Results 41 to 50 of about 55,623 (223)

Social Stimulus Causes Aberrant Activation of the Medial Prefrontal Cortex in a Mouse Model With Autism-Like Behaviors

Frontiers in Synaptic Neuroscience, 2018
Autism spectrum disorder (ASD) is a highly prevalent and genetically heterogeneous brain disorder. Developing effective therapeutic interventions requires knowledge of the brain regions that malfunction and how they malfunction during ASD-relevant ...
Antonella Pirone, Jonathan M. Alexander, Jenny B. Koenig, Denise R. Cook-Snyder, Medha Palnati, Robert J. Wickham, Lillian Eden, Neha Shrestha, Leon Reijmers, Thomas Biederer, Klaus A. Miczek, Chris G. Dulla, Michele H. Jacob   +12 more
doaj   +1 more source

Oxidative stress-driven parvalbumin interneuron impairment as a common mechanism in models of schizophrenia

Molecular Psychiatry, 2017
Parvalbumin inhibitory interneurons (PVIs) are crucial for maintaining proper excitatory/inhibitory balance and high-frequency neuronal synchronization.
P. Steullet, Jan-Harry cabungcal, Joseph T. Coyle, Michael Didriksen, K. Gill, A. Grace, Takao K. Hensch, Takao K. Hensch, Anthony-Samuel LaMantia, L. Lindemann, T. Maynard, Urs Meyer, Hirofumi Morishita, Hirofumi Morishita, Hirofumi Morishita, Patricio O’Donnell, M. Puhl, M. Cuénod, Kim Q. Do   +18 more
semanticscholar   +1 more source

Eliminating the VGlut2-Dependent Glutamatergic Transmission of Parvalbumin-Expressing Neurons Leads to Deficits in Locomotion and Vocalization, Decreased Pain Sensitivity, and Increased Dominance

Frontiers in Behavioral Neuroscience, 2018
The calcium-binding protein parvalbumin (PV) is a recognized marker of short-axon GABA-ergic neurons in the cortex and the hippocampus. However in addition, PV is expressed by excitatory, glutamatergic neurons in various areas of the brain and spinal ...
Diana M. Roccaro-Waldmeyer, Franck Girard, Daniele Milani, Elisabetta Vannoni, Laurent Prétôt, David P. Wolfer, David P. Wolfer, David P. Wolfer, Marco R. Celio   +8 more
doaj   +1 more source

Unique contributions of parvalbumin and cholinergic interneurons in organizing striatal networks during movement

Nature Neuroscience, 2019
Striatal parvalbumin (PV) and cholinergic interneurons (CHIs) are poised to play major roles in behavior by coordinating the networks of medium spiny cells that relay motor output. However, the small numbers and scattered distribution of these cells have
H. Gritton, W. Howe, Michael F. Romano, A. Difeliceantonio, M. Kramer, Venkatesh Saligrama, Mark E. Bucklin, Dana Zemel, Xue Han   +8 more
semanticscholar   +1 more source

Gradient of Parvalbumin- and Somatostatin-Expressing Interneurons Across Cingulate Cortex Is Differentially Linked to Aggression and Sociability in BALB/cJ Mice

Frontiers in Psychiatry, 2019
Successfully navigating social interactions requires the precise and balanced integration of social and environmental cues. When such flexible information integration fails, maladaptive behavioral patterns arise, including excessive aggression, empathy ...
Sabrina van Heukelum, Floriana Mogavero, Melissa A.E. van de Wal, Femke E. Geers, Arthur S.C. França, Jan K. Buitelaar, Christian F. Beckmann, Jeffrey C. Glennon, Martha N. Havenith   +8 more
doaj   +1 more source

Pre-frontal parvalbumin interneurons in schizophrenia: a meta-analysis of post-mortem studies

Journal of neural transmission, 2019
Parvalbumin interneurons are fast-spiking GABAergic neurons that provide inhibitory control of cortical and subcortical circuits and are thought to be a key locus of the pathophysiology underlying schizophrenia.
S. Kaar, Ilinca Angelescu, T. Marques, O. Howes   +3 more
semanticscholar   +1 more source

Opposed hemodynamic responses following increased excitation and parvalbumin-based inhibition

Journal of Cerebral Blood Flow and Metabolism, 2020
Understanding cellular contributions to hemodynamic activity is essential for interpreting blood-based brain mapping signals. Optogenetic studies examining cell-specific influences on local hemodynamics have reported that excitatory activity results in ...
Joonhyuk Lee, Chloe L Stile, A. Bice, Z. P. Rosenthal, Ping Yan, A. Snyder, J. Lee, A. Bauer   +7 more
semanticscholar   +1 more source

Cell-type-specific modulation of neocortical activity by basal forebrain Input

Frontiers in Systems Neuroscience, 2013
Activation of the cholinergic neurons in the basal forebrain (BF) desynchronizes cortical activity and enhances sensory processing during arousal and attention.
Henry J Alitto, Henry J Alitto, Henry J Alitto, Yang eDan, Yang eDan, Yang eDan   +5 more
doaj   +1 more source

Parvalbumin interneuron in the ventral hippocampus functions as a discriminator in social memory

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Recent studies have identified the hippocampal projection neurons and related pathways that encode and keep social information about familiar conspecifics. On the other side of the coin, however, the neural mechanism for animals to determine
Xiaofei Deng, Lijia Gu, N. Sui, Jianyou Guo, Jing Liang   +4 more
semanticscholar   +1 more source

Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs–cAMP Signaling

Advanced Science, EarlyView.
Our study identifies MINAR1 as a novel regulator of cortical interneuron excitability and seizure susceptibility. MINAR1 is preferentially expressed in SST+ interneurons. Genetic ablation of MINAR1 leads to seizure hypersensitivity, reduced SST+ neuron excitability, and impaired Gαs–cAMP signaling, disrupting the E/I balance.
Wei‐Tang Liu, Zhi‐Bin Hu, Ling Hu, Yu‐Bing Wang, Qiong Zhang, Ning‐Ning Song, Xi‐Yue Liu, Jia‐Yin Chen, Hong‐Wen Zhu, Bing‐Yao Zhou, Yun‐Chao Tao, Li Zhao, Ze‐Xuan Li, Yi‐Wei Li, Jia‐Qi Chen, Si‐Xin Tu, Cong‐Cong Qi, Sai‐Dan Ding, Gang Peng, Lin Xu, Yu‐Qiang Ding   +20 more
wiley   +1 more source