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Patch-clamp and multi-electrode array electrophysiological analysis in acute mouse brain slices
STAR Protocols, 2021 Summary: Patch-clamp and multi-electrode array electrophysiology techniques are used to measure dynamic functional properties of neurons. Whole-cell and cell-attached patch-clamp recordings in brain slices can be performed in voltage-clamp and current ...
Kevin M. Manz +3 more
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In Vivo Whole-Cell Patch-Clamp Methods: Recent Technical Progress and Future Perspectives
Sensors, 2021 Brain functions are fundamental for the survival of organisms, and they are supported by neural circuits consisting of a variety of neurons. To investigate the function of neurons at the single-cell level, researchers often use whole-cell patch-clamp ...
Asako Noguchi +2 more
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Frontiers in Aging Neuroscience, 2021 A patch-clamp recording in slices generated from the brain or the spinal cord has facilitated the exploration of neuronal circuits and the molecular mechanisms underlying neurological disorders.
Yang Li +5 more
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Whole-cell and Perforated Patch-clamp Recordings from Acutely-isolated Murine Sino-atrial Node Cells
Bio-Protocol, 2020 Cardiac pacemaker cells of the sino-atrial node are responsible for the initiation of the heart beat and express an array of ion channels. The patch-clamp technique is the gold standard method for investigating the function of ion channels expressed in ...
Qadeer Aziz +2 more
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Nanotechnology: new opportunities for the development of patch‐clamps
Journal of Nanobiotechnology, 2021 The patch-clamp technique is one of the best approaches to investigate neural excitability. Impressive improvements towards the automation of the patch-clamp technique have been made, but obvious limitations and hurdles still exist, such as ...
Jia Gao +4 more
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Frontiers in Pharmacology, 2021 The transient receptor potential vanilloid type 1 (TRPV1) channel is a non-selective cation channel expressed with transient receptor potential ankyrin type 1 (TRPA1) in small and medial size neurons of the dorsal root ganglions and trigeminal ganglions.
Kaori Takahashi +6 more
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Equilibrium Research, 2008 The patch clamp technique enables the analyses of various ion channel characteristics of individual cells in vitro. The most important difference from previous techniques is that the microelectrode (pipette) is firmly attached to the cell surface instead of being inserted into the cells, and the so-called "giga-ohm seal" is attained. Usually, the whole
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Stem Cell Research, 2023 Genetically encoded voltage indicators (GEVIs) allow for monitoring membrane potential changes in neurons and cardiomyocytes (CMs) as an alternative to patch-clamp techniques.
Rajesh Vivekanandan +8 more
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Functional dissection of synaptic circuits: in vivo patch-clamp recording in neuroscience
Frontiers in Neural Circuits, 2015 Neuronal activity is dominated by synaptic inputs from excitatory or inhibitory neural circuits. With the development of in vivo patch-clamp recording, especially in vivo voltage-clamp recording, researchers can not only directly measure neuronal ...
Can eTao +3 more
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Alpha-Adrenoceptor Antagonists Improve Memory by Activating -methyl-D-Aspartate-Induced Ion Currents in the Rat Hippocampus [PDF]
International Neurourology Journal, 2015 Purpose: Alpha1 (α1)-adrenoceptor antagonists are widely used to treat lower urinary tract symptoms. These drugs not only act on peripheral tissues, but also cross the blood-brain barrier and affect the central nervous system.
Chang Hee Kim +9 more
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