Atul, Martínez-Torres, R Julio, Muqit, Miratul MK, Peggie, Mark, Peltier, Julien, Prescott, Alan R, Trost, Matthias, van Aalten, Daan Mf, Walden, Helen, Wilkie, Scott, Zhang, Jinwei   +16 more
core   +3 more sources

Inhibition of apoptotic Bax translocation to the mitochondria is a central function of parkin [PDF]

, 2014
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder, affecting 1–3% of the population over 65. Mutations in the ubiquitin E3 ligase parkin are the most common cause of autosomal recessive PD.
Charan, R A, Johnson, B N, LaVoie, M J, Nardozzi, J D, Zaganelli, S   +4 more
core   +1 more source

Risk of Parkinson disease in carriers of parkin mutations : estimation using the kin-cohort method [PDF]

, 2008
Objective: To estimate the risk of Parkinson disease (PD) in individuals with mutations in the Parkin gene. Design: We assessed point mutations and exon deletions and duplications in the Parkin gene in 247 probands with PD (age at onset 50 years) and ...
Andrews, Howard F., Clark, Lorraine N., Cote, Lucien J., Fahn, Stanley, Ford, Blair, Frucht, Steven, Harris, Juliette, Louis, Elan D., Marder, Karen, Mejia-Santana, Helen, Ottman, Ruth, Rabinowitz, Daniel, Wang, Yuanjia, Waters, Cheryl H.   +13 more
core   +2 more sources

Depletion of mitochondria in mammalian cells through enforced mitophagy [PDF]

, 2016
Mitochondria are not only the 'powerhouse' of the cell; they are also involved in a multitude of processes that include calcium storage, the cell cycle and cell death.
Correia-Melo, Clara, Ichim, Gabriel, Passos, João F., Tait, Stephen   +3 more
core   +1 more source

Glutamate excitotoxicity in neurons triggers mitochondrial and endoplasmic reticulum accumulation of Parkin, and, in the presence of N-acetyl cysteine, mitophagy

Neurobiology of Disease, 2015
Disruption of the dynamic properties of mitochondria (fission, fusion, transport, degradation, and biogenesis) has been implicated in the pathogenesis of neurodegenerative disorders, including Parkinson's disease (PD).
Victor S. Van Laar, Nikita Roy, Annie Liu, Swati Rajprohat, Beth Arnold, April A. Dukes, Cory D. Holbein, Sarah B. Berman   +7 more
doaj   +1 more source

Case-control study of the parkin gene in early-onset Parkinson disease [PDF]

, 2006
Background: Mutations in parkin are estimated to account for as much as 50% of familial Parkinson disease (PD) and 18% of sporadic PD. Single heterozygous mutations in parkin in both familial and sporadic cases may also increase susceptibility to PD.
Afridi, Shehla, Andrews, Howard F., Clark, Lorraine N., Cote, Lucien J., Fahn, Stanley, Ford, Blair, Frucht, Steven, Harris, Juliette, Karlins, Eric, Louis, Elan D., Marder, Karen, Mejia-Santana, Helen, Ottman, Ruth, Wang, Yuanjia, Waters, Cheryl H.   +14 more
core   +2 more sources