Results 11 to 20 of about 55,623 (223)
Oncomodulin: The Enigmatic Parvalbumin Protein [PDF]
Frontiers in Molecular Neuroscience, 2019 EF-hand Ca2+-binding protein family members, α- and β-parvalbumins have been studied for decades. Yet, considerable information is lacking distinguishing functional differences between mammalian α-parvalbumin (PVALB) and oncomodulin (OCM), a branded β ...
Leslie K. Climer +3 more
semanticscholar +4 more sources
Parvalbumin interneuron vulnerability and brain disorders [PDF]
Neuropsychopharmacology, 2020 Parvalbumin-expressing interneurons (PV-INs) are highly vulnerable to stressors and have been implicated in many neuro-psychiatric diseases such as schizophrenia, Alzheimer's disease, autism spectrum disorder, and bipolar disorder. We examined the literature about the current knowledge of the physiological properties of PV-INs and gathered results from
Jacob B. Ruden, L. Dugan, C. Konradi
semanticscholar +3 more sources
Parvalbumin Interneuron Dendrites Enhance Gamma Oscillations [PDF]
SSRN Electronic Journal, 2021 Dendrites are important determinants of the input-output relationship of single neurons, but their role in network computations is not well understood. Here, we used a combination of dendritic patch-clamp recordings and in silico modeling to determine how dendrites of parvalbumin (PV)-expressing basket cells contribute to network oscillations in the ...
Birgit Kriener, Hua Hu, Koen Vervaeke
openaire +4 more sources
BACHD Mice Recapitulate the Striatal Parvalbuminergic Interneuron Loss Found in Huntington’s Disease
Frontiers in Neuroanatomy, 2021 Huntington’s disease (HD) is a dominantly inherited, adult-onset neurodegenerative disease characterized by motor, psychiatric, and cognitive abnormalities.
Vyshnavi Rallapalle +4 more
doaj +1 more source
Nature Communications, 2020 Social isolation during the juvenile critical window is detrimental to proper functioning of the prefrontal cortex (PFC) and establishment of appropriate adult social behaviors.
L. Bicks +15 more
semanticscholar +1 more source
Molecular Autism, 2022 Background Fragile X syndrome (FXS), the most common genetic cause of autism spectrum disorder and intellectual disability, is caused by the lack of fragile X mental retardation protein (FMRP) expression. FMRP is an mRNA binding protein with functions in
M. Kalinowska +6 more
semanticscholar +1 more source
Targeting parvalbumin promotes M2 macrophage polarization and energy expenditure in mice
Nature Communications, 2022 Exercise benefits M2 macrophage polarization, energy homeostasis and protects against obesity partially through exercise-induced circulating factors.
S. Lin +14 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2021 The neurobiological bases of mood instability are poorly understood. Neuronal network alterations and neurometabolic abnormalities have been implicated in the pathophysiology of mood and anxiety conditions associated with mood instability and hence are ...
Antonello Pinna +2 more
doaj +1 more source
Parvalbumin interneuron loss mediates repeated anesthesia-induced memory deficits in mice
The Journal of Clinical Investigation, 2023 Repeated or prolonged, but not short-term, general anesthesia during the early postnatal period causes long-lasting impairments in memory formation in various species.
Patricia Soriano Roque +24 more
doaj +1 more source
Myelination of parvalbumin interneurons shapes the function of cortical sensory inhibitory circuits
Nature Communications, 2020 Myelination of projection neurons by oligodendrocytes is key to optimize action potential conduction over long distances. However, a large fraction of myelin enwraps the axons of parvalbumin-positive fast-spiking interneurons (FSI), exclusively involved ...
N. Benamer +3 more
semanticscholar +1 more source