Results 161 to 170 of about 43,736 (227)

Aceruloplasminemia Presenting With Prominent Psychiatric Symptoms and Neurodegeneration: A Case Report

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Aceruloplasminemia (ACP) often presents with systemic, psychiatric, and neurological features. In this case, diabetes mellitus was diagnosed several years before psychiatric symptoms, which were then followed by neurological decline, which significantly delayed diagnosis.
Ali Almarzooqi, Abdulrahman Almarzooqi, Khalifa Juma, Hamda Kamalboor   +3 more
wiley   +1 more source

Intrastriatal gradient analyses of 18F-FDOPA PET scans for differentiation of Parkinsonian disorders. [PDF]

Neuroimage Clin, 2020
Stormezand GN, Chaves LT, Vállez García D, Doorduin J, De Jong BM, Leenders KL, Kremer BPH, Dierckx RAJO.   +7 more
europepmc   +1 more source

A Systematic Review on Disease‐Modifying Therapies in Parkinsonian Disorders

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 357-374, August 2026.
Parkinsonian disorders, including Parkinson's disease, Lewy body dementia, multiple system atrophy, and progressive supranuclear palsy, are progressive neurodegenerative conditions with no treatment options to slow disease progression. This systematic review provides an overview of evidence of disease‐modifying therapies that have been evaluated in ...
Pepijn P.N.M. Eijsvogel, Lars M.G. Smits, Philip H.C. Kremer, Geert Jan Groeneveld   +3 more
wiley   +1 more source

Discovery of a Potent and Selective MAO‐B Inhibitor From a Donepezil‐Linked Chalcone Library With Promising Antiparkinsonian Activity

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT A focused library of 19 donepezil‐linked chalcones (DLCs) was efficiently synthesised through microwave‐assisted Claisen‐Schmidt condensation and subsequently profiled for their inhibitory activities against cholinesterases (AChE and BuChE) as well as monoamine oxidases (MAO‐A and MAO‐B).
Azize Kirac‐Aydin, Bishnu Prasad Pandey, Satyajit Mohanty, Rupsa Mondal, Abanish Biswas, Ashok Kumar Pattnaik, Subodh Mondal, Vinay N. Basavanakatti, Nilüfer Bayrak, Venkatesan Jayaprakash, Hoon Kim, Amaç Fatih TuYuN   +11 more
wiley   +1 more source

Multimodel Diffusion MRI Signatures in Atypical Parkinsonian Disorders

Human Brain Mapping, Volume 47, Issue 11, 01 August 2026.
We implemented a diffusion MRI framework to analyze clinically compatible multishell data across 123 participants, including controls, Parkinson's disease (PD), corticobasal syndrome (CBS), and progressive supranuclear palsy Richardson's syndrome (PSP‐RS). Diffusion models included DTI, free‐water elimination (FWE), NODDI, and fixel‐based analysis (FBA)
Yuqi Tian, Farwa Ali, Mary M. Machulda, Val. J. Lowe, Keith A. Josephs, Jennifer L. Whitwell   +5 more
wiley   +1 more source

A New Statistical Framework for Corpus Callosum Sub-Region Characterization Based on LBP Texture in Patients With Parkinsonian Disorders: A Pilot Study. [PDF]

Front Neurosci, 2020
Bhattacharya D, Sinha N, Prasad S, Pal PK, Saini J, Mangalore S.   +5 more
europepmc   +1 more source

Mapping Neurodegenerative Changes in Clinically Uncertain Parkinsonian Syndrome Patients Using Fast MR Spin TomogrAphy in Time‐Domain (MR‐STAT) Relaxometry at 3T

Journal of Magnetic Resonance Imaging, Volume 64, Issue 2, Page 429-439, August 2026.
ABSTRACT Background MR Spin TomogrAphy in Time‐domain (MR‐STAT) enables accelerated multiparametric relaxometry (T1/T2). Previous relaxometry studies predominantly compared Parkinson's disease patients with healthy controls (HC). The potential of relaxometry to distinguish neurodegenerative from non‐neurodegenerative parkinsonism in clinically ...
Martin B. Schilder, Elon D. Wallert, Stefano Mandija, Oscar van der Heide, Hongyan Liu, Miha Fuderer, Edwin Versteeg, Jan Booij, Rob M. A. de Bie, Martijn Beudel, Henk W. Berendse, Tom van Mierlo, Jeroen Blankevoort, Cornelis A. T. van den Berg, Elsmarieke van de Giessen, Alessandro Sbrizzi   +15 more
wiley   +1 more source

Analysis of biomarkers in speculative CNS-enriched extracellular vesicles for parkinsonian disorders: a comprehensive systematic review and diagnostic meta-analysis. [PDF]

J Neurol
Taha HB, Bogoniewski A.
europepmc   +1 more source

Towards a Safe and Effective Lithium Therapeutic Range for Older Adults With Bipolar Disorder: An ISBD Task Force Systematic Review

Bipolar Disorders, Volume 28, Issue 5, August 2026.
ABSTRACT Objectives Lithium is recommended as the first‐line maintenance treatment for older adults with bipolar disorder (OABD). However, age‐related reduction in renal clearance, heightened sensitivity to adverse effects, and drug interactions increase the risk of toxicity and necessitate lower therapeutic serum levels in this population.
Paula V. Nunes, Andrew T. Olagunju, Debbie Zittema, Astha Dhyani, Lei Fu, Peijun Chen, Laura Montejo, Gabriel R. Fries, Lars V. Kessing, Eduard Vieta, Orestes V. Forlenza, Annemieke Dols, Hilary P. Blumberg, Lisa T. Eyler, Kenneth I. Shulman, on behalf of the International Society for Bipolar Disorders (ISBD) Older Adults with Bipolar Disorder (OABD) Lithium Workgroup Task Force   +15 more
wiley   +1 more source