Results 51 to 60 of about 226,005 (247)

The complexity of dementia development and its comorbidities: The collaborative cross‐mouse population for multivarious tasks approach

Animal Models and Experimental Medicine, EarlyView.
The increasing prevalence of dementia and related neurodegenerative diseases—including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and amyotrophic lateral sclerosis—poses a growing public health challenge. These conditions have traditionally been studied as isolated central nervous system disorders, but emerging evidence points to ...
Osayd Zohud, Iqbal M. Lone, Kareem Midlej, Fuad A. Iraqi   +3 more
wiley   +1 more source

Association between Human Leukocyte Antigen Alleles and Neuropathological Outcomes in Lewy Body Disease

Annals of Neurology, EarlyView.
Objective Lewy body disease (LBD) is a complex neurodegenerative disorder characterized by the accumulation of misfolded α‐synuclein in the brain. Neuroinflammation has long been implicated in LBD pathogenesis, and recent genetic studies in Parkinson's disease (a clinical manifestation of LBD) have shown consistent association with the human leukocyte ...
Marios Gavrielatos, Michael G. Heckman, Alexandra I. Soto‐Beasley, Sophia G. Blumenfeld, Xu Hou, Shunsuke Koga, Melissa E. Murray, Koji Kasanuki, Daisuke Ono, Fabienne C. Fiesel, Ryan J. Uitti, Julie A. Fields, Hugo Botha, Vijay K. Ramanan, Kejal Kantarci, Val J. Lowe, Clifford R. Jack, Nilufer Ertekin‐Taner, J. Raphael Gibbs, Bryan J. Traynor, Clifton L. Dalgard, Rodolfo Savica, Jonathan Graff‐Radford, Ronald C. Petersen, R. Ross Reichard, Neill R. Graff‐Radford, Tanis J. Ferman, Bradley F. Boeve, Zbigniew K. Wszolek, Wolfdieter Springer, Ziv Gan‐Or, Emmanuel Mignot, Sonja W. Scholz, Dennis W. Dickson, Owen A. Ross   +34 more
wiley   +1 more source

Enhancing the Capacitance of Poly(Heptazine Imide) Electrodes in Aqueous Electrolytes via Hybrid Material Design

Batteries &Supercaps, EarlyView.
This work highlights the synthesis of a potassium poly(heptazine imide) K‐PHI@carbon hybrid material. The design of the hybrid improves the electrochemical properties of the semiconducting carbon nitride enabling the investigation of interaction between K‐PHI and different cations from the electrolyte.
Marius Hermesdorf, Ulrich Haagen, Ping Feng, Christof Neumann, Andrey Turchanin, Yan Lu, Desirée Leistenschneider   +6 more
wiley   +1 more source

Generation and physiological roles of linear ubiquitin chains [PDF]

, 2012
Ubiquitination now ranks with phosphorylation as one of the best-studied post-translational modifications of proteins with broad regulatory roles across all of biology.
A Ciechanover, A Degterev, A Hershko, A Hershko, A Hershko, A Varshavsky, B Eisenhaber, B Gerlach, C Tokunaga, CK Ea, CM Pickart, CY Ni, DM Wenzel, DW Abbott, EW Doss-Pepe, F Ikeda, F Ikeda, F Ikeda, F Tokunaga, F Tokunaga, F Van Herreweghe, H HogenEsch, H Walczak, H Zhou, Henning Walczak, I Marin, I Marin, Ivan Dikic, J Peng, JN Dynek, JW Harper, Kazuhiro Iwai, KL Lim, M Karin, O Micheau, P Cohen, P de Bie, P Xu, S Hatakeyama, S Rahighi, T Hunter, T Kirisako, TL Haas, V Nagy, VK Chaugule, Y Sato, Y Ye, YC Lo   +47 more
core   +4 more sources

‘A completely different space’: Teachers' perspectives on disadvantage, access to nature and outdoor learning

British Educational Research Journal, EarlyView.
Abstract This study examined teachers' perspectives on how children benefit from time in nature, how disadvantage shapes access and the role of schools in facilitating such access. Drawing on interviews conducted in 2022 with 25 UK primary school teachers who participated in Generation Wild, a nature connection programme for schools in economically ...
Nicola Parkin, Kersty Hobson, Wouter Poortinga, Mark Stead, Julia Newth, Jonathan Reeves, Merideth Gattis   +6 more
wiley   +1 more source

Parental involvement and engagement during COVID‐19 lockdowns: School staff and parents' reflections about children's learning at home

British Educational Research Journal, EarlyView.
Abstract Valuing parental engagement, as part of home–school collaboration, can benefit children's learning. This article focuses on parents and school‐based staff's (N = 120) experiences of children's learning occurring at home during the COVID‐19 lockdowns (2020–2021), both school‐mandated and other learning activities.
Ashley Brett, Bonny L. Hartley, Deborah Wallace, Adewale Magaji, Lorraine Smith, Rachel Wolfendale   +5 more
wiley   +1 more source

Mitochondrial dynamics–fusion, fission, movement, and mitophagy–in neurodegenerative diseases [PDF]

, 2009
Neurons are metabolically active cells with high energy demands at locations distant from the cell body. As a result, these cells are particularly dependent on mitochondrial function, as reflected by the observation that diseases of mitochondrial ...
Alexander, Baloyannis, Banchs, Bossy-Wetzel, Brockmann, Cassidy-Stone, Chang, Chen, Cho, Clark, D. C. Chan, de Brito, Delettre, Dodson, Exner, Fransson, Frezza, Gispert, H. Chen, Hollenbeck, Kim, Kim, Li, Liot, Lustbader, Macaskill, Meeusen, Milone, Mortiboys, Okamoto, Orr, Park, Parone, Popp, Reis, Suen, Ten Dijke, Trushina, Wang, Waterham, Wood-Kaczmar, Zuchner, Z  chner   +42 more
core   +3 more sources

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

BMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang, Yushan Zhang, Hang Li, Sirui Peng, Donghao Lyu, Chunxiao Zhou, Sheng Ding, Zujian Feng, Pingsheng Huang, Chuangnian Zhang, Hongjun Wang, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source

A strategic needs assessment for Nottinghamshire [PDF]

, 2013
Peter Murphy, Kirsten Greenhalgh and Craig Parkin from Nottingham Trent University, University of Nottingham and Nottinghamshire Fire and Rescue Service, report on their joint ...
Greenhalgh, K, Murphy, P, Parkin, C
core  

Therapeutic approaches to enhance PINK1/Parkin mediated mitophagy for the treatment of Parkinson's disease [PDF]

, 2019
The discovery of rare familial monogenic forms of early-onset Parkinson's disease has led to the identification of a mitochondrial quality control process as a key player in this disease.
Miller, Silke, Muqit, Miratul M. K.
core   +2 more sources