Results 51 to 60 of about 55,623 (223)

Regional and sub-regional differences in hippocampal GABAergic neuronal vulnerability in the TgCRND8 mouse model of Alzheimer’s disease

Frontiers in Aging Neuroscience, 2015
Hippocampal network activity is predominantly coordinated by -amino-butyric acid (GABA)ergic neurons. We have previously hypothesized that the altered excitability of hippocampal neurons in Alzheimer's disease (AD), which manifests as increased in vivo ...
Marilia Silva Albequerque, Marilia Silva Albequerque, Marilia Silva Albequerque, Marilia Silva Albequerque, Ian eMahar, Ian eMahar, Ian eMahar, Maria Antonietta eDavoli, Maria Antonietta eDavoli, Jean-Guy eChabot, Jean-Guy eChabot, Naguib eMechawar, Naguib eMechawar, Naguib eMechawar, Naguib eMechawar, Rémi eQuirion, Rémi eQuirion, Slavica eKrantic, Slavica eKrantic, Slavica eKrantic, Slavica eKrantic   +20 more
doaj   +1 more source

Compensatory Interplay Between Clarin‐1 and Clarin‐2 Deafness‐Associated Proteins Governs Phenotypic Variability in Hearing

Advanced Science, EarlyView.
Functional compensation between clarin‐1 and clarin‐2 in cochlear hair cells. Hearing loss associated with CLRN1 mutations shows striking phenotypic variability; however, the underlying mechanisms remain poorly understood. This study reveals that clarin‐1 and clarin‐2 function cooperatively in cochlear hair cells to sustain mechanoelectrical ...
Maureen Wentling, Aïda Yakhlef Sanchez, Nicolas Thelen, Müge Senarisoy, Maria Hogg, Steven Condamine, Andrea Lelli, Emilia Wysocka, Pranav Patni, Sandrine Vitry, Kerem Yasin Yildizhan, Sébastien Le Gal, Sylvie Nouaille, Michael R. Bowl, Marc Thiry, Didier Dulon, Sedigheh Delmaghani, Aziz El‐Amraoui   +17 more
wiley   +1 more source

Molecular Specialization of GABAergic Synapses on the Soma and Axon in Cortical and Hippocampal Circuit Function and Dysfunction

Frontiers in Molecular Neuroscience, 2019
The diversity of inhibitory interneurons allows for the coordination and modulation of excitatory principal cell firing. Interneurons that release GABA (γ-aminobutyric acid) onto the soma and axon exert powerful control by virtue of proximity to the site
April Contreras, Dustin J. Hines, Rochelle M. Hines   +2 more
doaj   +1 more source

IHC_cFOS+Parvalbumin v1

, 2023
Immunohistochemistry protocol for c-FOS and Parvalbumin co-staining of mouse brain tissue slices (30 microns thick).
openaire   +1 more source

Deep Brain Stimulation Induces Antidepressant Effects by Restoring High‐Fidelity Communication in the BNST‐NAc Circuit

Advanced Science, EarlyView.
This cross‐species study reveals that pathological hyperactivity of BNST neurons in depressive states disrupts inhibitory period and isolated spikes in the BNST‐NAc circuit. DBS achieves its antidepressant effects by precisely restoring network inhibitory periods and high‐fidelity signal transmission.
Xin Lv, Yu Cao, Yuhan Wang, Yunhao Wu, Yingying Zhang, Kuanghao Ye, Xian Qiu, Qingfang Sun, Liuguan Bian, Halimureti Paerhati, Valerie Voon, Shikun Zhan, Bomin Sun   +12 more
wiley   +1 more source

High-pressure processing (HPP) impacts on indian mackerel meat: insights into quality attributes, β-parvalbumin antigenicity, and proteomic changes

Applied Food Research
High-pressure processing (HPP) is a non-thermal method that uses high hydrostatic pressure on food products to improve quality and shelf life. However, it can cause structural changes in proteins that alter food characteristics.
Marcella Meia Gary Enchangan, Muhammad Syamil Seman, Jameel R. Al-Obaidi, Atiqah Farah Zakaria, Ahmad Faizal Abdull Razis, Nazamid Saari, Hanis Hazeera Harith, Nuzul Noorahya Jambari   +7 more
doaj   +1 more source

Parvalbumin-Deficiency Accelerates the Age-Dependent ROS Production in Pvalb Neurons in vivo: Link to Neurodevelopmental Disorders

Frontiers in Cellular Neuroscience, 2020
In neurodevelopmental disorders (NDDs) including autism spectrum disorder (ASD) and schizophrenia, impairment/malfunctioning of a subpopulation of interneurons expressing the calcium-binding protein parvalbumin (PV) –here termed Pvalb neurons– has ...
Lucia Janickova, Beat Schwaller
doaj   +1 more source

Parvalbumin-expressing interneurons coordinate hippocampal network dynamics required for memory consolidation

Nature Communications, 2017
Activity in hippocampal area CA1 is essential for consolidating episodic memories, but it is unclear how CA1 activity patterns drive memory formation.
Nicolette Ognjanovski, Samantha Schaeffer, Jiaxing Wu, S. Mofakham, D. Maruyama, M. Zochowski, S. Aton   +6 more
semanticscholar   +1 more source

Parvalbumin neurons in the forebrain as revealed by parvalbumin-Cre transgenic mice

Neuroscience Research, 2009
Neurons expressing the calcium-binding protein parvalbumin (PV) constitute an abundant subpopulation of GABAergic neurons in the cerebral cortex. However, PV is not unique to the GABAergic neurons of the forebrain, but is also expressed in a small number of pyramidal neurons and in a large number of thalamic neurons.
Chiyoko, Tanahira, Shigeyoshi, Higo, Keisuke, Watanabe, Ryohei, Tomioka, Satoe, Ebihara, Takeshi, Kaneko, Nobuaki, Tamamaki   +6 more
openaire   +2 more sources

Nanomaterial‐Mediated Near‐Infrared Photothermal Neuromodulation for Neurologic Disorders

Advanced NanoBiomed Research, EarlyView.
This review summarizes how near‐infrared light activates photothermal nanomaterials to enable noninvasive neuromodulation with high spatiotemporal precision. It elucidates the underlying mechanisms, explores targeted therapeutic applications for neurological disorders, discusses integration with optogenetics and biosensors, and addresses future ...
Ting‐Ting Zeng, Yu‐Ge Wang, Ya‐Bing Zhang, Yuan‐Xin Bai, Si‐Tong Lin, Ting‐Ting Zhu, Yan‐Bo Zhou, Wei‐Tong Pan, Pan‐Miao Liu, Jian‐Jun Yang   +9 more
wiley   +1 more source