Results 11 to 20 of about 38,690 (242)
Heliyon, 2023 Pharmacological studies aimed at the development of newly synthesized drugs directed against ion channels (as well as genetic studies of ion channel mutations) involve the development and use of transfected cells.
Alberto Montalbano +4 more
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Electrophysiological evaluation of the effect of peptide toxins on voltage-gated ion channels: a scoping review on theoretical and methodological aspects with focus on the Central and South American experience [PDF]
Journal of Venomous Animals and Toxins including Tropical DiseasesThe effect of peptide toxins on voltage-gated ion channels can be reliably assessed using electrophysiological assays, such as the patch-clamp technique.
Jessica Rojas-Palomino +5 more
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Frontiers in Cellular Neuroscience, 2014 Understanding non-stationary neuronal activity as seen in vivo requires estimation of both excitatory and inhibitory synaptic conductances from a single trial of recording.
Anton eChizhov +5 more
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Q&A: using Patch-seq to profile single cells
BMC Biology, 2017 Individual neurons vary widely in terms of their gene expression, morphology, and electrophysiological properties. While many techniques exist to study single-cell variability along one or two of these dimensions, very few techniques can assess all three
Cathryn R. Cadwell +3 more
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An efficient and scalable data analysis solution for automated electrophysiology platforms
SLAS Discovery, 2022 Ion channels are drug targets for neurologic, cardiac, and immunologic diseases. Many disease-associated mutations and drugs modulate voltage-gated ion channel activation and inactivation, suggesting that characterizing state-dependent effects of test ...
Tianbo Li +6 more
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PFI-3 induces vasorelaxation with potency to reduce extracellular calcium influx in rat mesenteric artery [PDF]
PeerJ, 2023 Background PFI-3 is a small-molecule inhibitor that targets the bromodomains (BRDs) of Brahma-related gene 1 (BRG1). This monomeric compound, which has high selectivity and potent cellular effects, has recently been developed.
Jing Li +13 more
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Frontiers in Pharmacology, 2011 All excitable cell functions rely upon ion channels that are embedded in their plasma membrane. Perturbations of ion channel structure or function result in pathologies ranging from cardiac dysfunction to neurodegenerative disorders.
Christophe ePy +11 more
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Dendritic patch-clamp recordings from cerebellar granule cells demonstrate electrotonic compactness
Frontiers in Cellular Neuroscience, 2015 Cerebellar granule cells (GC), the smallest neurons in the brain, have on average four short dendrites that receive high-frequency mossy fiber inputs conveying sensory information.
Igor eDelvendahl +2 more
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Methadone interrupts neural growth and function in human cortical organoids
Stem Cell Research, 2020 Prenatal opioids exposure can lead to both neonatal abstinence syndrome in newborns and neurological deficits later in life. Although opioids have been well studied in general, the cellular and molecular mechanisms by which opioids affect human fetal ...
Hang Yao +7 more
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Optical electrophysiology for probing function and pharmacology of voltage-gated ion channels
eLife, 2016 Voltage-gated ion channels mediate electrical dynamics in excitable tissues and are an important class of drug targets. Channels can gate in sub-millisecond timescales, show complex manifolds of conformational states, and often show state-dependent ...
Hongkang Zhang +2 more
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